Tenured Professor Clinical Director Molecular Medicine George Mason University, Virginia
Pathology
Dr. Lance A. Liotta, MD
Lance A. Liotta works in the field of Pathology. He studied medicine at Case Western Reserve University School of Medicine. Lance Liotta is a published physician. He published 101 publications, including: 'Use of a Chagas Urine Nanoparticle Test (Chunap) to Correlate with Parasitemia Levels in T. cruzi/HIV Co-infected Patients.'
Publications
- Impact of upfront cellular enrichment by laser capture microdissection on protein and phosphoprotein drug target signaling activation measurements in human lung cancer...
- Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells.
- Use of a novel chagas urine nanoparticle test (chunap) for diagnosis of congenital chagas disease.
- Functional characterization of epithelial ovarian cancer histotypes by drug target-based protein signaling activation mapping: implications for personalized cancer the...
- A pilot study utilizing multi-omic molecular profiling to find potential targets and select individualized treatments for patients with previously treated metastatic b...
- The use of Nanotrap particles for biodefense and emerging infectious disease diagnostics.
- Realizing the promise of reverse phase protein arrays for clinical, translational and basic research : a workshop report.
- Pilot Phase I/II Personalized Therapy Trial for Metastatic Colorectal Cancer: Evaluating the Feasibility of Protein Pathway Activation Mapping for Stratifying Patients...
- Application of molecular technologies for phosphoproteomic analysis of clinical samples.
- Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.
- Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells.
- Cancer metabolism and mass spectrometry-based proteomics.
- Dynamic protein pathway activation mapping of adipose-derived stem cell differentiation implicates novel regulators of adipocyte differentiation.
- Elevated TNFR1 and Serotonin in Bone Metastasis Are Correlated with Poor Survival following Bone Metastasis Diagnosis for Both Carcinoma and Sarcoma Primary Tumors.
- Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations.
- Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells.
- Attacking breast cancer at the preinvasion stage by targeting autophagy.
- Laser capture microdissection for protein and NanoString RNA analysis.
- A Proteomic Analysis of Eccrine Sweat: Implications for the Discovery of Schizophrenia Biomarker Proteins.
- Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods.
- Small business development for molecular diagnostics.
- Regulatory approval pathways for molecular diagnostic technology.
- Inventions and patents: a practical tutorial.
- Proteomic analysis reveals Warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells.
- Multifunctional Core-Shell Nanoparticles: Discovery of Previously Invisible Biomarkers.
- Cancer Biomarkers: Closer to Delivering on their Promise.
- Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways.
- Protein Pathway Activation Mapping of Brain Metastasis from Lung and Breast Cancers Reveals Organ Type Specific Drug Target Activation.
- Proteomic analysis of pancreatic ductal adenocarcinoma cells reveals metabolic alterations.
- Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data.
- Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry.
- Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.
- Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer.
- Reverse phase protein microarrays: fluorometric and colorimetric detection.
- Phosphoprotein stability in clinical tissue and its relevance for reverse phase protein microarray technology.
- Reverse phase protein microarrays for clinical applications.
- One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens.
- Mass spectrometry-based protein biomarker discovery: solving the remaining challenges to reach the promise of clinical benefit.
- Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells.
- Synthesis and characterization of hydrogel particles containing Cibacron Blue F3G-A.
- Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing.
- Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival.
- The Heme Degradation Pathway is a Promising Serum Biomarker Source for the Early Detection of Alzheimer's Disease.
- An initial characterization of the serum phosphoproteome.
- Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery.
- Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability.
- Pathway biomarker profiling of localized and metastatic human prostate cancer reveal metastatic and prognostic signatures.
- Activated VEGF receptor shed into the vitreous in eyes with wet AMD: a new class of biomarkers in the vitreous with potential for predicting the treatment timing and m...
- Application of laser microdissection and reverse-phase protein microarrays to the molecular profiling of cancer signal pathway networks in the tissue microenvironment.
- Application of physicochemically modified silicon substrates as reverse-phase protein microarrays.
- Reverse-phase protein microarrays for theranostics and patient tailored therapy.
- Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.
- Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers.
- Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles.
- Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation...
- A portrait of tissue phosphoprotein stability in the clinical tissue procurement process.
- Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy.
- Putting the "bio" back into biomarkers: orienting proteomic discovery toward biology and away from the measurement platform.
- Smart hydrogel particles: biomarker harvesting: one-step affinity purification, size exclusion, and protection against degradation.
- Molecular network analysis using reverse phase protein microarrays for patient tailored therapy.
- Reverse phase protein microarrays for theranostics and patient-tailored therapy.
- Automated laser capture microdissection for tissue proteomics.
- Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.
- Serum proteomic analysis identifies a highly sensitive and specific discriminatory pattern in stage 1 breast cancer.
- A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signali...
- The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology.
- A novel, high-throughput workflow for discovery and identification of serum carrier protein-bound peptide biomarker candidates in ovarian cancer samples.
- Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival.
- Tumor vascular proteins as biomarkers in ovarian cancer.
- Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells.
- Reverse phase protein microarrays for monitoring biological responses.
- Secreted neutral metalloproteases of Bacillus anthracis as candidate pathogenic factors.
- Breast cancer growth prevention by statins.
- Identification and characterization of endogenous Langerin ligands in murine extracellular matrix.
- Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironment.
- Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma.
- Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling.
- Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold.
- Laser capture microdissection.
- Manual exfoliation of fresh tissue obviates the need for frozen sections for molecular profiling.
- Analysis of albumin-associated peptides and proteins from ovarian cancer patients.
- Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma.
- A transforming growth factor-beta receptor-interacting protein frequently mutated in human ovarian cancer.
- Physiological mechanisms of tumor-cell invasion and migration.
- Mapping molecular networks using proteomics: a vision for patient-tailored combination therapy.
- Pegylated, steptavidin-conjugated quantum dots are effective detection elements for reverse-phase protein microarrays.
- Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis.
- Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
- Importance of communication between producers and consumers of publicly available experimental data.
- Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy.
- Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.
- Pathology of the future: molecular profiling for targeted therapy.
- Proteomic analysis of human breast cancer tissue with laser-capture microdissection and reverse-phase protein microarrays.
- Expression microdissection: operator-independent retrieval of cells for molecular profiling.
- Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate specific antigen levels between 2.5 and 15.0 ng/ml.
- A functional polymorphism in RGS6 modulates the risk of bladder cancer.
- Opportunities for nanotechnology-based innovation in tissue proteomics.
- Clinical proteomics: Applications for prostate cancer biomarker discovery and detection.
- Clinical proteomics and biomarker discovery.
- Use of a Chagas Urine Nanoparticle Test (Chunap) to Correlate with Parasitemia Levels in T. cruzi/HIV Co-infected Patients.
Schools
Case Western Reserve University School of Medicine
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
-
National Institutes of Health Clinical Center -
Case Western Reserve University School of Medicine
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