Professor, Pediatrics, University of Cincinnati College of Medicine
Allergy & Immunology
Dr. Marc E. Rothenberg, MD
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Doctor Marc E. Rothenberg, MD is an expert in the field of Allergy & Immunology. He went to Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He has 2 awards "Elected Member" and "Fellow (FAAAAI)". Marc Rothenberg is a published MD. He published 98 publications, including: 'Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monito...'
Publications
- Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for Eosinophilic oesophagitis.
- Newly developed and validated Eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monito...
- Eosinophils in mucosal immune responses.
- Resistin-like Molecule Alpha in Allergen-induced Pulmonary Vascular Remodeling.
- IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
- Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation.
- Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of Eosinophilic esophagitis.
- Genome-wide association analysis of Eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
- Analysis and expansion of the Eosinophilic esophagitis transcriptome by RNA sequencing.
- Genetic and Epigenetic Underpinnings of Eosinophilic Esophagitis.
- Utility of Neutrophil Fcγ Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease.
- Carbonic Anhydrase IV Is Expressed on IL-5-Activated Murine Eosinophils.
- Eosinophils and cancer.
- Demethylation of the Human Eotaxin-3 Gene Promoter Leads to the Elevated Expression of Eotaxin-3.
- Increased prevalence of Eosinophilic gastrointestinal disorders (EGID) in pediatric PTEN hamartoma tumor syndromes (PHTS).
- Molecular diagnosis of Eosinophilic esophagitis by gene expression profiling.
- Eosinophilic asthma: Insights into the effects of reducing IL-5 receptor-positive cell levels.
- Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in Eosinophilic esophagitis.
- Correlation of increased PARP14 and CCL26 expression in biopsies from children with Eosinophilic esophagitis.
- IL-33 Markedly Activates Murine Eosinophils by an NF-κB-Dependent Mechanism Differentially Dependent upon an IL-4-Driven Autoinflammatory Loop.
- PedsQL Eosinophilic esophagitis module: feasibility, reliability, and validity.
- Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.
- Emerging concepts of dietary therapy for pediatric and adult Eosinophilic esophagitis.
- High prevalence of Eosinophilic esophagitis in patients with inherited connective tissue disorders.
- Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
- Antigen presentation by eosinophils in Eosinophilic esophagitis?
- Advances in mechanisms of Allergy and clinical immunology in 2012.
- miR-223 Deficiency Increases Eosinophil Progenitor Proliferation.
- Long-term safety of mepolizumab for the treatment of hyperEosinophilic syndromes.
- Targeting eosinophils in Allergy, inflammation and beyond.
- ICON: Eosinophil Disorders.
- Working with the US Food and Drug Administration: Progress and timelines in understanding and treating patients with Eosinophilic esophagitis.
- Comparative dietary therapy effectiveness in remission of pediatric Eosinophilic esophagitis.
- MicroRNA signature in patients with Eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers.
- MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome.
- The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia.
- Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
- Reslizumab in children and adolescents with Eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial.
- Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders.
- IL-13 Receptor {alpha}1 Differentially Regulates Aeroallergen-Induced Lung Responses.
- MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-{gamma} Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity.
- Long-term outcomes in pediatric-onset esophageal eosinophilia.
- Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2.
- Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11.
- Genetic dissection of Eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies.
- Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-depen...
- Epigenetic Regulation of the IL-13-induced Human Eotaxin-3 Gene by CREB-binding Protein-mediated Histone 3 Acetylation.
- Eosinophilic esophagitis: Updated consensus recommendations for children and adults.
- The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice.
- Advances in mechanisms of Asthma, allergy, and immunology in 2010.
- Eosinophilic Esophagitis: Rapidly Advancing Insights.
- Differences in candidate gene association between European ancestry and African American Asthmatic children.
- A striking local esophageal cytokine expression profile in Eosinophilic esophagitis.
- TGF-β1: Mediator of a feedback loop in Eosinophilic esophagitis--or should we really say mastocytic esophagitis?
- IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation.
- Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders.
- Innate sensing of nickel.
- Indoor insect allergens are potent inducers of experimental Eosinophilic esophagitis in mice.
- Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.
- Involvement of mast cells in Eosinophilic esophagitis.
- Variants of thymic stromal lymphopoietin and its receptor associate with Eosinophilic esophagitis.
- IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.
- Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999.
- Refining the definition of hyperEosinophilic syndrome.
- Interleukin-15 expression is increased in human Eosinophilic esophagitis and mediates pathogenesis in mice.
- Organ-specific Eosinophilic disorders of the skin, lung, and gastrointestinal tract.
- Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
- IL-5 pathway inhibition in the treatment of Asthma and Churg-Strauss syndrome.
- Health-related quality of life across pediatric chronic conditions.
- Common variants at 5q22 associate with pediatric Eosinophilic esophagitis.
- Coordinate interaction between IL-13 and epithelial differentiation cluster genes in Eosinophilic esophagitis.
- Glucocorticoid-regulated genes in Eosinophilic esophagitis: a role for FKBP51.
- Importance of cytokines in murine allergic airway disease and human Asthma.
- Key advances in mechanisms of Asthma, allergy, and immunology in 2009.
- Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen.
- Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.
- HyperEosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
- Biology and treatment of Eosinophilic esophagitis.
- Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.
- Eosinophilic esophagitis: concepts, controversies, and evidence.
- MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression.
- Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation.
- Chemotactic factors associated with Eosinophilic gastrointestinal diseases.
- Dissociation between symptoms and histological severity in pediatric Eosinophilic esophagitis.
- Molecular diagnostics and treatment of patients with the hyperEosinophilic syndrome.
- Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea.
- Biology of the eosinophil.
- Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.
- Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.
- FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic Eosinophilic leukemia/hyperEosinophilic syndrome.
- Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
- Mitochondrial missile defense.
- 2007 E. Mead Johnson award: scientific pursuit of the Allergy problem.
- A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.
- Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.
- Clinical, pathologic, and molecular characterization of familial Eosinophilic esophagitis compared with sporadic cases.
- Surfactant protein D alters allergic lung responses in mice and human subjects.
Schools
Harvard Medical School
Children39s Hospital Boston
Conditions Treated
- Contact Dermatitis
- Eosinophilic Asthma
- Food Allergy
Doctors Specialties
- Pediatrics
- Allergy
- Immunology
Accepted Insurances
- Pathway X Tiered Hosp/Ind Direct Access OH
- Anthem Blue Cross Blue Shield HMO
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Cofinity PPO
- Coventry Health America PPO
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Preferred PPO
- Medical Mutual of Ohio POS
- Medicare MCR
- PHCS Network PPO
- Mutual of Omaha
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
- Fellow (FAAAAI)
Education
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Boston Children's Hospital -
Harvard Medical School
Hospital
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Cincinnati Children's Hospital Medical Center
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