Director, Benign Hematology, Professor of Molecular Medicine, Cleveland Clinic
Hematology
Dr. Keith R. McCrae, MD
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Keith McCrae works in the field of Hematology. He attended Duke University School of Medicine. Duke University School of Medicine is one of the top medical schools in the US. Duke University School of Medicine is ranked 8 in research and 29 in primary care medicine He received awards:"CMS Meaningful Use Stage 1 Certification" and "Elected Member". Dr. Keith R. McCrae has written publications. He has 90 publications published with PubMed. The lastest publication is: 'The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast cells.' Dr. Keith R. McCrae accepts all Medicare patients.
Publications
- Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice.
- Circulating microparticles in patients with Antiphospholipid antibodies: Characterization and associations.
- High-Relaxivity Superparamagnetic Iron Oxide Nanoworms With Decreased Immune Recognition and Long-Circulating Properties.
- Recent advances in the Antiphospholipid antibody syndrome.
- Rituximab for treatment of inhibitors in haemophilia A. A Phase II Study.
- The least of 3 evils: Exposure to red blood cell transfusion, Anemia, or both?
- Anti-β2GPI antibodies stimulate endothelial Cell microparticle release via a non-muscle myosin II motor protein-dependent pathway.
- Management and outcomes for patients With TTP: Analysis of 100 cases at a single institution.
- Approaches to synthetic Platelet analogs.
- Chimeric Glutathione S-Transferases Containing Inserts of Kininogen Peptides: POTENTIAL NOVEL PROTEIN THERAPEUTICS.
- A novel pathway for human endothelial cell activation by Antiphospholipid/anti-?2 glycoprotein I antibodies.
- Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is Associated with reduction in microparticles.
- RhIG for the treatment of Immune thrombocytopenia: consensus and controversy.
- Endothelial cell activation by Antiphospholipid antibodies is modulated by Kruppel-like transcription factors.
- Sutton's law and anti-β₂GPI antibodies.
- Blind men and the APS.
- Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis.
- Dose of prophylactic Platelet transfusions and prevention of hemorrhage.
- Impaired fibrinolysis in the Antiphospholipid syndrome.
- Immune thrombocytopenia in Pregnancy.
- beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activation.
- Noonan Syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
- SOS! Defibrotide to the rescue.
- Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to Thrombosis in mice.
- Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays Thrombosis.
- Human tropomyosin isoforms in the regulation of cytoskeleton functions.
- Complications from vascular disrupting agents and angiogenesis inhibitors: aberrant control of hemostasis and Thrombosis.
- Immune thrombocytopenic purpura in Pregnancy.
- A closer look at intravascular hemolysis (IVH) following intravenous anti-D for Immune thrombocytopenic purpura (ITP).
- Endothelial-Cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species.
- Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-Associated herpesvirus latency in vitro and in vivo.
- Annexin A2 mediates endothelial cell activation by Antiphospholipid/anti-beta2 glycoprotein I antibodies.
- Splenectomy in Immune thrombocytopenic purpura: recent controversies and long-term outcomes.
- Human monoclonal Antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and fu...
- Successful management of life-threatening hemorrhage in a patient With synchronous lupus anticoagulant and factor VIII inhibitor.
- The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial Cell tropomyosin.
- Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain.
- A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intraVenous schedule in patients ...
- Synthesis and expression of C1 inhibitor by human umbilical Vein endothelial cells.
- Immune thrombocytopenia: no longer 'idiopathic'.
- Inflammatory Breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin.
- Acute profound thrombocytopenia with second exposure to eptifibatide Associated with a strong antibody reaction.
- Von Willebrand Disease: screening, diagnosis, and management.
- Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.
- A vasculature-targeting regimen of preoperative docetaxel with or without bevacizumab for locally advanced Breast cancer: impact on angiogenic biomarkers.
- Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance.
- Promise of new vascular-disrupting agents balanced With cardiac toxicity: is it time for oncologists to get to know their cardiologists?
- A randomized, controlled Phase III trial of therapeutic plasma exchange With fresh-frozen plasma (FFP) prepared With amotosalen and ultraviolet A light compared to unt...
- Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416.
- ExtraCellular tropomyosin: a novel common pathway target for anti-angiogenic therapy.
- A phase IB clinical and pharmacokinetic study of the angiogenesis inhibitor SU5416 and paclitaxel in recurrent or metastatic carcinoma of the head and neck.
- Arterial Thrombosis in a gynecologic oncology patient: evaluation and management.
- Inhibition of angiogenesis by two-chain high molecular weight kininogen (HKa) and kininogen-derived polypeptides.
- Platelets: an update on diagnosis and management of thrombocytopenic Disorders.
- Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity Within domain 5.
- Regulation of the ligand binding activity of the human very low density lipoprotein receptor by protein kinase C-dependent phosphorylation.
- High affinity binding of beta 2-glycoprotein I to human endothelial Cells is mediated by annexin II.
- Persistant pre-eclampsia post partum with elevated liver enzymes and hemolytic uremic Syndrome.
- The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor regulates Cell surface plasminogen activator activity on human trophoblast Cells.
- SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-...
- Endothelial cells in physiology and in the pathophysiology of vascular Disorders.
- Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway.
- Binding of high molecular weight kininogen to human endothelial cells is mediated via a site Within domains 2 and 3 of the urokinase receptor.
- Physical and biological significance of peptide sequences mediating the interaction between high molecular weight kininogen and plasma prekallikrein.
- High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial Cell surfaces and subsequent urokinase-dependent plasmin formation.
- Antiphospholipid antibody associated thrombosis: a consensus for treatment?
- Thrombotic microangiopathy during Pregnancy.
- Altered expression of gelatinase and surface-Associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients.
- Posttransfusion Purpura: two unusual cases and a literature review.
- Interaction of single-chain urokinase With its receptor induces the appearance and disappearance of binding epitopes Within the resultant complex for other cell surfac...
- Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry.
- The Antiphospholipid-protein syndrome.
- Plasma concentration of endothelin-1 in women with cocaine-associated Pregnancy complications.
- Expression of urokinase receptors by human trophoblast. A histochemical and ultrastructural analysis.
- Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental l...
- Detection of antitrophoblast antibodies in the sera of patients With anticardiolipin antibodies and fetal loss.
- The very low density lipoprotein receptor mediates the Cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes.
- Tissue-type plasminogen activator binding to human endothelial Cells. Evidence for two distinct binding sites.
- Platelet activation induces increased Fc gamma receptor expression.
- Detection of endothelial cell-reactive immunoglobulin in patients With anti-phospholipid antibodies.
- Pregnancy-associated thrombocytopenia: pathogenesis and management.
- Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation.
- Characterization of urokinase receptor expression by human placental trophoblasts.
- Inhibition of cholesterol biosynthesis in Chinese hamster ovary Cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.
- Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5.
- Thrombocytopenia in Pregnancy: differential diagnosis, pathogenesis, and management.
- Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through Cell surface tropomyosin on endothelial Cells.
- Annexin A2: biology and relevance to the Antiphospholipid syndrome.
- The plasma kallikrein-kinin system: its evolution from contact activation.
Schools
Duke University School Of Medicine
Duke University Med Center
Hospital Of The University Of Pennsylvania
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Breast Cancer
- Coagulation Defects in Pregnancy and Postpartum
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Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
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University of Pennsylvania Health System -
Duke University Hospital -
Duke University School of Medicine
Hospital
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Cleveland Clinic
Drug Facts
| NPI NUMBER | 1356367973 | |
| NPPES Provider LastName | MCCRAE | |
| NPPES Provider FirstName | KEITH | |
| NPPES Provider ZIPCode | 441061716 | |
| NPPES Provider State | OH | |
| Specialty Description | Hematology/Oncology | |
| Total Claim Count | 88.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1356367973 |
| Last Name Of The Provider | MCCRAE |
| First Name Of The Provider | KEITH |
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