Professor of Pediatrics and Communicable Diseases; Director, Division of Pediatric Pulmonology
Pediatric Pulmonology
Dr. Marc B. Hershenson, MD
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Marc B. Hershenson works in the field of Pediatric Pulmonology. He researched medicine at University of Illinois College of Medicine. He has 6 awards "Elected to Best Doctors in America", "Frederick G.L. Huetwell Professor of Pediatrics and Communicable Diseases", "Career Development Award", "Clinical Investigator Award", "Young Investigator Award" and "Alpha Omega Alpha". Doctor Marc B. Hershenson, MD is a published doctor and has 99 publications published. The lastest was: 'Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.'
Publications
- Toward Primary Prevention of Asthma: Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma.
- Periostin is required for maximal airways inflammation and hyperresponsiveness in mice.
- Rhinovirus Infection Induces IL-13 Production from CD11b-positive, Exudative M2-polarized Exudative Macrophages.
- Amniotic fluid derived mesenchymal stromal cells augment fetal Lung growth in a nitrofen explant model.
- Reduced platelet-derived growth factor receptor expression is a primary feature of human Bronchopulmonary dysplasia.
- Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.
- Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.
- Paracrine regulation of fetal Lung morphogenesis using human placenta-derived mesenchymal stromal cells.
- Differential Responses to Rhinovirus and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis.
- Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide.
- Crumbs3 is essential for proper epithelial development and viability.
- Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans.
- Nasal cytokine responses to natural colds in Asthmatic children.
- MACROPHAGE/EPITHELIAL CELL CCL2 CONTRIBUTES TO RHINOVIRUS-INDUCED HYPERRESPONSIVENESS AND INFLAMMATION IN A MOUSE MODEL OF ALLERGIC AIRWAYS Disease.
- Periostin promotes fibrosis and predicts progression in patients with Idiopathic Pulmonary Fibrosis.
- Rhinovirus Attenuates Non-typeable Hemophilus Influenzae-stimulated IL-8 Responses via TLR2-dependent Degradation of IRAK-1.
- Glycogen synthase kinase-3β/β-catenin signaling regulates neonatal Lung mesenchymal stromal cell myofibroblastic differentiation.
- Quercetin inhibits rhinovirus replication in vitro and in vivo.
- IL-17-Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease.
- Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.
- MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness.
- Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.
- Mesenchymal Stromal Cells from Neonatal Tracheal Aspirates Demonstrate a Pattern of Lung-Specific Gene Expression.
- Longitudinal measures of lung function in infants with Bronchopulmonary dysplasia.
- Isolation of tracheal aspirate mesenchymal stromal cells predicts Bronchopulmonary dysplasia.
- Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.
- Increased cytokine response of rhinovirus-infected airway epithelial cells in Chronic obstructive pulmonary disease.
- Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase.
- Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal Lung mesenchymal stem cells.
- p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.
- Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in Cystic fibrosis transmembrane conductance regulator knockout mice.
- Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses.
- CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection.
- Elastase- and LPS-exposed mice display altered responses to rhinovirus infection.
- Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in Respiratory epithelial cells.
- Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of Asthma.
- Rhinovirus disrupts the barrier function of polarized airway epithelial cells.
- Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.
- Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.
- Airway smooth muscle growth in Asthma: proliferation, hypertrophy, and migration.
- Airway smooth muscle in Asthma.
- Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.
- Lung cells from neonates show a mesenchymal stem cell phenotype.
- Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.
- Regulation of airway smooth muscle alpha-actin expression by glucocorticoids.
- Rhinovirus infections: more than a common cold.
- Quercetin blocks airway epithelial cell chemokine expression.
- H. Influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression.
- Absence of typical unfolded protein response in primary cultured Cystic fibrosis airway epithelial cells.
- Transforming growth factor-beta induces airway smooth muscle hypertrophy.
- Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.
- 4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
- German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells.
- Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection.
- Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway.
- Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.
- Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe Asthma.
- p21Waf1/Cip1 and the prevention of oxidative stress.
- Pulmonary function in Bronchopulmonary dysplasia.
- Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells.
- Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulat...
- The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor.
- Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta.
- Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells.
- Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells.
- Regulation of human airway epithelial cell IL-8 expression by MAP kinases.
- Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
- ERK8, a new member of the mitogen-activated protein kinase family.
- In vivo hyperoxic exposure increases cultured Lung fibroblast proliferation and c-Ha-ras expression.
- Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway remodeling is mitogenic for airway smooth muscle.
- Structural and functional abnormalities of the airways of hyperoxia-exposed immature rats.
- Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway Disease.
- Recovery of airway structure and function after hyperoxic exposure in immature rats.
- Hyperoxia increases airway cell S-phase traversal in immature rats in vivo.
- Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.
- The effect of chloral hydrate on genioglossus and diaphragmatic activity.
- Pre-clinical medical student experience in a pediatric Pulmonary clinic.
- Rhinovirus-Induced Exacerbations of Asthma and COPD.
- Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.
- Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in Cystic fibrosis airway epithelial cells.
- Mitogenic signaling pathways in airway smooth muscle.
- Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
- Azithromycin increases survival and reduces lung inflammation in Cystic fibrosis mice.
- Ovalbumin sensitization and challenge increases the number of Lung cells possessing a mesenchymal stromal cell phenotype.
- Quercetin prevents progression of Disease in elastase/LPS-exposed mice by negatively regulating MMP expression.
- Burkholderia cenocepacia ET12 strain activates TNFR1 signalling in Cystic fibrosis airway epithelial cells.
- Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells.
- Proteases and Protease-activated receptors signalling: at the crossroads of acquired and innate immunity.
- Intracellular trafficking and replication of Burkholderia cenocepacia in human Cystic fibrosis airway epithelial cells.
- Yersinia YopJ inhibits pro-inflammatory molecule expression in human bronchial epithelial cells.
- German cockroach extract increases bronchial epithelial cell interleukin-8 expression.
- Mitogen-activated signaling and cell cycle regulation in airway smooth muscle.
- Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.
- Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction.
- Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells.
- Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway.
- p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.
- Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes.
Schools
University of Illinois At Chicago College of Medicine
Mc Gaw Mcnorthwestern University
Procedures Preformed
- Ventilation Management
Conditions Treated
- Acute Pharyngitis
- Asthma
- Atelectasis
- Bronchiectasis
- View All
Doctors Specialties
- Pediatric Critical Care Medicine
- Pediatric Pulmonology
Accepted Insurances
Awards
- Elected to Best Doctors in America
- Frederick G.L. Huetwell Professor of Pediatrics and Communicable Diseases
- Career Development Award
- Clinical Investigator Award
- Young Investigator Award
- Alpha Omega Alpha
Education
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Boston Children's Hospital -
University of Illinois College of Medicine -
University of Illinois
Hospital
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University of Michigan Hospitals and Health Centers
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