Physician

Pediatrics

Dr. Mark A. Brockman, MD

Mark Brockman practices Pediatrics. He went to University of Louisville School of Medicine. University of Louisville School of Medicine has a rank of 83 in research and a 0 in primary care Mark Brockman is a published physician as well. He has 49 publications published. The latest was: Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs.

Publications

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.
Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1.
Impaired Nef function is associated with early control of HIV-1 viremia.
Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
The impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infe...
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers.
HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB.
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.
Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.
Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant.
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers.
Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes.
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotox...
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.
HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells.
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus ...
HIV increases HCV replication in a TGF-beta1-dependent manner.
Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells.
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophil...
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 repli...
Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection.
Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.
Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice.
Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity.
Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs.
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1.
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.
Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection.
Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.
Rapid ex vivo isolation and long-term culture of human Th17 cells.
Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection.
Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.
Humoral response to herpes simplex virus is complement-dependent.
Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR).
HIV infection increases HCV-induced hepatocyte apoptosis.
Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.

Schools

University of Louisville School of Medicine
University Of Louisville

Doctors Specialties

Pediatrics

Accepted Insurances

Education

University of Louisville
University of Louisville School of Medicine

Hospital

Kosair Children's Hospital

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