VA MEDICAL CENTER FTE STAFF PHYSICIAN

Pathology

Nils Lambrecht is an expert in the field of Pathology. He has 2 awards "Fellow" and "Best Ph.D. Thesis, Medical School". Nils W. Lambrecht has written publications. He has 36 publications published with PubMed. The lastest paper is: 'Structural aspects of the gastric H,K ATPase: the M5/M6 domain and alpha beta association.'

Publications

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• Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption.
• Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease.
• Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.
• HCA519/TPX2: a potential T-cell tumor-associated antigen for human hepatocellular carcinoma.
• Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.
• Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion.
• Fasting-induced changes in ECL cell gene expression.
• Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa.
• Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei.
• Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor.
• Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa.
• Prostaglandin E2 receptor subtype EP2- and EP4-regulated gene expression profiling in human ciliary smooth muscle cells.
• Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT.
• Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2.
• Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease.
• Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats.
• Ménétrier's disease of the stomach: a clinical challenge.
• Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice.
• The gastric H,K ATPase as a drug target: past, present, and future.
• PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells.
• Selective gene expression by rat gastric corpus epithelium.
• Effect of prostaglandins and capsaicin on gastric vascular flow and mucosal injury in endothelin-1-treated rats.
• Functional ablation of sensory neurons impairs healing of acute gastric mucosal damage in rats.
• Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin.
• Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat.
• Role of eicosanoids, nitric oxide, and afferent neurons in antacid induced protection in the rat stomach.
• Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach.
• Identification of the site of inhibition by omeprazole of a alpha-beta fusion protein of the H,K-ATPase using site-directed mutagenesis.
• Structural aspects of the gastric H,K ATPase: the M5/M6 domain and alpha beta association.
• Analysis of the membrane domain of the gastric H(+)/K(+)-ATPase.
• Comparison of covalent with reversible inhibitor binding sites of the gastric H,K-ATPase by site-directed mutagenesis.
• Effects of mutations in M4 of the gastric H+,K+-ATPase on inhibition kinetics of SCH28080.
• Review article: the control of gastric acid and Helicobacter pylori eradication.
• Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase.
• Tophaceous pseudogout: a pitfall in the diagnosis of chondrosarcoma.

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Awards

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• Fellow
• Best Ph.D. Thesis, Medical School

Education

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• UCLA Medical Center

Hospital

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• UC Irvine Medical Center

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