Professor, Medicine, Case Western Reserve University School of Medicine
Infectious Disease
Dr. Michael M. Lederman, MD
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Michael Lederman is an expert in the field of Infectious Disease. He went to Icahn School of Medicine at Mount Sinai. Icahn School of Medicine at Mount Sinai has a rank of 20 in research and a 62 in primary care Michael Lederman is a published doctor and has 102 publications published. The lastest was: 'Reply to Barrett, et al.'
Publications
- Prevention of SHIV transmission by topical IFN-β treatment.
- Repeated Cycles of Recombinant Human Interleukin-7 in HIV-Infected Patients with low CD4 T cell Reconstitution on Antiretroviral Therapy: Results of two Phase II Multi...
- Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes.
- Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses that are Transcriptionally Active Before Stopping Antiretroviral Therapy.
- Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
- Oxidized LDL levels are increased in HIV infection and may drive monocyte activation.
- Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among HIV-Infected Individuals.
- Rosuvastatin reduces vascular inflammation and T cell and monocyte activation in HIV-infected subjects on antiretroviral therapy.
- Influence of hepatitis C virus coinfection on CD4+ T cells of HIV-infected patients receiving HAART.
- Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non-AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment.
- Plasmacytoid Dendritic Cells Mediate Synergistic Effects of HIV and Lipopolysaccharide on CD27+ IgD- Memory B Cell Apoptosis.
- Relationship of HIV reservoir characteristics with immune status and viral rebound kinetics in an HIV therapeutic vaccine study.
- Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals.
- CD8 T cell persistence in treated HIV infection.
- Identification of Occult Fusobacterium nucleatum Central Nervous System Infection Using PCR Electrospray Ionization Mass Spectrometry (PCR/ESI-MS).
- HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increas...
- Coagulation and morbidity in treated HIV infection.
- Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 But Does Decrease Soluble Tissue Factor, LDL, and Oxidized LDL Levels in Untreated HIV Infection.
- Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.
- Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection.
- Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection.
- Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi.
- Low Proportions of CD28- CD8+ T cells Expressing CD57 Can Be Reversed by Early ART Initiation and Predict Mortality in Treated HIV Infection.
- Cycling memory CD4+ T cells in HIV disease have a diverse TCR repertoire and a phenotype consistent with bystander activation.
- Cytomegalovirus-specific responses of CD38+ memory T cells are skewed towards IFN-γ and dissociated from CD154 in HIV-1 infection.
- Rosuvastatin treatment reduces markers of monocyte activation in HIV infected subjects on antiretroviral therapy.
- Discordance between peripheral and colonic markers of inflammation during suppressive ART.
- Using glycosaminoglycan/chemokine interactions for the long-term delivery of 5P12-RANTES in HIV prevention.
- Response: maraviroc intensification and microbial translocation.
- Three Distinct Phases of HIV-1 RNA Decay in Treatment-Naive Patients Receiving Raltegravir-Based Antiretroviral Therapy: ACTG A5248.
- Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
- Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy.
- Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals.
- Older HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction.
- Circulating CD4+ and CD8+ T cells are activated in IBD and are associated with plasma markers of inflammation.
- The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized trial.
- Interleukin-7 promotes HIV persistence during antiretroviral therapy.
- Associations of T cell activation and inflammatory biomarkers with virological response to darunavir/ritonavir plus raltegravir therapy.
- Decreased IL-7 Responsiveness Is Related to Oxidative Stress in HIV Disease.
- Inadequate T follicular cell help impairs B cell immunity during HIV infection.
- Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections.
- Interferon-? Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers.
- Who would have thought?
- Impaired T cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
- Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity.
- Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression.
- Can immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus-infected patients?
- Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells.
- Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy.
- Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success.
- Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.
- A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults.
- Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.
- Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells.
- Resistance to the CCR5 Inhibitor 5P12-RANTES Requires a Difficult Evolution from CCR5 to CXCR4 Coreceptor Use.
- Dissociation of CD154 and cytokine expression patterns in CD38+ CD4+ memory T cells in chronic HIV-1 infection.
- Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5.
- Determinants of protection among HIVâexposed seronegative persons: an overview.
- Comparison of immunologic assays for detecting immune responses in HIV immunotherapeutic studies: AIDS Clinical Trials Group Trial A5181.
- Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
- Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral t...
- "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 d...
- Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.
- Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.
- Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients.
- Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred ART during an opportunistic infection.
- Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell funct...
- Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa.
- Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.
- Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge.
- Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.
- The effect of aging on T-regulatory cell frequency in HIV infection.
- Targeting a host element as a strategy to block HIV replication: is it nice to fool with Mother Nature?
- Chemokine analogues show suitable stability for development as microbicides.
- Hepatitis C virus-specific T-cell gamma interferon and proliferative responses are more common in perihepatic lymph nodes than in peripheral blood or liver.
- Pulmonary arterial hypertension and its association with HIV infection: an overview.
- Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection.
- Whither or wither microbicides?
- S-phase entry leads to cell death in circulating T cells from HIV-infected persons.
- Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients.
- Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis.
- CCR5 and its ligands: a new axis of evil?
- Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.
- Understanding the benign nature of SIV infection in natural hosts.
- Impaired induction of CD27 and CD28 predicts naive CD4 T cell proliferation defects in HIV disease.
- Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAART.
- Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
- TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection.
- Monitoring clinical trials of therapeutic vaccines in HIV infection: role of treatment interruption.
- Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, c...
- Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment.
- Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
- A plea for justice for jailed medical workers.
- Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection.
- Biology of CCR5 and its role in HIV infection and treatment.
- HIV coinfection impairs CD28-mediated costimulation of hepatitis C virus-specific CD8 cells.
- Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.
- HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.
- Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement.
- New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk.
- Reply to Barrett, et al.
Schools
Mount Sinai School Of Medicine Of New York University
University Hospital
Mt Sinai Hospital
University Hosps Cleveland
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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Mount Sinai School of Medicine -
Case Western Reserve University - University Hospitals -
Icahn School of Medicine at Mount Sinai
Hospital
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University Hospitals Case Medical Center
Drug Facts
| NPI NUMBER | 1437175098 | |
| NPPES Provider LastName | LEDERMAN | |
| NPPES Provider FirstName | MICHAEL | |
| NPPES Provider ZIPCode | 441061716 | |
| NPPES Provider State | OH | |
| Specialty Description | Infectious Disease | |
| Total Claim Count | 1106.0 | |
| Distinct Opioid Count | 1.0 | |
| Opioid Claim Count | 13.0 | |
| Percent Opioid Claims | 1.18 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1437175098 |
| Last Name Of The Provider | LEDERMAN |
| First Name Of The Provider | MICHAEL |
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