Physician
Radiology
Dr. Margaret MacLean, MD
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Margaret MacLean, MD practices Radiology. She over the years received 2 awards: "Meaningful Use Stage 1 Certification" and "Top MD". Margaret MacLean, MD is also published. She has 95 publications published. The lastest publication: "Effect of novel mixed ETA/ETB antagonists on responses to ET-1 in human small muscular pulmonary arteries.'
Publications
- Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats.
- Role of phosphodiesterases in adult-onset pulmonary arterial hypertension.
- Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine.
- The role of alpha 2-adrenoceptors in the vasculature of the rat tail.
- Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles.
- Short-term haemodynamic effects of BQ-123, a selective endothelin ET(A)-receptor antagonist, in chronic heart failure.
- Endogenous nitric oxide modulates vasopressor responses, but not depressor responses, to spinal sympathetic nerve stimulation in pithed rats.
- Effect of artificial respiratory volume on the cardiovascular responses to an alpha 1- and an alpha 2-adrenoceptor agonist in the air-ventilated pithed rat.
- Effects of enalapril on changes in cardiac output and organ vascular resistances induced by alpha 1- and alpha 2-adrenoceptor agonists in pithed normotensive rats.
- Effect of spinal cord blockade on steady state ventilatory response to electrically induced exercise in anaesthetized dogs [proceedings].
- Effect of electrically induced exercise in anaesthetized dogs on ventilation and arterial pH [proceedings].
- Inhibitory regulation by co-released peptides of catecholamine secretion by the canine adrenal medulla.
- The role of oxygen in the visible-light inactivation of Staphylococcus aureus.
- Survival during exposure to the electrophilic reagent N-ethylmaleimide in Escherichia coli: role of KefB and KefC potassium channels.
- Thyroid function tests are rarely abnormal in patients with severe hyperemesis gravidarum.
- The ultrasonic assessment of discordant growth in twin pregnancies.
- Environmental decontamination of a hospital isolation room using high-intensity narrow-spectrum light.
- Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms.
- Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not ex...
- Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone.
- Cellular and molecular pathobiology of pulmonary arterial hypertension.
- The role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction.
- Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries.
- Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.
- Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.
- Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.
- The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension.
- Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
- Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties.
- Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension.
- An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pa...
- Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
- Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
- Serotonin and pulmonary hypertension--from bench to bedside?
- Cellular and molecular basis of pulmonary arterial hypertension.
- In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
- Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.
- The serotonin hypothesis of pulmonary hypertension revisited.
- The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension.
- Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH.
- Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.
- Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.
- Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension.
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.
- Pulmonary hypertension: therapeutic targets within the serotonin system.
- Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy.
- Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor...
- Contractile responses to human urotensin-II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat.
- 5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries.
- Effect of novel mixed ETA/ETB antagonists on responses to ET-1 in human small muscular pulmonary arteries.
- 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
- Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines.
- Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.
- 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.
- EndothelinB receptor-mediated contraction in human pulmonary resistance arteries.
- Pulmonary responses to 5-hydroxytryptamine and endothelin-1 in a rabbit model of left ventricular dysfunction.
- 5-HT moduline: an endogenous inhibitor of 5-HT(1B/1D)-mediated contraction in pulmonary arteries.
- Developmental changes in endothelium-dependent vasodilation and the influence of superoxide anions in perinatal rabbit pulmonary arteries.
- Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
- 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension.
- Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter.
- Endothelial ET(B) limits vascular remodelling and development of pulmonary hypertension during hypoxia.
- EndothelinB receptors in rabbit pulmonary resistance arteries: effect of left ventricular dysfunction.
- Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmona...
- Endothelin-1 has haemodynamic effects at pathophysiological concentrations in patients with left ventricular dysfunction.
- Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?
- Endothelin B receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction.
- Chronic exposure to hypoxia attenuates contractile responses in rat airways in vitro: a possible role for nitric oxide.
- 5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.
- Regional modulation of cyclic nucleotides by endothelin-1 in rat pulmonary arteries: direct activation of G(i)2-protein in the main pulmonary artery.
- The effect of chronic hypoxia on endothelin receptor subtype-mediated responses in rat isolated airways.
- Accumulation of nitrotyrosine correlates with endothelial NO synthase in pulmonary resistance arteries during chronic hypoxia in the rat.
- Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in the rat.
- Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: effect of chronic hypoxia.
- Endothelin-1: a mediator of pulmonary hypertension?
- Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth...
- Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries.
- Effects of endothelin-1 on isolated vascular beds from normotensive and spontaneously hypertensive rats.
- Heterogeneity of endothelin-B receptors in rabbit pulmonary resistance arteries.
- Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries.
- Pulmonary hypertension and the serotonin hypothesis: where are we now?
- EndothelinB receptor-mediated contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on endothelin responses in the rat.
- Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction.
- Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension?
- Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?
- Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship to tone and cyclic nucleotide levels.
- Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries.
- Influences of the endothelium and hypoxia on neurogenic transmission in the isolated pulmonary artery of the rabbit.
- Influences of the endothelium and hypoxia on alpha 1- and alpha 2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery.
- Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional intera...
- Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin-1 in the pithed rat.
- Effects of pre-contraction with endothelin-1 on alpha 2-adrenoceptor- and (endothelium-dependent) neuropeptide Y-mediated contractions in the isolated vascular bed of ...
- The influence of endothelin-1 on human foeto-placental blood vessels: a comparison with 5-hydroxytryptamine.
- Effect of neuropeptide Y on cardiac output, its distribution, regional blood flow and organ vascular resistances in the pithed rat.
Schools
University Of South Carolina School Of Medicine
Aberdeen Royal Infirm
Foresthill Health Center
Stanford University
Doctors Specialties
- Nuclear Medicine
- Radiology
Accepted Insurances
Awards
- Meaningful Use Stage 1 Certification
- Top MD
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