Lecturer in Medicine, Northwestern University Medical School
Gastroenterology
Dr. Paul K. Schlesinger, MD
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Paul Schlesinger works in the field of Gastroenterology. He studied medicine at University of Illinois College of Medicine. Doctor Paul K. Schlesinger, MD has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Trimethylaminuria: diet does not always control the fishy odor.'
Publications
- A role for peptides in overcoming endosomal entrapment in siRNA delivery - A focus on melittin.
- A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.
- Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers.
- Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling.
- Psychosine, the cytotoxic sphingolipid that accumulates in Globoid Cell Leukodystrophy, alters membrane architecture.
- Thrombin-Targeted Liposomes Establish a Sustained Localized Anticlotting Barrier against Acute Thrombosis.
- The structural basis of cholesterol accessibility in membranes.
- Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides.
- Programmable nanoparticle functionalization for in vivo targeting.
- Oxysterols are allosteric activators of the oncoprotein Smoothened.
- Interaction of Melittin Peptides with Perfluorocarbon Nanoemulsion Particles.
- Side-chain oxysterols: From cells to membranes to molecules.
- Calcium and bone Disease.
- High capacity Na+/H+ exchange activity in mineralizing osteoblasts.
- Cytolytic peptide nanoparticles ('NanoBees') for cancer therapy.
- 25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes.
- High capacity Na(+)/H(+) exchange activity in mineralizing osteoblasts.
- Characterization of perfluorooctylbromide-based nanoemulsion particles using atomistic molecular dynamics simulations.
- Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures.
- Detergent-activated BAX protein is a monomer.
- Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth.
- Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation.
- Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel.
- Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides.
- Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondria...
- The 2007 Gold Medal for Distinguished Service--Dr. Richard M. Smith.
- Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.
- The 2006 gold medal for distinguished service--Dr. René Rosas.
- c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.
- The 2005 Gold Medal for Distinguished Service--Dr. Robert Anderton.
- Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths.
- Anion Transport in Liposomes Responds to Variations in the Anchor Chains and the Fourth Amino Acid of Heptapeptide Ion Channels.
- The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid Bilayers.
- Synthetic ion channel activity documented by electrophysiological methods in living cells.
- In vitro differentiation of CD14 cells from osteopetrotic subjects: contrasting phenotypes with TCIRG1, CLCN7, and attachment defects.
- Synthetic hydraphile channels of appropriate length kill Escherichia coli.
- SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.
- Modifications of natural peptides for nanoparticle and drug design.
- [Effect of verapamil on the pressure response induced by cycloergometry in hypertensive patients].
- Iminopeptiduria, skin ulcerations, and edema in a boy with prolidase deficiency.
- Trimethylaminuria: diet does not always control the fishy odor.
- An expanded mechanism for rhodanese catalysis.
- Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.
- Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.
- Epidermal growth factor stimulates amiloride-sensitive 22Na+ uptake in A431 cells. Evidence for Na+/H+ exchange.
- Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.
- A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major.
- The 2004 Gold Medal for Distinguished Service--Dr. Frank Eggleston.
- Rat plasma clearance of horseradish peroxidase and yeast invertase is mediated by specific recognition.
- Different forms of rat beta-glucuronidase with rapid and slow clearance following intravenous injection: selective serum enhancement of slow clearance forms by organop...
- The Gold Medal for Distinguished Service--TDA's highest honor.
- Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.
- Clearance of lysosomal hydrolases following intravenous infusion. Kinetic and competition experiments with beta-glucuronidase and N-acetyl-beta-D-glucosaminidase.
- Cytoplasmic pH is regulated in isolated avian osteoclasts by a Cl-/HCO3- exchanger.
- Clearance of lysosomal hydrolases following intravenous infusion. The role of liver in the clearance of beta-glucuronidase and N-acetyl-beta-D-glucosaminidase.
- Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor r...
- Monensin inhibits recycling of macrophage mannose-glycoprotein receptors and ligand delivery to lysosomes.
- Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes.
- Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures.
- Evidence for specific recognition sites mediating clearance of lysosomal enzymes in vivo.
- Cholesterol effects on BAX pore activation.
- Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: apparent inhibition of receptor recycling.
- Nonesterified fatty acids induce transmembrane monovalent cation flux: host-guest interactions as determinants of fatty acid-induced ion transport.
- Expression and regulation of RAB3 proteins in osteoclasts and their precursors.
- Substrate recognition by osteoclast precursors induces C-src/microtubule association.
- Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.
- Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
- Calcium signalling and calcium transport in bone Disease.
- The Bax pore in liposomes, Biophysics.
- The specificity of chloroquine.
- Transient increase in intracellular pH during Dictyostelium differentiation.
- The M13 repeat probe detects RFLPs between two strains of the protozoan malaria parasite Plasmodium falciparum.
- Recognition of lysosomal glycosidases in vivo inhibitied by modified glycoproteins.
- Antimalarials increase vesicle pH in Plasmodium falciparum.
- Inoculum effect with chloroquine and Plasmodium falciparum.
- A perspective on antimalarial action: effects of weak bases on Plasmodium falciparum.
- Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
- Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum.
- Antimalarial agents: specific treatment regimens.
- Antimalarial agents: specific chemoprophylaxis regimens.
- Antimalarial agents: mechanism of chloroquine resistance.
- Antimalarial agents: mechanisms of action.
- Receptor-mediated uptake of a mannose-6-phosphate bearing glycoprotein by isolated chicken osteoclasts.
- Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.
- Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.
- Endocytosis and transcytosis by the capsule cell of vertebrate muscle spindles.
- Chloroquine and acid vesicle function.
- Phagosome-lysosome fusion in P388D1 macrophages infected with Histoplasma capsulatum.
- The cellular regulation of vesicle exocytosis by Entamoeba histolytica.
- The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH.
- Acid intracellular vesicles and the cytolysis of mammalian target cells by Entamoeba histolytica trophozoites.
- A rapid in vitro test for chloroquine-resistant Plasmodium falciparum.
- Accumulation of chloroquine by membrane preparations from Plasmodium falciparum.
- Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro.
- Calcium and the malaria parasite: parasite maturation and the loss of red cell deformability.
- Passive chloride permeability charge coupled to H(+)-ATPase of avian osteoclast ruffled membrane.
- Purification of a stilbene sensitive chloride channel and reconstitution of chloride conductivity into phospholipid vesicles.
- Physiologic rate of carrier-mediated Ca2+ entry matches active extrusion in human erythrocytes.
- Reversible inhibition of osteoclastic activity by bone-bound gallium (III).
- Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum.
Schools
University Of Illinois College Of Medicine Chicago
University Ill Hospital
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Diverticulosis, Intestinal
- Esophageal Varices
- Gastroesophageal Reflux Disease (GERD)
- View All
Doctors Specialties
- Gastroenterology
Accepted Insurances
Education
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University of Illinois College of Medicine
Hospital
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Jesse Brown Veterans Affairs Medical Center
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