Professor of Medicine and Pediatrics, Director Laboratory of Mucosal Immunology and the Wm. K. Warren Medical Research Center for Celiac Disease
Gastroenterology
Dr. Martin F. Kagnoff, MD
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Martin F. Kagnoff, MD works in the field of Gastroenterology. He researched medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 7 awards "Fellow (AGAF)", "Rotschild Mayent Award", "Fiterman Senior Research Award", "Western Gastroenterology Research Prize", "Elected Member", "Research Career Development Award" and "Clinical Investigator Award". Dr. Martin F. Kagnoff has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.'
Publications
- IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
- Persistence of elevated deamidated gliadin peptide antibodies on a gluten-free diet indicates nonresponsive coeliac disease.
- Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes.
- GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa.
- Antibody repertoire profiling using bacterial display identifies reactivity signatures of celiac disease.
- TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival In Vivo.
- Introduction: celiac disease.
- The immunopathogenesis of celiac disease reveals possible therapies beyond the gluten-free diet.
- Constitutive intestinal NF-{kappa}B does not trigger destructive inflammation unless accompanied by MAPK activation.
- RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.
- GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.
- Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
- Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells.
- 2007 William K. Warren, Jr., prize for excellence in celiac disease research awarded to professor Ludvig M. Sollid of Oslo, Norway.
- Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1.
- Celiac disease: pathogenesis of a model immunogenetic disease.
- American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease.
- Microbial-epithelial cell crosstalk during inflammation: the host response.
- Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
- Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens.
- Overview and pathogenesis of celiac disease.
- Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
- Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells.
- Regulated production of the chemokine CCL28 in human colon epithelium.
- Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies.
- SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4.
- Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors.
- IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
- Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori.
- Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers.
- The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
- Celiac disease pathogenesis: the plot thickens.
- Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium.
- Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium.
- Central importance of immunoglobulin A in host defense against Giardia spp.
- Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines.
- D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling ...
- Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha pro...
- Current concepts in mucosal immunity. III. Ontogeny and function of gamma delta T cells in the intestine.
- Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1.
- Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells.
- Apoptosis of human intestinal epithelial cells after bacterial invasion.
- Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.
- Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription.
- Immune responses in human colon cancer. II. Cytotoxic antibody detected in patients'' sera.
- Effects of antigen-feeding on intestinal and systemic immune responses. III. Antigen-specific serum-mediated suppression of humoral antibody responses after antigen fe...
- IgA anti-dextran B1355 responses.
- Functional characteristics of Peyer''s patch lymphoid cells. IV. Effect of antigen feeding on the frequency of antigen-specific B cells.
- Effects of antigen-feeding on intestinal and systemic immune responses. I. priming of precursor cytotoxic T cells by antigen feeding.
- Effects of antigen-feeding on intestinal and systemic immune responses. II. Suppression of delayed-type hypersensitivity reactions.
- On the etiology of Crohn''s disease.
- Immune responses in human colon cancer. I. Microcytotoxicity assay for measuring killing of adherent human colon cancer cell lines.
- Is it ulcerative colitis or Crohn''s disease?
- Demonstration of organ differences in peripheral B cell populations through the use of deficient fetal bovine serum.
- Functional characteristics of Peyer''s patch cells. III. Carrier priming of T cells by antigen feeding.
- Antibody-dependent cell-mediated cytotoxicity. Comparative ability of murine Peyer''s patch and spleen cells to lyse lipopolysaccharide-coated and uncoated erythrocytes.
- Functional characteristics of intestinal Peyer''s patch lymphoid cells.
- Biochemical and morphological differentiation of the human colonic epithelial cell line SW620 in the presence of dimethylsulfoxide.
- Celiac disease. A gastrointestinal disease with environmental, genetic, and immunologic components.
- Cytokine-induced differentiation of IgA B cells: studies using an IgA expressing B-cell lymphoma.
- A tyrosine sulfated human glycoprotein with an unusual cell distribution.
- Detection of individual Peyer''s patch T cells that produce interleukin-5 and interferon-gamma.
- Molecular analysis of HLA DP and DQ genes associated with dermatitis herpetiformis.
- Detection by immunofluorescence of lymphokine-producing T cells.
- Effects of transforming growth factor beta-1 and interleukin-5 on IgA isotype switching at the clonal level.
- Expression of human immunodeficiency virus-1 in human colonic cells.
- Ulcerative colitis and T-cell receptor alpha-chain polymorphisms.
- HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines.
- Understanding the molecular basis of coeliac disease.
- Transforming growth factor beta 1 increases IgA isotype switching at the clonal level.
- Transforming growth factor-beta 1 is a costimulator for IgA production.
- Differential effect of interferon-gamma and interleukin-2 on the induction of IgA and IgM anti-dextran responses.
- A murine cytotoxic T lymphocyte clone from the intestinal mucosa that is antigen specific for proliferation and displays broadly reactive inducible cytotoxic activity.
- Spontaneous in vitro evolution of lytic specificity of cytotoxic T lymphocyte clones isolated from murine intestinal epithelium.
- Regulation of the anti-alpha (1,3) dextran response: two populations of dextran-reactive B cells that differ in their T cell requirements for induction to antibody syn...
- T dependent induction of an IgA and IgM anti-polysaccharide response.
- Production of murine leukemia virus in the immunodeficient wasted mutant mouse is associated with the wst allele.
- Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies.
- Celiac disease: adenovirus and alpha gliadin.
- Immunopathogenesis of celiac disease.
- Vicia villosa agglutinin separates freshly isolated Peyer's Patch T cells into interleukin 5- or interleukin 2-producing subsets.
- Development and characterisation of T lymphocyte lines from human small intestinal biopsies.
- Interleukin 5 is a differentiation factor for IgA B cells.
- Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype.
- Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.
- Identification of nuclear receptors for VIP on a human colonic adenocarcinoma cell line.
- An extended HLA-D region haplotype associated with celiac disease.
- Abnormalities in intestinal mucosal T cells in homosexual populations including those with the lymphadenopathy syndrome and acquired immunodeficiency syndrome.
- An HLA-D region restriction fragment length polymorphism associated with celiac disease.
- Rapid identification of hybridization probes for chromosomal walking.
- Abnormalities of the intestinal immune system in AIDS.
- Intestinal immunity and inflammation: recent progress.
- An 80 to 85 kilodalton human phosphoglycoprotein associated with cell activation.
- Phorbol myristate acetate induces IL-2 secretion by HUT 78 cells by a mechanism independent of protein kinase C translocation.
- Oral tolerance.
- Structural heterogeneity of human Pgp-1 and its relationship with p85.
- Immune-related intestinal Cl- secretion. I. Effect of histamine on the T84 cell line.
- Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.
- Immunologic mechanisms in intestinal diseases.
- Gastrointestinal manifestations of the acquired immunodeficiency syndrome.
Schools
Harvard Medical School
Peter B Brigham Hospital
New York Hospital
University Hospital
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
- Rotschild Mayent Award
- Fiterman Senior Research Award
- Western Gastroenterology Research Prize
- Elected Member
- Research Career Development Award
- Clinical Investigator Award
Education
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Boston University Medical Center -
New York Presbyterian Hospital - Cornell Campus -
Brigham and Women's Hospital -
Harvard Medical School
Hospital
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Rady Children's Hospital - San Diego -
Ronald Reagan UCLA Medical Center
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