Professor, Medicine, Perelman School of Medicine
Cardiology
Dr. Kenneth B. Margulies, MD
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Kenneth Margulies works in the field of Cardiology. He went to Jefferson Medical College. He received 13 awards: "Regional Top Doctor", "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Outstanding Educator Award", "Clinician Scientist Development Award", "Donald C. Balfour Award", "Cardiovascular Trainee Research Award", "Midwest Trainee Award", "Travel Award", "Honorable Mention", "Hobart A. Hare Honor Medical Society", "Honors Certificate" and "Fellow (FACC)". Kenneth B. Margulies, MD is also a published MD. He has 100 publication published. The most recent publication is: Regression of cellular hypertrophy after left ventricular assist device support. He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.
- Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35.
- Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart.
- Identifying Biomarker Patterns and Predictors of Inflammation and Myocardial Stress.
- The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction.
- RNA-Seq identifies novel myocardial gene expression signatures of Heart failure.
- GLP-1 Agonist Therapy for Advanced Heart Failure With Reduced Ejection Fraction: Design and Rationale for the Functional Impact of GLP-1 for Heart Failure Treatment St...
- Genetic association study of QT interval highlights role for calcium signaling pathways in Myocardial repolarization.
- A Bioengineered Hydrogel System Enables Targeted and Sustained IntraMyocardial Delivery of Neuregulin, Activating the Cardiomyocyte Cell Cycle and Enhancing Ventricula...
- Emerging Tools for Computer-Aided Diagnosis and Prognostication.
- Dynamic left ventricular assist device inflow obstruction.
- Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction: The ROSE Acute Heart Failure Randomized Trial.
- Gene Expression and Genetic Variation in Human Atria.
- BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure.
- Divergent mitochondrial biogenesis responses in human Cardiomyopathy.
- Management of ventricular Arrhythmias in patients with ventricular assist devices.
- Hybrid mathematical model of cardiomyocyte turnover in the adult human Heart.
- Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium.
- Differential Expression of PDE5 in Failing and Nonfailing Human Myocardium.
- Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human Hearts: GC-A is inactive in the failed cardiomyocyte.
- A MICROFABRICATED PLATFORM TO MEASURE AND MANIPULATE THE MECHANICS OF ENGINEERED CARDIAC MICROTISSUES.
- Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused Heart.
- Adaptations to pulsatile versus nonpulsatile ventricular assist device support.
- S100A1: Another Step Toward Therapeutic Development for Heart Failure.
- Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in Heart failure.
- Functional genomics applied to cardiovascular medicine.
- Resistance training improves vasoreactivity in end-stage Heart failure patients on inotropic support.
- Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents.
- Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils.
- Decreased cardiac functional reserve in Heart failure with preserved systolic function.
- Ventilatory inefficiency reflects right ventricular dysfunction in systolic Heart failure.
- Biomarkers of Myocardial Stress and Systemic Inflammation in Patients Who Engage in Heart Failure Self-care Management.
- Differential Regulation of PDE5 Expression in Left and Right Ventricles of Feline Hypertrophy Models.
- Myocardial Reverse Remodeling.
- Strong synaptic transmission impact by copy number variations in schizophrenia.
- Current status of stem cell therapy in Heart failure.
- Klf15 deficiency is a molecular link between heart failure and aortic Aneurysm formation.
- MicroRNAs as novel Myocardial biomarkers.
- Melanocyte-like cells in the Heart and pulmonary veins contribute to atrial arrhythmia triggers.
- Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human Heart failure.
- Genomics, transcriptional profiling, and Heart failure.
- Reciprocal regulation of myocardial microRNAs and messenger RNA in human Cardiomyopathy and reversal of the microRNA signature by biomechanical support.
- Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.
- Sex and age dimorphism of myocardial gene expression in nonischemic human Heart failure.
- Apoptosis signal-regulating kinase 1 attenuates Atrial natriuretic peptide secretion.
- Increased cardiac myocyte progenitors in failing human Hearts.
- Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.
- The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity.
- Sex-based differences in Myocardial contractile reserve.
- Cardiac dysfunction and Heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.
- Transcriptional genomics associates FOX transcription factors with human Heart failure.
- Visualizing the basis for paracrine natriuretic peptide signaling in human Heart.
- Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium.
- Effect of Acute unloading via head-up tilt on QTc prolongation in patients with ischemic or non-ischemic cardiomyopathy.
- Regionally heterogeneous tissue mechanics in cardiac amyloidosis.
- Impaired vasoreactivity in end-stage heart failure patients on intraVenous inotropic support.
- Subvalvular alterations promote increased mitral Valve regurgitation in progressive dilated cardiomyopathy.
- Prolonged repolarization after ventricular assist device support is associated with arrhythmias in humans with congestive Heart failure.
- Mixed messages: transcription patterns in failing and recovering human myocardium.
- Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,...
- Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human Heart.
- Mechanical approaches to alter remodeling.
- Blocking stretch-induced Myocardial remodeling.
- Early and late results of left ventricular reshaping by passive cardiac-support device in canine Heart failure.
- CardioClasp changes left ventricular shape Acutely in enlarged canine heart.
- Unloading-induced remodeling in the normal and hypertrophic left ventricle.
- Cellular basis of abnormal calcium transients of failing human ventricular myocytes.
- Is depressed myocyte contractility centrally involved in Heart failure?
- Gender differences in post-infarction hypertrophy in end-stage failing Hearts.
- Reversal mechanisms of left ventricular remodeling: lessons from left ventricular assist device experiments.
- Calcium influx via I(NCX) is favored in failing human ventricular myocytes.
- Ca influx via the Na/Ca exchanger maintains sarcoplasmic reticulum Ca content in failing human myocytes.
- Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange.
- L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices.
- Contractile protein abnormalities in failing Hearts.
- Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes.
- Myocyte recovery after mechanical circulatory support in humans with end-stage Heart failure.
- Regression of cellular hypertrophy after left ventricular assist device support.
- The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes.
- Physiological significance of early deceleration time prolongation in asymptomatic elderly subjects.
- Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes.
- Ventricular unloading and myocyte recovery: insight gained into the pathophysiology of congestive Heart failure.
- Preserved contractile function despite atrophic remodeling in unloaded rat Hearts.
- Patients with end-stage congestive Heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance.
- Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac Failure.
- Differential regulation of mitogen-activated protein kinases in the failing human Heart in response to mechanical unloading.
- Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine Hearts.
- Claudin-5 levels are reduced in human end-stage Cardiomyopathy.
- Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
- Restoration of beta1 adrenergic receptor density.
- Homeodomain only protein x is down-regulated in human Heart failure.
- Reciprocal regulation of metabolic and signaling pathways.
- Loss of beta1D-integrin function in human ischemic Cardiomyopathy.
- Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group.
- Impaired contractile reserve in severe mitral Valve regurgitation with a preserved ejection fraction.
- Periostin and periostin-like factor in the human Heart: possible therapeutic targets.
- Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile Failure in human myocardium.
- Elevated myocardial and lymphocyte GRK2 expression and activity in human Heart failure.
- Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes.
Schools
Jefferson Medical College Of Thomas Jefferson University Thomas Jefferson University
Mayo Clinic Rochester
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Automatic Implantable Cardioverter Defibrillator (ICD) Implantation
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
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Conditions Treated
- Acute Venous Embolism Thrombosis
- Aneurysm and Dissection of Heart
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
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Doctors Specialties
- Cardiology
Accepted Insurances
- Aetna HMO
- American Republic
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Bakery & Confectionary Union Plan
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Coventry Health America PPO
- Coventry Health Care of Delaware PPO
- Emblem Health
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- HealthPartners
- Community Blue PPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Kaiser Permanente
- Keystone Health Plan East HMO
- Medicaid
- Medicare MCR
- Meritain Health
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- Regional Top Doctor
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Outstanding Educator Award
- Clinician Scientist Development Award
- Donald C. Balfour Award
- Cardiovascular Trainee Research Award
- Midwest Trainee Award
- Travel Award
- Honorable Mention
- Hobart A. Hare Honor Medical Society
- Honors Certificate
- Fellow (FACC)
Education
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Mayo School of Graduate Medical Education -
Jefferson Medical College
Hospital
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Hospital of the University of Pennsylvania
Drug Facts
| NPI NUMBER | 1720015647 | |
| NPPES Provider LastName | MARGULIES | |
| NPPES Provider FirstName | KENNETH | |
| NPPES Provider ZIPCode | 191045127 | |
| NPPES Provider State | PA | |
| Specialty Description | Cardiology | |
| Total Claim Count | 667.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1720015647 |
| Last Name Of The Provider | MARGULIES |
| First Name Of The Provider | KENNETH |
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