Assistant Professor, Pathology, University of Iowa College of Medicine
Pathology
Dr. Matthew D. Krasowski, MD
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Matthew Krasowski is an expert in the field of Pathology. He went to medical school at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10/19 in Research/PrimaryCare. Matthew Krasowski is a published doctor. He published 79 publications, including: 'Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.' He accepts Medicare.
Publications
- Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.
- Promoting improved utilization of laboratory testing through changes in an electronic medical record: experience at an academic medical center.
- Use of a Rapid Ethylene Glycol Assay: a 4-Year Retrospective Study at an Academic Medical Center.
- N-acetylcysteine interference of Trinder-based assays.
- Patterns of Drugs and Drug Metabolites Observed in Meconium; What Do They Mean?
- Advances in anti-epileptic drug testing.
- Meconium Drug Testing in Multiple Births in the USA.
- A rapid analysis of plasma/serum ethylene and propylene glycol by headspace gas chromatography.
- Massive Ethylene Glycol Poisoning Triggers Osmotic Demyelination Syndrome.
- Detection of Neonatal Drug Exposure Using Umbilical Cord Tissue and Liquid Chromatography Time-of-Flight Mass Spectrometry.
- Cross-reactivity studies and predictive modeling of "Bath Salts" and other amphetamine-type stimulants with amphetamine screening immunoassays.
- Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay.
- Microbial biotransformations of bile acids as detected by electrospray mass spectrometry.
- Streamlined sign-out of capillary protein electrophoresis using middleware and an open-source macro application.
- Autoverification in a core clinical chemistry laboratory at an academic medical center.
- Using cheminformatics to predict cross reactivity of "designer drugs" to their currently available immunoassays.
- Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.
- Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.
- General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor ...
- Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
- Human dopamine transporter gene: coding region conservation among normal, Tourette''s disorder, alcohol dependence and attention-deficit hyperactivity disorder populat...
- Intravenous anesthetics differentially modulate ligand-gated ion channels.
- Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels.
- The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.
- General anaesthetic actions on ligand-gated ion channels.
- Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.
- Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.
- Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.
- A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice.
- Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.
- Alpha subunit isoform influences GABA(A) receptor modulation by propofol.
- Natural inhibitors of cholinesterases: implications for adverse drug reactions.
- Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
- A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps.
- Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants.
- Pathology consultation on vitamin D testing.
- A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs).
- Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.
- In silico repositioning of approved drugs for rare and neglected diseases.
- The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
- Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR.
- Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid.
- Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.
- Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites.
- Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.
- Clinical effects and toxicokinetic evaluation following massive topiramate ingestion.
- Educating medical students in laboratory medicine: a proposed curriculum.
- Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway.
- Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
- Bile salts of vertebrates: structural variation and possible evolutionary significance.
- Understanding nuclear receptors using computational methods.
- Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.
- Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine.
- Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays.
- Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays.
- The importance of discerning shape in molecular pharmacology.
- PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
- Intrinsic disorder in nuclear hormone receptors.
- Toxicology laboratory analysis and human exposure to p-chloroaniline.
- Machine learning methods and docking for predicting human pregnane X receptor activation.
- Molecular characterization of CYP2B6 substrates.
- Ligand specificity and evolution of liver X receptors.
- Evolution of pharmacologic specificity in the pregnane X receptor.
- Evolution of the bile salt nuclear receptor FXR in vertebrates.
- Functional evolution of the vitamin D and pregnane X receptors.
- Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphoru...
- Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
- Resident training in clinical chemistry.
- Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.
- Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
- Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography.
- Functional evolution of the pregnane X receptor.
- Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.
- Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons.
- Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).
- Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts.
- GPI-15715 Guilford.
- 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Education
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University of Chicago -
University of Chicago Pritzker School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1003880436 |
| Last Name Of The Provider | KRASOWSKI |
| First Name Of The Provider | MATTHEW |
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