Rainier Clinical Research Center
Endocrinology
Dr. Leslie J. Klaff, MD
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Dr. Leslie J. Klaff is an expert in the field of Endocrinology. He has 2 awards "Fellow (FACE)" and "Fellow (FRCP) Edin". Leslie Klaff is a published physician. He has 51 papers published. The most current publication "Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat."
Publications
- Fundamental Importance of Reference Glucose Analyzer Accuracy for Evaluating the Performance of Blood Glucose Monitoring Systems (BGMSs).
- The Performance and Usability of a Factory-Calibrated Flash Glucose Monitoring System.
- Accuracy Evaluation of Contour Next Compared with Five Blood Glucose Monitoring Systems Across a Wide Range of Blood Glucose Concentrations Occurring in a Clinical Res...
- Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes.
- Effect of sitagliptin on post-prandial glucagon and GLP-1 levels in patients with type 1 diabetes: investigator-initiated, double-blind, randomized, placebo-controlled...
- The incidence and causes of hypercalcaemia.
- A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.
- Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat.
- Effect of 14 days'' subcutaneous administration of the human amylin analogue, pramlintide (AC137), on an intravenous insulin challenge and response to a standard liqui...
- The effect of aspirin and anti-ulcer drugs on gastric mucosal prostaglandin E.
- Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study.
- Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin.
- Comparative glycemic control, safety and patient ratings for a new 4 mm x 32G insulin pen needle in adults with diabetes.
- Postprandial versus preprandial dosing of biphasic insulin aspart in elderly type 2 diabetes patients.
- In vitro release of cholecystokinin octapeptide-like immunoreactivity from rat brain synaptosomes.
- Measurement of human serum parathyroid hormone in disorders of calcium metabolism and during administration of certain gut hormones.
- Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma.
- Synthetic luteinizing hormone-releasing hormone in impotent male diabetics.
- Syndrome of inappropriate antidiuretic hormone secretion in association with herpes zoster of the chest wall. A case report.
- Sulfonylureas and platelet function.
- Comparative study of pancreatic polypeptide (PP) secretion, endocrine and exocrine function, and structural damage in chronic alcohol induced pancreatitis (CAIP).
- Failure of calcium infusion as a provocative test for insulinoma.
- Arginine hydrochloride stimulation of serum potassium and aldosterone is enhanced by somatostatin-28.
- Inhibition of pancreatic hormone secretion by somatostatin-28 and somatostatin-14 in man.
- Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man.
- Somatostatin-28 inhibits thyroid-stimulating hormone release in man.
- Somatostatin-28 inhibits LHRH-stimulated gonadotrophin secretion in man.
- A method for studying synaptosomal release of neurotransmitter candidates, as evaluated by studies on cortical cholecystokinin octapeptide release.
- Pancreatic polypeptide response to exercise. Effect of alanine and glucose ingestion in carbohydrate-starved athletes.
- Insulin autoantibodies at diagnosis of insulin-dependent diabetes: effect on the antibody response to insulin treatment.
- Defects in beta-cell function and insulin sensitivity in normoglycemic streptozocin-treated baboons: a model of preclinical insulin-dependent diabetes.
- Somatostatin-28 does not regulate islet function in the dog.
- Role of pancreatic somatostatin in determining glucagon response to arginine and morphine.
- Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia.
- Pancreatic somatostatinoma: presentation with recurrent episodes of severe hyperglycaemia and ketoacidosis.
- Responses of the pancreatic A cell during hypoglycemia and hyperglycemia are dependent on the B cell.
- Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.
- Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats.
- Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study.
- Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.
- Increased specificity and sensitivity of insulin antibody measurements in autoimmune thyroid disease and type I diabetes.
- Treatment of paraquat poisoning with the membrane oxygenator: a case report.
- Circulating antibodies in diabetics treated with conventional and purified insulins.
- Pulmonary effects of contact exposure to paraquat: a clinical and experimental study.
- Effects of the sulphonylurea drugs gliclazide and glibenclamide on blood glucose control and platelet function.
- Initiating insulin therapy in elderly patients with Type 2 diabetes: efficacy and safety of lispro mix 25 vs. basal insulin combined with oral glucose-lowering agents.
- The effect of pramlintide on hormonal, metabolic or symptomatic responses to insulin-induced hypoglycaemia in patients with type 1 diabetes.
- Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.
- Beta-cell function and insulin sensitivity in nondiabetic HLA-identical siblings of insulin-dependent diabetics.
- Risks for glucose intolerance.
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Fellow (FACE)
- Fellow (FRCP) Edin
Education
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University of the Witwatersrand
Hospital
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University of Washington Medical Center
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