Associate Professor, Internal Medicine, University of Utah School of Medicine
Internal Medicine
Dr. Matthew K. Topham, MD
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Matthew K. Topham, MD practices Internal Medicine. He attended University of Utah School of Medicine. He received 1 awards: "Elected Member". Dr. Matthew K. Topham is also a published doctor. He has 62 publication published. The most recent publication is: Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium.
- Diacylglycerol kinase ? modulates oncogenic properties of Lung cancer cells.
- Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc Min/+ mice.
- Regulation and Functions of Diacylglycerol Kinases.
- Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
- Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.
- Molecular species of phosphatidylinositol-cycle intermediates in the endoplasmic reticulum and plasma membrane.
- Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.
- Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
- The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.
- Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase.
- Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein.
- Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
- Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
- Role of the hydrophobic segment of diacylglycerol kinase epsilon.
- Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
- Measurement of mammalian diacylglycerol kinase activity in vitro and in cells.
- Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
- Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.
- Signaling roles of diacylglycerol kinases.
- The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.
- Regulation of neurite outgrowth in N1E-115 cells through PDZ-mediated recruitment of diacylglycerol kinase zeta.
- Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
- The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.
- Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol.
- Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins.
- Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta.
- Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling.
- Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.
- A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells.
- Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.
- Diacylglycerol kinases as sources of phosphatidic acid.
- Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.
- DGKι regulates presynaptic release during mGluR-dependent LTD.
- Endocannabinoids and diacylglycerol kinase activity.
- Study of arachidonoyl specificity in two enzymes of the PI cycle.
- Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells.
- Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
- Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.
- Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling.
- Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme.
- Membrane interactions of the hydrophobic segment of diacylglycerol kinase epsilon.
- Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.
- Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.
- Diacylglycerol kinases.
- Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine.
- Ceramide-induced alterations in dopamine transporter function.
- Diacylglycerol kinases: regulation and signaling roles.
- Inflammatory roles of P-selectin.
- Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.
- Alternative splicing of the human diacylglycerol kinase zeta gene in muscle.
- Bacterial lipopolysaccharide induces endothelial cells to synthesize a degranulating factor for neutrophils.
- Human endothelial cells regulate polymorphonuclear leukocyte degranulation.
- Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
- Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions.
- Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.
- Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling.
- Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.
- Physiological implications of the contrasting modulation of the activities of the epsilon- and zeta-isoforms of diacylglycerol kinase.
- cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7.
- Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial.
Schools
University of Utah
University Of Ut Med Center
Procedures Preformed
- Bronchoscopy
- Continuous Positive Airway Pressure (CPAP)
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Alkalosis
- Asthma
- Atelectasis
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Doctors Specialties
- Pulmonology
- Internal Medicine
Accepted Insurances
- Aetna
- Altius Health Plans
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- CoreSource
- First Health (Coventry Health Care) PPO
- Medicare MCR
- Heritage Signature
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Elected Member
Education
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University of Utah -
Duke University Hospital -
University of Utah School of Medicine
Hospital
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University of Utah Health Care - Hospital and Clinics
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1275613721 |
| Last Name Of The Provider | TOPHAM |
| First Name Of The Provider | MATTHEW |
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