Professor, Pathology and Laboratory Medicine, UCLA School of Medicine
Pathology
Dr. Linda G. Baum, MD
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Linda Baum is an expert in the field of Pathology. She researched medicine at Duke University School of Medicine. Duke University School of Medicine is a one of the best medicals schools. Duke University School of Medicine has a rank of 8 in research and a 29 in primary care Linda Baum is a published doctor. She has 101 publications published. The most current publication "Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation." Linda Baum accepts Medicare payments and is listed with Medicare.gov.
Publications
- Galectins and Immune Responses-Just How Do They Do Those Things They Do?
- Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytia formation in endothelial cells.
- Comparison of Antibodies That Mediate HIV Type 1 gp120 Antibody-Dependent Cell-Mediated Cytotoxicity in Asymptomatic HIV Type 1-Positive Men and Women.
- Introduction to special issue: Sugars, bugs and us.
- The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy.
- Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death.
- Burn control, an adipocyte-specific function for galectin-12.
- Structural Aspects of Binding of {alpha}-Linked Digalactosides to Human Galectin-1.
- Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.
- N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death.
- Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.
- Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling.
- CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells.
- Suppression of autoimmune diabetes by soluble galectin-1.
- Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes.
- Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways.
- Galectins in the tumor endothelium: opportunities for combined cancer therapy.
- Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
- O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.
- Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.
- Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death.
- Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.
- Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death.
- Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans.
- Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix.
- Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells.
- Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration.
- N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.
- Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death.
- Galectin interactions with extracellular matrix and effects on cellular function.
- Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflamm...
- A self-assembled multivalent pseudopolyrotaxane for binding galectin-1.
- An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas.
- Presentation of galectin-1 by extracellular matrix triggers T cell death.
- Insect galectins: roles in immunity and development.
- The X-lectins: a new family with homology to the Xenopus laevis oocyte lectin XL-35.
- Amelioration of graft versus host disease by galectin-1.
- Galectin-1-mediated apoptosis in mycosis fungoides: the roles of CD7 and cell surface glycosylation.
- The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death.
- Preparation of recombinant human galectin-1 and use in T-cell death assays.
- Dynamic regulation of T cell immunity by CD43.
- Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissues.
- Developing a taste for sweets.
- Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments.
- Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy.
- Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an...
- Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation.
- Degradation of proteins in the membrane-cytoskeleton complex in Alzheimer's disease. Might amyloidogenic APP processing be just the tip of the iceberg?
- Isolation and characterization of a galactose-specific carbohydrate binding protein from human lymphoblastic cells.
- Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement.
- APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men.
- Intravenous immunoglobulin inhibits natural killer cell activity in vivo in women with recurrent spontaneous abortion.
- C-reactive protein antigenicity on the surface of human lymphocytes.
- Effect of intravenous immunoglobulin G on natural killer cell cytotoxicity in vitro in women with recurrent spontaneous abortion.
- Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology.
- Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.
- Novel TIGR sequence alteration Val53Ala.
- Run-on mutation and three novel nonsense mutations identified in the PAX6 gene in patients with aniridia.
- Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit.
- Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity.
- Gene mutations in retinitis pigmentosa and their clinical implications.
- Assessing the roles of galectins in regulating dendritic cell migration through extracellular matrix and across lymphatic endothelial cells.
- Microbe-Host Interactions are Positively and Negatively Regulated by Galectin-Glycan Interactions.
- The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins.
- Galectin multimerization and lattice formation are regulated by linker region structure.
- Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling.
- Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity.
- The emerging field of glycoimmunology: highlights from the Society for Glycobiology meeting, 2006.
- 1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer.
- Sialic acids in T cell development and function.
- Glycoimmunology: ignore at your peril!
- Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
- Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis.
- Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes.
- T-cell activation results in microheterogeneous changes in glycosylation of CD45.
- New roles for galectins in brain tumors--from prognostic markers to therapeutic targets.
- Women editors: change comes from focused action.
- Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death.
- Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?
- Ah, sweet mystery of death! Galectins and control of cell fate.
- Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions.
- CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans.
- Apoptosis of T cells mediated by galectin-1.
- Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector/memory CD8+ T cells from naive cells.
- Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation.
- Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.
- Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1.
- CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death.
- Human homologs of the Xenopus oocyte cortical granule lectin XL35.
- Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation.
- Galectin-1 is expressed by thymic epithelial cells in myasthenia gravis.
- Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression.
- Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes.
- Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death.
- CD45 glycosylation controls T-cell life and death.
- Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells.
- Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans.
- Regulation of alpha 2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (PNA)+ to PNA- phenotype in developing thymocytes.
- Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death.
- Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.
Schools
Duke University
UCLA Med Center
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Education
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UCLA Medical Center -
Duke University School of Medicine
Hospital
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Ronald Reagan UCLA Medical Center
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