Professor, University of Pennsylvania Perelman School of Medicine
Pediatric Pulmonology
Dr. Michael M. Grunstein, MD
Michael Grunstein is an expert in the field of Pediatric Pulmonology. He received 17 awards: "Invited Speaker: How Do Infammation and Infections Affect Airway Smooth Muscle Function", "Richard Farr Award - For outstanding contributions in the application of basic science to allergic diseases", "Invited Speaker: Mechanisms of induction of the proasthmatic phenotype in airway smooth muscle."", "Invited Speaker: Effect of Respiratory Infections on Airway Smooth Muscle Function", "Invited Speaker: "Autocrine Signaling in Airway Smooth Muscle"", "Chair and Invited Speaker: "New Concepts on the Pathogenesis of Asthma: State-of-the-Art"", "Invited Keynote Speaker: International Symposium on Asthma. "New Concepts on the Pathogenesis of Asthma"", "Invited Speaker: Transatlantic Airway Conference "Regulation of Second Messengers Associated with Airway Smooth Muscle Contraction and Relaxation"", "Member", "The Best Doctors in America", "Co-Director, Medical Program", "Elected Member", "Invited Keynote Speaker: "Regulation of Airway Smooth Muscle Responses: Signal Transduction and Second Messengers. State of the Art."", "Individual Fellowship Award", "Quebec Research Award", "Medical Scientist Fellowship Award" and "Dean's Honor List". Michael M. Grunstein is a published doctor and has 92 publications published. The lastest was: 'Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.'
Publications
- Current concepts on the use of glucocorticosteroids and beta-2-adrenoreceptor agonists to treat childhood asthma.
- Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.
- Variants of DENND1B associated with asthma in children.
- Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.
- Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function.
- ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry.
- Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.
- Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function.
- Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling.
- Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle.
- T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta.
- IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle.
- Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle.
- Autocrine regulation of airway smooth muscle responsiveness.
- Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness.
- Mechanism of cooperative effects of rhinovirus and atopic sensitization on airway responsiveness.
- Epigenetics in Saccharomyces cerevisiae.
- Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells.
- Methacholine-induced temporal changes in airway geometry and lung density by CT.
- Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness.
- Altered lung mechanics after double-lung transplantation.
- Regulation of second messengers associated with airway smooth muscle contraction and relaxation.
- Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.
- Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle.
- Rhinovirus-mediated changes in airway smooth muscle responsiveness: induced autocrine role of interleukin-1beta.
- Altered expression and action of the low-affinity IgE receptor FcepsilonRII (CD23) in asthmatic airway smooth muscle.
- Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle.
- Autocrine cytokine signaling mediates effects of rhinovirus on airway responsiveness.
- Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle.
- Maturational effect of enkephalin on respiratory control in newborn rabbits.
- Respiratory control during hypoxia in newborn rabbits: implied action of endorphins.
- Effects of hypoxia on respiratory control in neonates at high altitude.
- Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.
- cAMP generation inhibits inositol 1,4,5-trisphosphate binding in rabbit tracheal smooth muscle.
- Insulin-like growth factor axis in airway smooth muscle cells.
- Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis.
- Tachykinin regulation of airway smooth muscle cell proliferation.
- Mechanism of protein kinase C potentiation of airway beta-adrenergic relaxation.
- Effects of positive end-expiratory pressure on lung tissue mechanics in rabbits.
- Stimulation of lung surfactant secretion by endothelin-1 from rat alveolar type II cells.
- Assessment of methacholine-induced airway constriction by ultrafast high-resolution computed tomography.
- Role of muscarinic M2 receptors in regulating beta-adrenergic responsiveness in maturing rabbit airway smooth muscle.
- Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle.
- Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation.
- Corticosteroid modulation of Na(+)-K+ pump-mediated relaxation in maturing airway smooth muscle.
- Autocrine role of interleukin 1beta in altered responsiveness of atopic asthmatic sensitized airway smooth muscle.
- Autologously up-regulated Fc receptor expression and action in airway smooth muscle mediates its altered responsiveness in the atopic asthmatic sensitized state.
- Control of depth and frequency of breathing during baroreceptor stimulation in cats.
- Effect of SO2 on control of breathing in anesthetized cats.
- Analysis of interactions between central and vagal respiratory control mechanisms in cats.
- Drive and timing components of ventilation.
- Regulation of frequency and depth of breathing during expiratory threshold loading in cats.
- Assessment of signal transduction mechanisms regulating airway smooth muscle contractility.
- Maturation of inositol 1,4,5-trisphosphate receptor binding in rabbit tracheal smooth muscle.
- Opiate action in the pulmonary circulation.
- Role and mechanism of thromboxane-induced proliferation of cultured airway smooth muscle cells.
- Maturational regulation of inositol 1,4,5-trisphosphate metabolism in rabbit airway smooth muscle.
- Maturation of neuromodulatory effect of substance P in rabbit airways.
- Use of TAO without methylprednisolone in the treatment of severe asthma.
- Role of endothelin 1 in regulating rabbit airway contractility.
- Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle.
- Mechanisms of protein kinase C regulation of airway contractility.
- The effects of acute hypoxia and hypercapnia on pulmonary mechanics in normal subjects and patients with chronic pulmonary disease.
- Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells.
- Opposing hemodynamic effects of substance P on pulmonary vasculature in rabbits.
- Effect of substance P on neurally mediated contraction of rabbit airway smooth muscle.
- Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle.
- Vasoactive effects of substance P on isolated rabbit pulmonary artery.
- Effects of temperature on cholinergic contractility of rabbit airway muscle.
- Expiratory volume clamping: a new method to assess respiratory mechanics in sedated infants.
- Endogenous opioids modulate fetal rabbit lung maturation.
- Respiratory influence of peripheral chemoreceptor stimulation in maturing rabbits.
- Effects of impeded breathing on auditory brainstem responses in conscious man.
- Ontogeny of respiratory control and pulmonary mechanics in newborn rabbits.
- Effect of unilateral and bilateral vagotomy on the mechanical stability of ventilation in anesthetized cats.
- Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.
- Effect of body temperature on respiratory frequency in anesthetized cats.
- Control of tidal volume and respiratory frequency in anesthetized cats.
- Mechanisms of substance P-induced contraction of rabbit airway smooth muscle.
- Mechanism of substance P-induced bronchoconstriction in maturing rabbit.
- Effect of naloxone on ventilation in newborn rabbits.
- Comparison of responsiveness to methacholine, histamine, and exercise in subgroups of asthmatic children.
- Determinants of the slope of phase III of the single breath nitrogen test.
- Respiratory response to intraesophageal acid infusion in asthmatic children during Sleep.
- 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Amer...
- Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells.
- Pulmonary hypertension in children following extracorporeal membrane oxygenation therapy and repair of congenital diaphragmatic hernia.
- Albuterol protects against exercise-induced asthma longer than metaproterenol sulfate.
- Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle.
- Association between IL-1beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle.
- Rhinovirus elicits proasthmatic changes in airway responsiveness independently of viral infection.
Schools
McGill University Faculty of Medicine
University Colo School Med
University Calif
Conditions Treated
Doctors Specialties
Accepted Insurances
Awards
- Invited Speaker: “How Do Infammation and Infections Affect Airway Smooth Muscle Functionâ€Â
- Richard Farr Award - For outstanding contributions in the application of basic science to allergic diseases
- Invited Speaker: “Mechanisms of induction of the proasthmatic phenotype in airway smooth muscle."
- Invited Speaker: “Effect of Respiratory Infections on Airway Smooth Muscle Functionâ€Â
- Invited Speaker: "Autocrine Signaling in Airway Smooth Muscle"
- Chair and Invited Speaker: "New Concepts on the Pathogenesis of Asthma: State-of-the-Art"
- Invited Keynote Speaker: International Symposium on Asthma. "New Concepts on the Pathogenesis of Asthma"
- Invited Speaker: Transatlantic Airway Conference "Regulation of Second Messengers Associated with Airway Smooth Muscle Contraction and Relaxation"
- Member
- The Best Doctors in America
- Co-Director, Medical Program
- Elected Member
- Invited Keynote Speaker: "Regulation of Airway Smooth Muscle Responses: Signal Transduction and Second Messengers. State of the Art."
- Individual Fellowship Award
- Quebec Research Award
- Medical Scientist Fellowship Award
- Dean's Honor List
Education
-
University of Pennsylvania
-
University of Colorado
-
McGill University Faculty of Medicine
-
McGill University
Hospital
-
Hospital of the University of Pennsylvania
-
Pennsylvania Hospital
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