Professor and Chairman, Department of Neurological Surgery, Northwestern University Feinberg School of Medicine
Neurosurgery
Dr. Maciej S. Lesniak, MD
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Dr. Maciej S. Lesniak is an expert in the field of Neurosurgery. He went to medical school at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine is ranked 3 in research and 29 in primary care medicine He has 3 awards "CMS Meaningful Use Stage 1 Certification", "Fellow (FAANS)" and "Fellow (FACS)". Dr. Maciej S. Lesniak has written publications. He has 98 publications published with PubMed. The lastest paper is: 'Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma.'
Publications
- Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.
- Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma.
- MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells.
- Characterization and Functional Analysis of scFv-Based Cars to Redirect T Cells to IL13Rα2-Positive Glioma.
- Sui generis: gene therapy and delivery Systems for the treatment of glioblastoma.
- Blood-Brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.
- The role of IDO in Brain tumor immunotherapy.
- Analysis of glioblastoma Tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction.
- Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors.
- Advances in stem cells, induced pluripotent stem cells, and engineered cells: delivery vehicles for anti-glioma therapy.
- Therapeutic cell carriers: a potential road to cure glioma.
- Cytomegalovirus and glioma: putting the cart before the horse.
- The art of attraction: applications of multifunctional magnetic nanomaterials for malignant glioma.
- Delayed Administration of Bone Marrow Mesenchymal Stem Cell Conditioned Media Significantly Improves Outcome after Retinal Ischemia in Rats.
- Conversion of differentiated Cancer cells into Cancer stem-like cells in a glioblastoma model after primary chemotherapy.
- Development of Preclinical Models for Immunogene Therapy of Brain Cancer: It's Not Monkey Business!
- Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma.
- Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma.
- Chemokines in Tumor progression and metastasis.
- Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse Brain tumor model.
- Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors.
- Multifunctional nanoparticles for Brain tumor diagnosis and therapy.
- Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in Gliomas.
- The Timing of Neural Stem Cell-Based Virotherapy Is Critical for Optimal Therapeutic Efficacy When Applied With Radiation and Chemotherapy for the Treatment of Gliobla...
- Antiglioma oncolytic virotherapy: unattainable goal or a success story in the making?
- A preclinical evaluation of neural stem cell-based cell carrier for targeted antiglioma oncolytic virotherapy.
- Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy.
- N-acetylcysteine amide (NACA) Augments the Therapeutic Effect of Neural Stem Cell-Based Anti-Glioma Oncolytic Virotherapy.
- MicroRNA targeting as a therapeutic strategy against glioma.
- Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategies.
- Drug-loaded nanoparticle Systems and adult stem cells: a potential marriage for the treatment of malignant glioma?
- Anti-angiogenic therapy increases intraTumoral adenovirus distribution by inducing collagen degradation.
- Oncolytic virotherapy for malignant glioma: translating laboratory insights into clinical practice.
- WNT10B/?-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast Cancer.
- The art of gene therapy for glioma: a review of the challenging road to the bedside.
- MicroRNAs in Brain metastases: big things come in small packages.
- IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival.
- Recent developments on immunotherapy for Brain cancer.
- Maintaining and loading neural stem cells for delivery of oncolytic adenovirus to Brain tumors.
- Clinical significance of KISS1 protein expression for Brain invasion and metastasis.
- Thymus-derived rather than tumor-induced regulatory T cells predominate in Brain tumors.
- Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts.
- A Comparative Study of Neural and Mesenchymal Stem Cell-Based Carriers for Oncolytic Adenovirus in a Model of Malignant Glioma.
- Immunotherapy for Glioblastoma: The Devil Is in the Details.
- Neural Stem Cell-based Cell Carriers Enhance Therapeutic Efficacy of an Oncolytic Adenovirus in an Orthotopic Mouse Model of Human Glioblastoma.
- The expression of BST2 in human and experimental mouse Brain tumors.
- Cancer stem cells: the final frontier for glioma virotherapy.
- The challenge for gene therapy: innate immune response to adenoviruses.
- Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy.
- Enhanced Transduction and Replication of RGD-Fiber Modified Adenovirus in Primary T Cells.
- Bone marrow mesenchymal stem cells loaded with an oncolytic adenovirus suppress the anti-adenoviral immune response in the cotton rat model.
- What will anesthesiologists be anesthetizing? Trends in neurosurgical procedure usage.
- Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.
- Crossing the boundaries: stem cells and gene therapy.
- PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
- Biofunctionalized magnetic-vortex microdiscs for targeted Cancer-cell destruction.
- Challenges in clinical design of immunotherapy trials for malignant glioma.
- Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma.
- The presence of IL-17A and T helper 17 cells in experimental mouse Brain tumors and human glioma.
- A high-performance nanobio photocatalyst for targeted Brain cancer therapy.
- Cancer cell death by design: apoptosis, autophagy and glioma virotherapy.
- A tractography comparison between turboprop and spin-echo echo-planar diffusion tensor imaging.
- Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy.
- Low-dose radiation enhances survivin-mediated virotherapy against malignant glioma stem cells.
- Mesenchymal stem cells effectively deliver an oncolytic adenovirus to intracranial glioma.
- Current immunotherapeutic strategies for central Nervous system tumors.
- Targeting adenovirus to CD80 and CD86 receptors increases gene transfer efficiency to malignant glioma cells.
- Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antiTumor activity in established intracranial glioma.
- Comparative evaluation of survivin, midkine and CXCR4 promoters for transcriptional targeting of glioma gene therapy.
- Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 chain permits effective gene transfer to malignant glioma.
- Gene therapy trials for the treatment of high-grade Gliomas.
- Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental Brain tumors.
- Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental Brain tumors.
- Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus.
- An increase in CD4+CD25+FOXP3+ regulatory T cells in Tumor-infiltrating lymphocytes of human glioblastoma multiforme.
- CD46 represents a target for adenoviral gene therapy of malignant glioma.
- The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma.
- Oncolytic adenoviral therapy for glioblastoma multiforme.
- Novel advances in drug delivery to Brain cancer.
- Percival Bailey and the classification of Brain tumors.
- Multicentric parenchymal xanthogranuloma in a child: case report and review of the literature.
- Should the diagnosis of benign prostatic hyperplasia be made on prostate needle biopsy?
- The potential of polymeric micelles in the context of glioblastoma therapy.
- New approach to the rehabilitation of post-Stroke focal cognitive syndrome: effect of levodopa combined with speech and language therapy on functional recovery from ap...
- Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
- Low pressure Hydrocephalus and ventriculomegaly: hysteresis, non-linear dynamics, and the benefits of CSF diversion.
- Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges.
- Characterization of infectivity of knob-modified adenoviral vectors in glioma.
- MDA-7/IL-24 as a Cancer therapeutic: from bench to bedside.
- Drug delivery to tumors of the central Nervous system.
- Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo.
- Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo.
- Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats.
- Comparative analysis of paracrine immunotherapy in experimental Brain tumors.
- Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental Brain tumors.
- Targeted therapy for Brain tumours.
- Surgical outcome following resection of contrast-enhanced pediatric Brainstem gliomas.
Schools
Johns Hopkins University School Of Medicine
Johns Hopkins
Procedures Preformed
- Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Dural Repair or Other Spinal Spinal Cord Repair
- Herniated Disc Surgery
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Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FAANS)
- Fellow (FACS)
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
Hospital
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Northwestern Memorial Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1326103151 |
| Last Name Of The Provider | LESNIAK |
| First Name Of The Provider | MACIEJ |
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