Physician
Internal Medicine
Dr. Pedro M. Cuatrecasas, MD
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Pedro Cuatrecasas works in the field of Internal Medicine. He went to medical school at Washington University School of Medicine in St. Louis. He received awards:"Elected Member". Pedro M. Cuatrecasas is a published MD. He published 101 publications, including: 'Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin.'
Publications
- Protein kinase C and simulated ischemia possible aberrations of signal transduction during ischemia.
- MAMMALIAN GALACTOKINASE. DEVELOPMENTAL AND ADAPTIVE CHARACTERISTICS IN THE RAT LIVER.
- LACTASE DEFICIENCY IN THE ADULT. A COMMON OCCURRENCE.
- Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin.
- Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.
- Disulfide reduction converts the insulin receptor of human placenta to a low affinity form.
- Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.
- Digestion of insulin receptors with proteolytic and glycosidic enzymes-effects on purified and membrane-associated receptor subunits.
- Inhibition of 125I-chemotactic peptide uptake by protease inhibitors.
- Covalent affinity labeling of the formyl peptide chemotactic receptor.
- The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit.
- Role of extracellular arachidonate in regulation of prostaglandin biosynthesis in cultured 3T3 fibroblasts.
- Demonstration of choleragen-dependent ADP-ribosylation in whole cells and correlation with the activation of adenylate cyclase.
- Insulin receptor antibodies.
- Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.
- Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.
- Activation of pigeon erythrocyte adenylate cyclase by cholera toxin. Partial purification of an essential macromolecular factor from horse erythrocyte cytosol.
- Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum.
- Skeletal association of the cholera toxin receptor in rat erythrocytes.
- Evidence for cytoskeletal associations of the adenylate cyclase system obtained by differential extraction of rat erythrocyte ghosts.
- A monoclonal antibody to human insulin receptor.
- Effect of sodium molybdate on cytosolic estrogen receptor.
- Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.
- Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase.
- Exposure of cells to an acidic environment reverses the inhibition by methylamine of the mitogenic response to epidermal growth factor.
- Cytochalasins inhibit arachidonic acid metabolism in thrombin-stimulated platelets.
- Specific binding of solubilized adenylate cyclase to the erythrocyte cytoskeleton.
- Specific phospholipids are required to reconstitute adenylate cyclase solubilized from rat brain.
- A subpopulation of cultured human promyelocytic leukemia cells (HL-60) displays the formyl peptide chemotactic receptor.
- Insulin receptors and insulin receptor antibodies: structure-function relationships.
- The lipoxygenase product, 5-hydroperoxy-arachidonic acid, augments chemotactic peptide-stimulated arachidonic acid release from HL60 granulocytes.
- Chemotactic peptide stimulated endogenous arachidonic acid metabolism in HL-60 granulocytes.
- Lysophosphatidic acid potentiates the thrombin-induced production of arachidonate metabolites in platelets.
- Esterification of an endogenously synthesized lipoxygenase product into granulocyte cellular lipids.
- An overview of toxin-receptor interactions.
- The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.
- Rapid acylation and deacylation of arachidonic acid into phosphatidic acid of horse neutrophils.
- Thrombin and bradykinin modulate prostaglandin synthetase independently of phospholipase.
- Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.
- Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates.
- Contemporary drug development--dilemmas.
- Necrosin: purification and properties of a cytotoxin derived from a murine macrophage-like cell line.
- Genetic engineering and pharmaceuticals.
- Estimation of cell number by neutral red content. Applications for proliferative and survival assays.
- Ca2+/calmodulin-dependent protein kinases from the neuronal nuclear matrix and post-synaptic density are structurally related.
- Cytosolic activator of adenylate cyclase: Reconstitution, characterization, and mechanism of action.
- myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets.
- A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen.
- Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.
- Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.
- Visualization of enkephalin receptors by image-intensified fluorescence microscopy.
- Specificity of a phosphatase for phospholipid, Ca2+-dependent protein kinase-phosphorylated histone H1 resides in the catalytic subunit.
- A specific phosphoprotein phosphatase acts on histone H1 phosphorylated by protein kinase C.
- Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.
- Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.
- Insulin receptors.
- Developing concepts in receptor research.
- Monoclonal antibodies to receptors for insulin and somatomedin-C.
- Unmasking of magnesium-dependent high-affinity binding sites for [dAla2, dLeu5]enkephalin after pretreatment of brain membranes with guanine nucleotides.
- Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors.
- Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation.
- Epidermal growth factor: uptake and fate.
- Studies on the mechanism of enkephalin receptor down regulation.
- Analgesic activity of intracerebroventricular administration of morphiceptin and beta-casomorphins: correlation with the morphine (micro) receptor binding affinity.
- Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.
- Long-term epidermal growth factor-receptor internalization and processing in quiescent human fibroblasts.
- Properties of rat erythrocyte membrane cytoskeletal structures produced by digitonin extraction: digitonin-insoluble beta-adrenergic receptor, adenylate cyclase, and c...
- Molecular complexes involved in the regulation of adenylate cyclase.
- Heterogeneity and properties of opiate receptors.
- Novel opiate binding sites selective for benzomorphan drugs.
- Interactions of ligands with morphine and enkephalin receptors are differentially affected by guanine nucleotide.
- Insulin receptor: structure and function.
- Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors?
- Naloxazone irreversibly inhibits the high affinity binding of [125I]D-ala2-D-leu5-enkephalin.
- The phosphatidylinositol cycle and the regulation of arachidonic acid production.
- Peptide hormone-induced receptor mobility, aggregation, and internalization.
- Lysosomotropic amines inhibit mitogenesis induced by growth factors.
- The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL60 during dimethyl sulfoxide-induced differentiation.
- Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors.
- The production of 5-HETE and leukotriene B in rat neutrophils from carrageenan pleural exudates.
- Accumulation of epidermal growth factor within cells does not depend on receptor recycling.
- Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.
- Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes.
- Formyl peptide chemotactic receptors of leukocytes and macrophages.
- Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
- Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor.
- Cluster formation of opiate (enkephalin) receptors in neuroblastoma cells: differences between agonists and antagonists and possible relationships to biological functi...
- Protein kinase C: rapid enzyme purification and substrate-dependence of the diacylglycerol effect.
- Ca2+-calmodulin-dependent protein kinase in neuronal nuclei.
- Histones H3 and H4 inhibit protein kinase C specifically.
- Inhibition of epidermal growth factor-induced mitogenesis by amiloride and an analog: evidence against a requirement for Na+/H+ exchange.
- Interferon-mediated changes in lipid metabolism.
- Formation and identification of cytoskeletal components from liver cytosolic precursors.
- Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor crosslinking.
- Establishment of the interferon-mediated antiviral state: possible role of superoxide dismutase.
- Changes in fatty acyl chains of phospholipids induced by interferon in mouse sarcoma S-180 cells.
- Interferon-resistant cell line lacks fatty acid cyclooxygenase activity.
- Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.
- Hormone receptors, membrane phospholipids, and protein kinases.
- Benzomorphan sites are ligand recognition sites of putative epsilon-receptors.
Schools
Washington Center School of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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Washington University School of Medicine in St. Louis
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