CSO Lead Generation BioTherapeutics
Nephrology
Dr. Matthew Breyer, MD
|
|
Give Review
Doctor Matthew Breyer, MD works in the field of Nephrology. He went to Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School has a rank of 1 in research and a 12 in primary care Matthew Breyer is a published doctor. He has 101 papers published. The most current publication "COX2 selective NSAIDs and renal function: gain without pain?"
Publications
- A prospective study of multiple protein biomarkers to predict progression in diabetic chronic kidney disease.
- Improving productivity of modern-day drug discovery.
- Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells.
- Diabetic Nephropathy: A National Dialogue.
- Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice.
- Reduction of renal superoxide dismutase in progressive diabetic nephropathy.
- Mouse models of diabetic nephropathy.
- Better nephrology for mice--and man.
- Osteopontin in diabetic nephropathy: signpost or road?
- Sirt1 activation protects the mouse renal medulla from oxidative injury.
- A maladaptive role for EP4 receptors in podocytes.
- Progress in progression?
- Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1.
- EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.
- Translating experimental diabetic nephropathy studies from mice to men.
- Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta.
- Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.
- Urine concentrating defect in prostaglandin EP1-deficient mice.
- Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.
- Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract.
- Increased severity of renal impairment in nephritic mice lacking the EP1 receptor.
- A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
- Overexpression of cyclooxygenase-2 predisposes to podocyte injury.
- Expression of nestin in the podocytes of normal and diseased human kidneys.
- Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice.
- Physiologic and pathophysiologic roles of lipid mediators in the kidney.
- Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice.
- Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.
- Anti sense DNA down-regulates proteins kinase C-epsilon and enhances vasopressin-stimulated Na+ absorption in rabbit cortical collecting duct.
- 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis.
- Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
- Hormonal signaling and regulation of salt and water transport in the collecting duct.
- Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor.
- ATP-inhibitable Cl- channel in apical membranes of cultured rabbit cortical collecting duct cells.
- Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct.
- In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor.
- Evidence for basolateral membrane Ca2+/H+ exchange in outer medullary collecting duct.
- Volume and agonist-induced regulation of myosin light-chain phosphorylation in glomerular mesangial cells.
- Cloning and expression of the rabbit prostaglandin EP4 receptor.
- Functional and molecular aspects of renal prostaglandin receptors.
- Differential localization of prostaglandin E receptor subtypes in human kidney.
- Effect of vasopressin on intracellular Na+ concentration in cortical collecting duct.
- Intrarenal distribution of rabbit PKC zeta.
- cAMP-dependent protein kinase mediates hydrosmotic effect of vasopressin in collecting duct.
- Endothelin-1 receptor antagonist: effects on endothelin- and cyclosporine-treated mesangial cells.
- PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms.
- Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium.
- Muscarinic receptor activation inhibits AVP-induced water flow in rabbit cortical collecting ducts.
- Mechanism and regulation of proton transport in the outer medullary collecting duct.
- Cytosolic acidification stimulates a calcium influx that activates Na(+)-H+ exchange in LLC-PK1.
- Feedback inhibition of cyclic adenosine monophosphate-stimulated Na+ transport in the rabbit cortical collecting duct via Na(+)-dependent basolateral Ca++ entry.
- Triple signal transduction model for the mechanism of PGE2 actions in rabbit cortical collecting duct.
- Functional characterization of alpha- and beta-intercalated cell types in rabbit cortical collecting duct.
- Regulation of water and salt transport in collecting duct through calcium-dependent signaling mechanisms.
- PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation.
- Segmental distribution of epidermal growth factor binding sites in rabbit nephron.
- Cellular mechanisms of prostaglandin E2 and vasopressin interactions in the collecting duct.
- Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.
- Regulation of rabbit medullary collecting duct cell pH by basolateral Na+/H+ and Cl-/base exchange.
- Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.
- Characterization of the proton-secreting cell of the rabbit medullary collecting duct.
- Dose-dependent heterogenous actions of vasopressin in rabbit cortical collecting ducts.
- Phosphatidates inhibit vasopressin-induced water transport via protein kinase C activation.
- Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule.
- Mechanisms and regulation of renal H+ and HCO3- transport.
- Phorbol myristate acetate, dioctanoylglycerol, and phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule.
- Regulation of net bicarbonate transport in rabbit cortical collecting tubule by peritubular pH, carbon dioxide tension, and bicarbonate concentration.
- Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit collecting tubule.
- Effects of trifluoperazine, ouabain, and ethacrynic acid on intestinal calcium transport.
- Diphtheria immunity in Massachusetts--a study of three urban patient populations.
- Meningorectal fistula as a cause of polymicrobial anaerobic meningitis.
- Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule.
- Functional and molecular aspects of prostaglandin E receptors in the cortical collecting duct.
- Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct.
- Induction of rabbit cyclooxygenase 2 in the anterior uvea following glaucoma filtration surgery.
- Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans.
- Structure and localization of the rabbit prostaglandin EP3 receptor.
- Prostaglandin receptors in the kidney: a new route for intervention?
- Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor.
- Regulation of renal function by prostaglandin E receptors.
- Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor.
- COX2 selective NSAIDs and renal function: gain without pain?
- Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription.
- Type II cAMP-dependent protein kinase regulates electrogenic ion transport in rabbit collecting duct.
- Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney.
- Importance of the extracellular domain for prostaglandin EP(2) receptor function.
- Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival.
- Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development.
- Prostaglandin receptors: their role in regulating renal function.
- Characterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors.
- Structure-function analyses of eicosanoid receptors. Physiologic and therapeutic implications.
- Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas.
- Prostaglandin E receptors and the kidney.
- Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
- Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells.
- Cyclooxygenase-2 expression is associated with the renal macula densa of patients with Bartter-like syndrome.
- Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.
- G protein-coupled prostanoid receptors and the kidney.
- Cyclooxygenase 2 and the kidney.
- Prostanoid receptors: subtypes and signaling.
Schools
Harvard Medical School
Dallas Co Hp Parkland Mem
Michael Reese Hospital Med Center
Doctors Specialties
- Nephrology
Accepted Insurances
- GEHA
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- United Healthcare
Education
-
Harvard Medical School
Helpful Reviews
Similar Doctors
|
|
Dr. Thomas A. Golper, MD
 This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Kelly Birdwell, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Jeffrey L. Hymes, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Raymond C. Harris, MD |
|
|
Dr. Roy Zent, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Leslie S. Gewin, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Harry R. Jacobson, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. William W. Stead, MD
This Doctor is OpenDoctor Recommended.
This doctor has more publications
|
|
|
Dr. Orville C. Campbell, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Ghodrat Siami, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Chike M. Nzerve, MD |