Professor, Medicine, Boston University School of Medicine
Endocrinology
Dr. Neil B. Ruderman, MD
|
|
Give Review
Neil Ruderman is an expert in the field of Endocrinology. He attended New York Medical College - Metropolitan Hospital Center. He has 2 awards "Elected Member" and "Super Doctor". Neil Ruderman is also a published physician. He has 57 paper published. The most recent paper is: Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.
Publications
- Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells.
- Increased Subcutaneous Adipose Tissue Expression of Genes Involved in GlyceroLipid-Fatty Acid Cycling in Obese Insulin-Resistant Versus -Sensitive Individuals.
- Insulin inhibits AMPK activity and phosphorylates AMPK Ser(485/491) through Akt in hepatocytes, myotubes and incubated rat skeletal muscle.
- AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
- Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.
- What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
- Protein kinase C-? contributes to impaired endothelial insulin signaling in humans with Diabetes mellitus.
- Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins.
- Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?
- Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.
- Acute Exercise Activates AMPK and eNOS in the Mouse Aorta.
- The evolution of insulin resistance in muscle of the glucose infused rat.
- Activation of AMP-Activated Protein Kinase (AMPK) Prevents Lipotoxicity in Retinal Pericytes.
- Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.
- AMPK and SIRT1: a long-standing partnership?
- Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 Diabetes mellitus and obesity.
- Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association With changes in cAMP, energy state, and endogenous fuel mobilization.
- Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.
- Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.
- Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells.
- AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.
- Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers.
- Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome.
- AMPK regulation of the growth of cultured human keratinocytes.
- Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.
- Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.
- Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.
- Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.
- Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.
- Why might thiazolidinediones increase exercise capacity in patients with type 2 Diabetes?
- AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats.
- Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes.
- Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.
- Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats.
- Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise.
- AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.
- AMP-activated protein kinase is required for the Lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.
- AMP-activated protein kinase activators can inhibit the growth of prostate Cancer cells by multiple mechanisms.
- AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.
- Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.
- Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways.
- Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.
- Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase.
- Insulin resistance in type 2 Diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.
- Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation.
- AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.
- Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues ...
- Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle.
- Exercise and insulin signaling: a historical perspective.
- Lipid-induced insulin resistance in human muscle is associated With changes in diacylglycerol, protein kinase C, and IkappaB-alpha.
- Hyperglycemia and insulin resistance: possible mechanisms.
- Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity.
- Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.
- Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism.
- AMPK activation: a therapeutic target for type 2 Diabetes?
Schools
University of Pittsburgh Main Campus
Michael Reese Hospital Il
Metropolitan Hospital Nyc
PresbyterianUniv Hospital Pa
Us Public Health Service Hospital
Peter Bent Brigham Joslin
Conditions Treated
- Acromegaly and Gigantism
- Diabetes Type 1
- Diabetes Type 2
- Diabetes With Renal Manifestations
- View All
Doctors Specialties
- Diabetes Medicine
- Endocrinology
Accepted Insurances
Awards
- Elected Member
- Super Doctor
Education
-
Brigham and Women's Hospital -
New York Medical College - Metropolitan Hospital Center -
University of Pittsburgh Medical Center -
University of Pittsburgh School of Medicine
Hospital
-
Boston Medical Center
Helpful Reviews
Similar Doctors
|
|
Dr. Caroline S. Fox, MD
 This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Frances J. Hayes, MD
This Doctor is OpenDoctor Recommended.
This doctor has more publications
|
|
|
Dr. Manuel G. Herrera-Acena, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert A. Gabbay, MD
This Doctor is OpenDoctor Recommended.
This doctor has more publications
|
|
|
Dr. Marvin S. Wool, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Alan P. Farwell, MD
This Doctor is OpenDoctor Recommended.
|