Reuler-Lewin Family Professor and chair neurology
Neurology
Dr. Kenneth L. Tyler, MD
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Kenneth Tyler works in the field of Neurology. He researched medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical college. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care He received 9 awards: "Regional Top Doctor", "Elected Fellow", "40th Aird Professor", "Elected Member", "Chair", "Lippard Lecturer", "Landau Lecturer", "Associate Editor" and "Editorial Board". Dr. Kenneth L. Tyler is also published. He has 100 publications published. The lastest publication: "Anti-diarrhoeal effects of seirogan in the rat small intestine and colon examined in vitro.'
Publications
- Four emerging arboviral Diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus Diseases.
- Assessment of colon and bladder crosstalk in an experimental colitis model using contrast-enhanced magnetic resonance imaging.
- 2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis...
- Mechanisms of Visceral Organ Crosstalk: Importance of Alterations in Permeability in Rodent Models.
- The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis.
- Fingolimod and Risk of Varicella-Zoster Virus Infection: Back to the Future With an Old Infection and a New Drug.
- Activation of Intrinsic Immune Responses and Microglial Phagocytosis in an Ex Vivo Spinal Cord Slice Culture Model of West Nile Virus Infection.
- Current developments in understanding of West Nile virus central nervous system Disease.
- Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a Peripheral immune response.
- Elevated CSF Cytokines in the Jarisch-Herxheimer Reaction of General Paresis.
- PML therapy: "It's Déjàvu all over again"
- A 20-year-old woman with Headache and transient numbness.
- Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis.
- West Nile and St. Louis encephalitis viruses.
- Magnetic resonance imaging in phenylketonuria: reversal of Cerebral white matter change.
- Magnetic resonance imaging of the brain in phenylketonuria.
- A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats.
- William Richard Gowers (1845-1915).
- A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia.
- Anti-diarrhoeal effects of seirogan in the rat small intestine and colon examined in vitro.
- Viruses, the immune system and central nervous system Diseases.
- Creutzfeldt-Jakob Disease and bovine spongiform encephalopathy: any connection?
- Lawrence Chester McHenry, Jr, MD (1929-1985).
- Fragments of neurological history. The knee jerk and other tendon reflexes.
- The secret life of James Parkinson (1755-1824): the writings of Old Hubert.
- Molecular pathogenesis of neurotropic viral infections.
- Classics in neurology. Fragments of neurologic history: pseudohypertrophic muscular dystrophy and Gowers' sign.
- Classics in neurology. Fragments of neurologic history: "Tetanoid Chorea" and progressive lenticular degeneration.
- Charles Edouard Brown-Séquard: professor of physiology and pathology of the nervous system at Harvard Medical School.
- Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
- Twenty-eight years of benign recurring Mollaret meningitis.
- Serious methodological failures concerning presence of HSV DNA in surgical tissue from human epileptic seizure foci detected by PCR.
- Human transmissible neurodegenerative Diseases (prion Diseases).
- Part 2: history of 20th century neurology: decade by decade.
- The Goltz-Ferrier debates and the triumph of Cerebral localizationalist theory.
- The shorthand publications of Sir William Richard Gowers.
- Prions' travels--feces and transmission of prion Diseases.
- Reoviruses and the host cell.
- Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus.
- Polymerase chain reaction and the diagnosis of viral central nervous system Diseases.
- Molecular and genetic aspects of the pathogenesis of viral infections of the central nervous system.
- West Nile virus encephalitis in America.
- Prions and prion Diseases of the central nervous system.
- Medical medullary syndrome and meningovascular syphilis: a case report in an HIV-infected man and a review of the literature.
- Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
- Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts.
- Molecular diagnosis of CNS viral infections.
- Pathogenesis of reovirus infections of the central nervous system.
- Herpes simplex virus infection as a cause of benign recurrent lymphocytic meningitis.
- Distinct pathways of viral spread in the host determined by reovirus S1 gene segment.
- Mechanisms of apoptosis during reovirus infection.
- MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation.
- Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation.
- Role of immune cells in protection against and control of reovirus infection in neonatal mice.
- A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice.
- Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
- Diffusion-weighted MRI abnormalities as a clue to the diagnosis of herpes simplex encephalitis.
- Eradication of persistent reovirus infection from a B-cell hybridoma.
- Cellular and humoral immunity to reovirus infection.
- Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid.
- Apoptosis and the cytopathic effects of reovirus.
- One and one-half syndrome with supranuclear facial weakness: magnetic resonance imaging localization.
- Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with a rapid sequencing technique.
- Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).
- Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases.
- Molecular basis of viral neurotropism: experimental reovirus infection.
- Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system.
- Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system.
- Polymerase chain reaction in the diagnosis and management of central nervous system infections.
- Reovirus-induced apoptosis requires both death receptor- and mitochondrial-mediated caspase-dependent pathways of cell death.
- Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing).
- Lymphocytes protect against and are not required for reovirus-induced myocarditis.
- Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action.
- Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1.
- HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy.
- Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes.
- Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2.
- Profound cerebrospinal fluid pleocytosis and Froin''s Syndrome secondary to widespread necrotizing vasculitis in an HIV-positive patient with varicella zoster virus en...
- Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis.
- Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection.
- Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors.
- Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF.
- Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis.
- Calpain inhibition protects against virus-induced apoptotic myocardial injury.
- Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis.
- Reovirus-induced apoptosis is mediated by TRAIL.
- Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.
- Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.
- Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.
- Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2).
- Reovirus-induced apoptosis: A minireview.
- Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.
- CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis.
- Comment: PML and adhesion molecule therapy.
- Neuro-intensive care of patients with acute CNS infections.
- Issues and updates in emerging neurologic viral infections.
- Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection.
- Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis.
- The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis.
Schools
Johns Hopkins University School Of Medicine
Massachusetts General Hospital Program
Harvard Med SchoolBoston
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Ataxia
- Cerebral Artery Thrombosis
- Convulsions
- Dementia
- View All
Doctors Specialties
- Internal Medicine
- Neurology
Accepted Insurances
Awards
- Regional Top Doctor
- Elected Fellow
- 40th Aird Professor
- Elected Member
- Chair
- Lippard Lecturer
- Landau Lecturer
- Associate Editor
- Editorial Board
Education
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Massachusetts General Hospital -
Brigham and Women's Hospital -
Johns Hopkins University School of Medicine
Hospital
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University of Colorado Hospital
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