Professor, Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center
Pediatric Endocrinology
Dr. Louis J. Muglia, MD
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Louis Muglia practices Pediatric Endocrinology. He went to University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine He has 23 awards "Fellow", "James R. Givens Distinguished Visiting Professor", "Outstanding Faculty Mentor Award", "Best Doctors in America", "Kavli Fellow", "Special Recognition for Excellence in Mentoring", "Outstanding Teacher", "Elected Member", "Certificate of Recognition for Excellence in Mentoring", "Young Investigator Award", "Career Development Award in the Biomedical Sciences", "Travel Award", "Clinical Investigator Award", "Scholar", "Janeway Fellow", "Farley Fellow", "Graduation with Honors", "Alpha Omega Alpha", "Roesing Scholar", "Phi Beta Kappa", "Graduation with "Highest Distinction" for academic performance and "High Honors" for research", "NSF Undergraduate Fellowship in Medicinal Chemistry" and "James B. Angell Scholar". Louis J. Muglia is a published doctor. He has 100 papers published. The most current publication "Characterization of the mouse DAX-1 gene reveals evolutionary conservation of a unique amino-terminal motif and widespread expression in mouse tissue."
Publications
- GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes.
- Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis.
- Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation.
- Genomics of preterm birth.
- 50 years ago in the journal of pediatrics: the epidemiology of prematurity.
- Prevention of preterm birth: Harnessing science to address the global epidemic.
- Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice.
- Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis.
- Influenza vaccine in pregnancy: policy and research strategies.
- Disrupting Hypothalamic Glucocorticoid Receptors Causes HPA Axis Hyperactivity and Excess Adiposity.
- Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth.
- The genomics of preterm birth: from animal models to human studies.
- Amniotic Fluid: The Use of High-Dimensional Biology to Understand Fetal Well-Being.
- Candidate gene linkage approach to Identify DNA variants that predispose to preterm birth.
- Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU.
- Investigation of genetic risk factors for chronic adult diseases for association with preterm birth.
- Fetal programming and environmental exposures: implications for prenatal care and preterm birth.
- Site-specific modulation of brain glucocorticoid receptor and corticotropin-releasing hormone expression using lentiviral vectors.
- Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.
- Better by the Pound: The Genetics of Birth Weight.
- Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
- Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.
- Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.
- Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.
- Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
- TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages.
- Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice.
- Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory.
- Impaired steroidogenesis and implantation failure in Bmal1-/- mice.
- The correlation in birth timing between singleton and twin gestations in the same mother.
- Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment.
- Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain.
- Insights into parturition biology from genetically altered mice.
- A population-based study of race-specific risk for preterm premature rupture of membranes.
- Preterm birth in pregnancies complicated by major congenital malformations: a population-based study.
- Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning.
- Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.
- Heritability of parturition timing: an extended twin design analysis.
- A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing.
- DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.
- Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.
- Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism.
- Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.
- Glucocorticoids and the osteoclast.
- The imprinted gene Magel2 regulates normal circadian output.
- A short interpregnancy interval is a risk factor for preterm birth and its recurrence.
- Paternal race is a risk factor for preterm birth.
- Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.
- Risk for postterm delivery after previous postterm delivery.
- Racial disparity in the frequency of recurrence of preterm birth.
- Dexamethsone suppresses bone formation via the osteoclast.
- Oxytocin in the circadian timing of birth.
- Effects of genetically altered brain glucocorticoid receptor action on behavior and adrenal axis regulation in mice.
- Glucocorticoids suppress bone formation via the osteoclast.
- Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection.
- Inadvertent social information and the avoidance of parasitized male mice: a role for oxytocin.
- You are when you eat.
- Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness.
- Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.
- Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.
- Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.
- Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.
- Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior.
- Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.
- Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional re...
- Genetic dissection of stress response pathways in vivo.
- Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency.
- Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation.
- T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
- Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor.
- Microarray analysis of uterine gene expression in mouse and human pregnancy.
- An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice.
- The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development.
- Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.
- Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases.
- Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo.
- Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development.
- Coordinate regulation of prostaglandin metabolism for induction of parturition in mice.
- Ethanol-induced caspase-3 activation in the in vivo developing mouse brain.
- Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.
- COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.
- Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor.
- Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
- Genetic influences on preterm birth.
- Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need.
- Production of corticotropin-releasing hormone-deficient mice by targeted mutation in embryonic stem cells.
- Air Pollution and Stillbirth Risk: Exposure to Airborne Particulate Matter during Pregnancy Is Associated with Fetal Death.
- Characterization of the mouse DAX-1 gene reveals evolutionary conservation of a unique amino-terminal motif and widespread expression in mouse tissue.
- Identification, chromosomal mapping, and partial characterization of mouse InsI6: a new member of the insulin family.
- Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.
- Developmental regulation of albumin and alpha-fetoprotein gene expression in the rat.
- Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene.
- Extrapancreatic insulin gene expression in the fetal rat.
- Insulin-gene expression in extrafetal membranes of rats.
- Adjunctive therapies to cerclage for the prevention of preterm birth: a systematic review.
- Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity.
- Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study.
- Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia.
- Vasopressin stimulates ventromedial hypothalamic neurons via oxytocin receptors in oxytocin gene knockout male and female mice.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Children39s Hospital
Conditions Treated
- Hypothyroidism
Doctors Specialties
- Pediatric Endocrinology
Accepted Insurances
Awards
- Fellow
- James R. Givens Distinguished Visiting Professor
- Outstanding Faculty Mentor Award
- Best Doctors in America
- Kavli Fellow
- Special Recognition for Excellence in Mentoring
- Outstanding Teacher
- Elected Member
- Certificate of Recognition for Excellence in Mentoring
- Young Investigator Award
- Career Development Award in the Biomedical Sciences
- Travel Award
- Clinical Investigator Award
- Scholar
- Janeway Fellow
- Farley Fellow
- Graduation with Honors
- Alpha Omega Alpha
- Roesing Scholar
- Phi Beta Kappa
- Graduation with "Highest Distinction" for academic performance and "High Honors" for research
- NSF Undergraduate Fellowship in Medicinal Chemistry
- James B. Angell Scholar
Education
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Boston Children's Hospital -
University of Chicago Pritzker School of Medicine -
University of Michigan -
University of Chicago
Hospital
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Cincinnati Children's Hospital Medical Center
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