Professor of Pediatrics, University Tex Houston
Pediatric Hematology & Oncology
Dr. Laurence Cooper, MD
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Dr. Laurence Cooper works in the field of Pediatric Hematology & Oncology. He went to medical school at Case Western Reserve University School of Medicine. He has 4 awards "America's Top Doctors", "Top Doctors:SE Texas", "America's Top Doctors for Cancer" and "Elected Member". Laurence Cooper is also a published doctor. He has 100 paper published. The most recent paper is: Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable...
Publications
- Stable, non-viral expression of mutated tumor neoantigen-specific T-cell receptors using the Sleeping Beauty transposon/transposase system.
- Chimeric antigen receptor T cells targeting HERV-K inhibit breast cancer and its metastasis through downregulation of Ras.
- Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor.
- Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation.
- Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.
- Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells.
- Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies.
- Progress in Novel Cellular Therapy Options for Chronic Lymphocytic Leukemia: The MD Anderson Perspective.
- T-cell immunotherapy: looking forward.
- The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors.
- Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes.
- Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
- Is there an expiration date for a cord blood unit in storage?
- Universal artificial antigen presenting cells to selectively propagate T cells expressing chimeric antigen receptor independent of specificity.
- Driving CAR-Based T-Cell Therapy to Success.
- The development of a myeloablative, reduced-toxicity, conditioning regimen for cord blood transplantation.
- Third-party umbilical cord blood-derived regulatory T cells prevent xenogenic graft-versus-host disease.
- A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19.
- Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment.
- Immunotherapy for chronic lymphocytic leukemia in the era of BTK inhibitors.
- Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
- Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy.
- Growth and activation of natural killer cells ex vivo from children with neuroblastoma for adoptive cell therapy.
- Chimeric Antigen Receptor (CAR)-Specific Monoclonal Antibody to Detect CD19-Specific T Cells in Clinical Trials.
- CARs in Chronic Lymphocytic Leukemia - Ready to Drive.
- Clinical application of sleeping beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood.
- Sleeping beauty system to redirect T-cell specificity for human applications.
- Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy.
- Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous ?? T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor.
- Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64.
- Outcomes of second allogeneic hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia.
- Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System.
- Clinical applications of gamma delta T cells with multivalent immunity.
- Activation and Propagation of Tumor-infiltrating Lymphocytes on Clinical-grade Designer Artificial Antigen-presenting Cells for Adoptive Immunotherapy of Melanoma.
- Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.
- Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity.
- Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable...
- RBC T activation and hemolysis: implications for pediatric transfusion management.
- Evidence that juvenile myelomonocytic leukemia can arise from a pluripotential stem cell.
- PET imaging of T cells derived from umbilical cord blood.
- The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.
- Identifying candidate allogeneic NK-cell donors for hematopoietic stem-cell transplantation based on functional phenotype.
- Adoptive cellular immunotherapy for childhood malignancies.
- Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials.
- Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells.
- Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy for lymphoma.
- Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes.
- Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals.
- Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy.
- Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing.
- Antigen-independent and antigen-dependent methods to numerically expand CD19-specific CD8+ T cells.
- Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy.
- Lymphoid reconstruction and vaccines.
- CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.
- Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy.
- Enhancing siRNA effects in T cells for adoptive immunotherapy.
- T-cell genetic modification for re-directed tumor recognition.
- A quantitative high-throughput chemotaxis assay using bioluminescent reporter cells.
- Amplification of RNAi--targeting HLA mRNAs.
- Biophotonic cytotoxicity assay for high-throughput screening of cytolytic killing.
- Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
- Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1.
- Enhanced transgene expression in quiescent and activated human CD8+ T cells.
- Development and application of CD19-specific T cells for adoptive immunotherapy of B cell malignancies.
- Off-the-shelf T-cell therapy.
- Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.
- A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells.
- Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.
- Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies.
- Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in hum...
- Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
- Immunotherapy targeting EBV-expressing lymphoproliferative diseases.
- Test-driving CARs.
- Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system.
- Immunotherapy for pediatric cancer.
- Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infectio...
- A transposon and transposase system for human application.
- Advancement of pediatric blood and marrow transplantation research in North America: priorities of the Pediatric Blood and Marrow Transplant Consortium.
- piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.
- New approaches to allogeneic hematopoietic stem cell transplantation in pediatric cancers.
- Genome-wide mapping of PiggyBac transposon integrations in primary human T cells.
- Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography...
- Persuading natural killer cells to eliminate bad B cells.
- Highlights of the First International "Immunotherapy in Pediatric Oncology: Progress and Challenges" Meeting.
- Genetically modified T cells targeting interleukin-11 receptor ?-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metasta...
- Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies.
- Highlights of the second international conference on "Immunotherapy in Pediatric Oncology".
- Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
- Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies.
- Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010.
- T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect.
- Allogeneic transplantation for pediatric acute lymphoblastic leukemia: the emerging role of peritransplantation minimal residual disease/chimerism monitoring and novel...
- Adoptive T-cell therapy improves treatment of canine non-Hodgkin lymphoma post chemotherapy.
- Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells.
- Chimeric antibody receptors (CARs): Driving T-cell specificity to enhance anti-tumor immunity.
- Imaging of T cells expressing chimeric antigen receptors.
- CARs on track in the clinic.
- Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.
- Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.
Schools
Case Western Reserve University School of Medicine
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Blue Choice
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- ODS Health Plan
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- America's Top Doctors
- Top Doctors:SE Texas
- America's Top Doctors for Cancer
- Elected Member
Education
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University of Washington -
Case Western Reserve University School of Medicine
Hospital
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University of Texas M.D. Anderson Cancer Center
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