Professor, Medicine, UCSD School of Medicine
Gastroenterology
Dr. Mario M. Chojkier, MD
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Dr. Mario M. Chojkier works in the field of Gastroenterology. He received awards:"Elected Member". Mario Chojkier is also a published physician. He has 72 paper published. The most recent paper is: Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression.
Publications
- No Significant Effects of Ethyl-eicosapentanoic Acid on Histologic Features of Nonalcoholic SteatoHepatitis in a Phase 2 Trial.
- Novel inflammatory biomarkers of portal pressure in compensated cirrhotic patients.
- Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha.
- C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
- c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells.
- Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.
- Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression.
- TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region.
- Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity.
- A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic Hepatitis C.
- Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis.
- Regulation of liver-specific gene expression.
- Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133.
- Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia.
- Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants.
- Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain.
- Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.
- Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis?
- LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region.
- TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload.
- LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation.
- Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.
- Two different cis-acting regulatory regions direct cell-specific transcription of the collagen alpha 1(I) gene in hepatic stellate cells and in skin and tendon fibrobl...
- Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and nonalcoholic patients: localization and association with progression of liver fibrosis.
- Measurement of portal-Systemic shunting in the rat by using gamma-labeled microspheres.
- Esophageal tamponade in the treatment of bleeding varices. A decadel progress report.
- Bioluminescence assays for bile acids in the detection and follow-up of experimental liver injury.
- [3H]tryptophan-[14C]proline dual label method for the simultaneous determination of collagen and noncollagen protein production.
- Acetaldehyde stimulates collagen and noncollagen protein production by human fibroblasts.
- Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. In vitro studies in gu...
- New method for determining the extent of proline hydroxylation by measuring changes in the ratio of [4-3H]:[14C]proline in collagenase digests.
- Formation of proline metabolites in chick embryo bone: interference with the measurement of free hydroxyproline by ion-exchange chromatography.
- D-Galactosamine hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.
- A [4,5-3H]lysine:[14C]lysine dual-label method to measure lysine hydroxylation in collagen.
- Asymptomatic primary Biliary cirrhosis in an old man.
- Hepatocyte collagen production in vivo in normal rats.
- Hepatic collagen production in the rat is unaffected by methotrexate.
- Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.
- Predictors of outcome in massive upper gastroIntestinal hemorrhage.
- Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis.
- Therapeutic strategies for hepatic fibrosis.
- Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.
- Selective inhibition of collagen synthesis by the Ca2+ ionophore A23187 in cultured human fibroblasts.
- Different mechanisms decrease hepatic collagen and albumin production in fasted rats.
- Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?
- Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes.
- Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.
- Expression of collagen genes in the liver.
- Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia.
- LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.
- Cellular and molecular biology of hepatocyte growth, regeneration and gene expression.
- Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.
- d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.
- Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation.
- The acute-phase Response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-alpha.
- Contribution of hepatocytes and nonparenchymal cells to hepatic collagen production.
- Spontaneous meningococcal peritonitis: a report of two cases.
- A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from Esophageal varices.
- Inhibition of collagen synthesis in human episcleral fibroblasts by calcium ionophore a23187.
- [Portal Hypertension symposium dedicated to Dr Roberto Groszmann].
- A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatoHepatitis.
- C/EBP?-Thr217 phosphorylation signaling contributes to the development of lung injury and fibrosis in mice.
- A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis.
- C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells.
- C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin.
- Gastric adenocarcinoma inducing portal hypertension: a rare presentation.
- The effect of hepatic insufficiency on the safety and pharmacokinetics of paricalcitol (Zemplar).
- Inhibition of albumin synthesis in chronic Diseases: molecular mechanisms.
- Troglitazone and liver injury: in search of answers.
- Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids.
- Signal transduction in the liver: C/EBPbeta modulates cell proliferation and survival.
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Manometry
Conditions Treated
- Abdominal Pain
- Anemia
- Benign Neoplasm of the Digestive System
- Biliary Atresia
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Elected Member
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