Physician

Pediatric Hematology & Oncology

Monica Bessler works in the field of Pediatric Hematology & Oncology. She received 2 awards: "Elected Member" and "Super Doctor". Monica M. Bessler is a published doctor as well. She has 49 publications published. The latest was: An in vitro model fails to demonstrate aerosolization of tumor cells. She accepts Medicare payments and is registered with Medicare.gov.

Publications

---

• An in vitro model fails to demonstrate aerosolization of tumor Cells.
• The genetics of dyskeratosis congenita.
• Recent insights into inherited bone marrow failure Syndromes.
• Clinical utility gene card for: dyskeratosis congenita.
• 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.
• Accelerated hematopoietic stem Cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment.
• Cytokinesis failure and attenuation: new findings in Fanconi Anemia.
• SnoRNA microarray analysis reveals changes in H/ACA and C/D RNA levels caused by dyskerin ablation in mouse liver.
• Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobi...
• Dyskerin ablation in mouse liver inhibits rRNA processing and Cell division.
• Acquired monosomy 7 Myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association.
• Anomalous electrophoretic migration of newly synthesized ribosomal RNAs and their precursors from Cells with DKC1 mutations.
• Cancer & inherited bone marrow failure states.
• Variable expression of Dkc1 mutations in mice.
• Dyskerin, telomerase and the DNA damage response.
• TINF2 mutations in children with severe aplastic Anemia.
• The pathophysiology of Disease in patients with paroxysmal nocturnal hemoglobinuria.
• TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.
• The role of human ribosomal proteins in the maturation of rRNA and ribosome production.
• Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference.
• Dark skin mutations shed light on inherited Anemia.
• A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice.
• Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
• Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene.
• Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.
• Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
• Dysfunctional telomeres and dyskeratosis congenita.
• Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production.
• A four base pair insertion in exon 1 of the RPS19 gene is a common polymorphism in African-Americans.
• Immunosuppressive therapy for acute porphyria: safety and efficacy in a patient with bone marrow failure.
• Low frequency of telomerase RNA mutations among children with aplastic Anemia or myelodysplastic syndrome.
• The effect of TERC haploinsufficiency on the inheritance of telomere length.
• Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
• Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.
• G-CSF induced progenitor mobilization in mice with PIGA- blood Cells.
• Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome.
• Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing.
• Association of Immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita.
• Dyskeratosis congenita and telomerase.
• ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement.
• A novel mechanism of complement-independent clearance of red Cells deficient in glycosyl phosphatidylinositol-linked proteins.
• Effect of proinflammatory cytokines on PIGA- hematopoiesis.
• Human telomerase RNA mutations and bone marrow failure.
• High-dose cyclophosphamide does not eradicate paroxysmal nocturnal haemoglobinuria haematopoiesis in mice carrying a Piga gene mutation.
• The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic Cells.
• Bone marrow failure in Shwachman-Diamond syndrome does not select for clonal haematopoiesis of the paroxysmal nocturnal haemoglobinuria phenotype.
• Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice.
• Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

Schools

---

• Universitat Zurich Medizinische Fakultat

Procedures Preformed

---

• Plasmapheresis

Conditions Treated

---

• Anemia
• Coagulation Disorders (incl. Hemophilia)
• Immune Thrombocytopenic Purpura (ITP)
• Leukocytosis
• View All

Doctors Specialties

---

• Hematology
• Pediatric Hematology
• Oncology

Accepted Insurances

---

Awards

---

• Elected Member
• Super Doctor

Hospital

---

• Hospital of the University of Pennsylvania

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Nick O. Onyemeke, MD
	Dr. Ivan P. Maillard, MD This Doctor is OpenDoctor Recommended.
	Dr. Carlyn R. Tan, MD
	Dr. Robert H. Wasserman, MD This Doctor is OpenDoctor Recommended.
	Dr. Maria T. Koehler, MD This Doctor is OpenDoctor Recommended.
	Dr. Julie W. Stern, MD This Doctor is OpenDoctor Recommended.
	Dr. Sujana Movva, MD This Doctor is OpenDoctor Recommended.
	Dr. David T. Teachey, MD This Doctor is OpenDoctor Recommended.
	Dr. Douglas B. Cines, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Frances M. Gill, MD This Doctor is OpenDoctor Recommended.
	Dr. Anjali Avadhani, MD This Doctor is OpenDoctor Recommended.
	Dr. Neal Flomenberg, MD This Doctor is OpenDoctor Recommended.
	Dr. Marcia Arem, MD This Doctor is OpenDoctor Recommended.
	Dr. Lewis J. Rose, MD This Doctor is OpenDoctor Recommended.
	Dr. Rebecca Citrin, MD This Doctor is OpenDoctor Recommended.

---

Doctor Directory | TOS | twitter | FB | Angel | blog