Physician
Oncology
Dr. Leonard A. Zwelling, MD
|
|
Give Review
Leonard Zwelling works in the field of Oncology. He went to Duke University School of Medicine. Duke University School of Medicine is a one of the best medicals schools. Duke University School of Medicine is ranked 8 in research and 29 in primary care medicine He received 12 awards: "Spirit of Service Award", "Outstanding CPE Recipient", "Salute to Excellence Award", "Robert Wood Johnson Foundation Health Policy Fellow", "Elected Member", "Dean's Teaching Excellence Award for Internal Medicine", "Fellow", "Beta Gamma Sigma-National Honorary", "Undergraduate Chemistry Honorary", "Engel Society", "Phi Beta Kappa" and "Phi Eta Sigma". Dr. Leonard A. Zwelling is a published doctor and has 100 publications published. The lastest was: 'Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide.'
Publications
- Obamacare: why should we care?
- Cancer research in the United States: dying by a thousand paper cuts.
- Cancer drug prices and the free-market forces.
- Cancer Drugs in the United States: Justum Pretium--The Just Price.
- The anticipated and unintended consequences of the patient protection and affordable care act on cancer research.
- Strategies for the administration of a clinical trials infrastructure: lessons from a comprehensive cancer center.
- Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells.
- Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia.
- Topotecan in chronic lymphocytic leukemia.
- Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells.
- Removal of os supranaviculare from a runner''s painful foot: a case report.
- Hypersthenuria in high-dose carbenicillin therapy.
- Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of...
- Components of intrinsic drug resistance in the rat hepatoma.
- Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.
- N-(5,5-diacetoxypentyl)doxorubicin: a novel anthracycline producing DNA interstrand cross-linking and rapid endonucleolytic cleavage in human leukemia cells.
- The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
- Liblomycin-mediated DNA cleavage in human head and neck squamous carcinoma cells and purified DNA.
- Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase II gene expression in human leukemia cells.
- A lack of detectable modification of topoisomerase II activity in a series of human tumor cell lines expressing only low levels of etoposide resistance.
- Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug a...
- HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive to...
- A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.
- Embryotoxicity of the intercalating agents m-AMSA and o-AMSA and the epipodophyllotoxin VP-16 in postimplantation rat embryos in vitro.
- Phorbol ester effects on topoisomerase II activity and gene expression in HL-60 human leukemia cells with different proclivities toward monocytoid differentiation.
- Enhancement of murine tumor cell sensitivity to adriamycin by presentation of the drug in phosphatidylcholine-phosphatidylserine liposomes.
- Intercalator-induced, topoisomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites.
- Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line.
- Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol.
- Leucine zipper in human DNA topoisomerase II.
- Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.
- Lithium chloride stimulates human monocytes to secrete tumor necrosis factor/cachectin.
- Topoisomerase II as a target of antileukemia drugs: a review of controversial areas.
- Topoisomerase II as a target of antileukemic drugs.
- Cell cycle stage dependent variations in drug-induced topoisomerase II mediated DNA cleavage and cytotoxicity.
- Effect of polyamine depletion by alpha-difluoromethylornithine or (2R,5R)-6-heptyne-2,5-diamine on drug-induced topoisomerase II-mediated DNA cleavage and cytotoxicity...
- Effect of 1-beta-D-arabinofuranosylcytosine (ara-C) on nuclear topoisomerase II activity and on the DNA cleavage and cytotoxicity produced by 4''-(9-acridinylamino)met...
- Receptors and topoisomerase one protein, two functions, not always.
- Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
- Anion-dependent modulations of DNA topoisomerase II-mediated reactions in potassium-containing solutions.
- Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon...
- Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.
- DNA topoisomerase II as a target of antineoplastic drug therapy.
- Reduced formation of protein-associated DNA strand breaks in Chinese hamster cells resistant to topoisomerase II inhibitors.
- Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei.
- Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage an...
- The production of topoisomerase II-mediated DNA cleavage in human leukemia cells predicts their susceptibility to 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA).
- Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II.
- Effect of cell proliferation and chromatin conformation on intercalator-induced, protein-associated DNA cleavage in human brain tumor cells and human fibroblasts.
- In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia.
- The interaction between nuclear topoisomerase II activity from human leukemia cells, exogenous DNA, and 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) or 4-(4...
- Cisplatin and new platinum analogs.
- A possible role for altered poly(adenosine diphosphoribose)-synthesis in the sensitivity of human head and neck squamous carcinoma cells to ionizing radiation.
- Effects of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin and doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukemia cells in vitro.
- Activation of monocyte-mediated tumoricidal activity in patients with acquired immunodeficiency syndrome.
- Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.
- Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters.
- Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.
- Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents.
- Defective monocyte killing in patients with malignancies and restoration of function during chemotherapy.
- Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
- Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro.
- Enhancement of the DNA breakage and cytotoxic effects of intercalating agents by treatment with sublethal doses of 1-beta-D-arabinofuranosylcytosine or hydroxyurea in ...
- Enhancement of intercalator-induced deoxyribonucleic acid scission and cytotoxicity in murine leukemia cells treated with 5-azacytidine.
- Protein-associated intercalator-induced DNA scission is enhanced by estrogen stimulation in human breast cancer cells.
- Effects of dimethyl sulfoxide and thiourea upon intercalator-induced DNA single-strand breaks in mouse leukemia (L1210) cells.
- Enhancement of naturally occurring human spontaneous monocyte-mediated cytotoxicity by cis-diamminedichloroplatinum(II).
- Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks.
- Atypical herpes simplex (HSV) infection in a patient with Hodgkin's disease.
- Absence of swiveling at sites of intercalator-induced protein-associated deoxyribonucleic acid strand breaks in mammalian cell nucleoids.
- Changes in deoxyribonucleic acid linking number due to treatment of mammalian cells with the intercalating agent 4'-(9-acridinylamino)methanesulfon-m-anisidide.
- Absence of a requirement for long-range DNA torsional strain in the production of protein-associated DNA strand breaks in isolated mammalian cell nuclei by the DNA int...
- Quenching of DNA:platinum(II) monoadducts as a possible mechanism of resistance to cis-diamminedichloroplatinum(II) in L1210 cells.
- Thiourea prevents cytotoxicity and mutagenicity, but not sister-chromated exchanges in V79 cells treated with cis-diaminedichloroplatinum (II).
- Ataxia-telangiectasia cells are not uniformly deficient in poly(ADP-ribose) synthesis following X-irradiation.
- The reconstitution of higher-order DNA structure after X-irradiation of mammalian cells.
- Comparison of DNA scission and cytotoxicity produced by Adriamycin and 5-iminodaunorubicin in human colon carcinoma cells.
- Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m...
- Effect of L-phenylalanine mustard, adriamycin, actinomycin D, and 4'-(9-acridinylamino)methanesulfon-m-anisidide on naturally occurring human spontaneous monocyte-medi...
- Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.
- DNA-repair deficiencies do not affect intercalator-induced cytotoxicity or DNA scission in human cells.
- Phase I-II study of m-AMSA administered as a continuous infusion.
- Cooperative sequestration of m-AMSA in L1210 cells.
- Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.
- Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose).
- The formation and resealing of intercalator-induced DNA strand breaks in isolated L1210 cell nuclei.
- Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium.
- DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.
- Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis-diamminedichloroplatinum(II).
- Comparative studies of DNA cross-linking and cytotoxicity in Burkitt's lymphoma cell lines treated with cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.
- Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.
- Biochemical pharmacology of penclomedine (NSC-338720).
- Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H- pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxy...
- Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II.
- Further characterization of an amsacrine-resistant line of HL-60 human leukemia cells and its topoisomerase II. Effects of ATP concentration, anion concentration, and ...
- Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.
- The effect of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 1-beta-D-arabinofuranosylcytosine on the cell cycle phase distribution, topoisomerase II level, mitoxantron...
- Strategic service quality management for health care.
- Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide.
Schools
Duke Univ Sch Of Med
Duke University Med Center
National Cancer Institute
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- Spirit of Service Award
- Outstanding CPE Recipient
- Salute to Excellence Award
- Robert Wood Johnson Foundation Health Policy Fellow
- Elected Member
- Dean's Teaching Excellence Award for Internal Medicine
- Fellow
- Beta Gamma Sigma-National Honorary
- Undergraduate Chemistry Honorary
- Engel Society
- Phi Beta Kappa
- Phi Eta Sigma
Education
-
Duke University Hospital -
Duke University School of Medicine -
Duke University
Hospital
-
University of Texas M.D. Anderson Cancer Center
Helpful Reviews
Similar Doctors
|
|
Dr. Christopher J. Logothetis, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Larry W. Kwak, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. James L. Abbruzzese, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Bhuvana Sagar, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Francesco Turturro, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Khaled W. Jabboury, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Stacy L. Moulder, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amado J. Zurita-Saavedra, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Ana-Maria Gonzalez-Angulo, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert Z. Orlowski, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Arlene O. Siefker-Radtke, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Tejal A. Patel, MD
This Doctor is OpenDoctor Recommended.
|