Professor, Pathology, University of Texas Medical School, San Antonio
Pathology
Dr. Manjeri A. Venkatachalam, MD
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Manjeri Venkatachalam practices Pathology. He researched medicine at SUNY Upstate Medical University. He over the years received 1 awards: "Elected Member". Manjeri A. Venkatachalam has written publications. He has 98 publications published with PubMed. The lastest publication is: 'Mechanisms of cell death in hypoxia/reoxygenation injury.'
Publications
- Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression.
- Could Autophagic Exhaustion Be a Final Common Pathway for Podocytopathy in FSGS?
- Critical Blood Pressure Threshold Dependence of Hypertensive Injury and Repair in a Malignant Nephrosclerosis Model.
- Severe Renal Mass Reduction Impairs Recovery and Promotes Fibrosis after AKI.
- New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling.
- The conundrum of protection from AKI by adenosine in rodent clamp ischemia models.
- Tolerance of the human kidney to isolated controlled ischemia.
- Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death.
- Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent ...
- PI3K regulation of the SKP-2/p27 axis through mTORC2.
- Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.
- Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer.
- Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2.
- Acute kidney injury: a springboard for progression in chronic kidney disease.
- Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia.
- Calcium in cell injury and death.
- Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.
- Role of apoptosis in hypoxic/ischemic damage in the kidney.
- Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.
- Glycine protection of PC-12 cells against injury by ATP-depletion.
- Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release.
- Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia.
- A novel wounding device suitable for quantitative biochemical analysis of wound healing and regeneration of cultured epithelium.
- Regulation of the mitochondrial permeability transition in kidney proximal tubules and its alteration during hypoxia-reoxygenation.
- Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules.
- Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury.
- Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis.
- Glycine-protected, hypoxic, proximal tubules develop severely compromised energetic function.
- Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.
- Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury.
- Differential cytoprotection by glycine against oxidant damage to proximal tubule cells.
- Effects of Ca++ and glycine on lipid breakdown and death of ATP-depleted MDCK cells.
- Cytosolic-free calcium increases to greater than 100 micromolar in ATP-depleted proximal tubules.
- Mechanisms of cell death in hypoxia/reoxygenation injury.
- Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
- Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for glycine cytoprotection.
- Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation.
- Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates.
- Structural requirements for protection by small amino acids against hypoxic injury in kidney proximal tubules.
- Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels.
- Mechanisms of cell injury in ATP-depleted proximal tubules. Role of glycine, calcium, and polyphosphoinositides.
- Guanine nucleotides and acute renal failure.
- Conservation of structure in ATP-depleted proximal tubules: role of calcium, polyphosphoinositides, and glycine.
- Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.
- Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury.
- Heme oxygenase-1 in tissue pathology: the Yin and Yang.
- Contribution of actin cytoskeletal alterations to ATP depletion and calcium-induced proximal tubule cell injury.
- Intracellular Ca2+ thresholds that determine survival or death of energy-deprived cells.
- Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine.
- Modulation by Gly, Ca, and acidosis of injury-associated unesterified fatty acid accumulation in proximal tubule cells.
- Role of intracellular pH during cytoprotection of proximal tubule cells by glycine or acidosis.
- Energy thresholds that determine membrane integrity and injury in a renal epithelial cell line (LLC-PK1). Relationships to phospholipid degradation and unesterified fa...
- A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells.
- Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury.
- Apoptosis: definition, mechanisms, and relevance to disease.
- Calcium dependence of integrity of the actin cytoskeleton of proximal tubule cell microvilli.
- cDNA cloning and promoter analysis of rat caspase-9.
- Anionization of an antigen promotes glomerular binding and immune complex formation.
- Alanine protects rabbit proximal tubules against anoxic injury in vitro.
- Relationships between oxidant and non-oxidant mechanisms in the pathogenesis of acute renal failure.
- Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2, and S3 segments.
- Glomerular localization of platelet cationic proteins after immune complex-induced platelet activation.
- The role of platelets and polycationic mediators in glomerular vascular injury.
- Binding of platelet factor four (PF 4) to glomerular polyanion.
- Size and charge selective permeability defects induced in glomerular basement membrane by a polycation.
- Protein restriction or calorie restriction? A critical assessment of the influence of selective calorie restriction on the progression of experimental renal disease.
- Differential effects of calorie restriction on glomeruli and tubules of the remnant kidney.
- Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1.
- Lipid alterations induced by renal ischemia: pathogenic factor in membrane damage.
- Alterations in vascular function and morphology in acute ischemic renal failure.
- Potentiation of ischemic renal injury by amino acid infusion.
- Reversible inner medullary vascular obstruction in acute experimental hydronephrosis.
- Tubular leakage and obstruction after renal ischemia: structural-functional correlations.
- Mechanism of proximal tubule brush border loss and regeneration following mild renal ischemia.
- Structural differences in thin limbs of Henle: physiological implications.
- Characterization of rat kidney proximal tubule brush border membrane-associated phosphatidylinositol phosphodiesterase.
- Enhancement of glomerular immune complex deposition by a circulating polycation.
- Food restriction retards body growth and prevents end-stage renal pathology in remnant kidneys of rats regardless of protein intake.
- Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I.
- Glomerular filtration of proteins: clearance of anionic, neutral, and cationic horseradish peroxidase in the rat.
- Glomerular permeability of macromolecules. Effect of molecular configuration on the fractional clearance of uncharged dextran and neutral horseradish peroxidase in the...
- Regional membrane specialization in the thin limbs of Henle''s loops as seen by freeze-fracture electron microscopy.
- Glomerular permeability: in vivo tracer studies with polyanionic and polycationic ferritins.
- Lipid alterations in LLC-PK1 cells exposed to mercuric chloride.
- Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass.
- Cyclic AMP-associated shape change in mesangial cells and its reversal by prostaglandin E2.
- Myeloma kidney cast nephropathy in a rat model of multiple myeloma.
- Pathology and pathogenesis of nephrotoxic membrane damage.
- Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol-specific phospholipase C.
- Fine structural localization of peroxidase activity in the epithelium of large intestine of rat.
- Kidney complications.
- Salvage of ischemic cells by impermeant solute and adenosinetriphosphate.
- The structural and molecular basis of glomerular filtration.
- An ultrastructural study of glomerular permeability in aminonucleoside nephrosis using catalase as a tracer protein.
- Elevation of cAMP in cultured mesangial cells diminishes vasopressin-stimulated increases of phosphate uptake and 32P-specific activity in ATP but has no effect on pho...
- Ultrastructure of the local Arthus phenomenon using horseradish peroxidase as antigen.
- Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI.
Doctors Specialties
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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Boston University Medical Center -
SUNY Upstate Medical University
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