Professor of Biological Chemistry
Hematology
Dr. Peter C. Agre, MD
Peter Agre is an expert in the field of Hematology. He received 2 awards: "Elected Member" and "Whos Who in Medicine and Healthcare". Peter Agre is a published doctor and has 101 publications published. The lastest was: 'Functional analyses of aquaporin water channel proteins.'
Publications
- Foreword to 2014 aquaporins special issue.
- Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection.
- Protective role of brain water channel AQP4 in murine cerebral malaria.
- Advancing science, promoting peace.
- Using ethics to fight bioterrorism.
- Functional requirement of aquaporin-5 in plasma membranes of sweat glands.
- Organ-Specific Splice Variants of Aquaporin Water Channel AgAQP1 in the Malaria Vector Anopheles gambiae.
- Deficient red-cell spectrin in severe, recessively inherited spherocytosis.
- Partial deficiency of erythrocyte spectrin in hereditary spherocytosis.
- Action at a distance: another lesson from the red cell.
- Biochemistry and molecular genetics of Rh antigens.
- Mutant forms of spectrin alpha-subunits in hereditary elliptocytosis.
- Differential control of band 3 lateral and rotational mobility in intact red cells.
- Cultured bovine corneal endothelial cells express CHIP28 water channels.
- Clinical disorders of the erythrocyte membrane skeleton.
- A new face of the Rhesus antigen.
- Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.
- Clinical relevance of basic research on red cell membranes.
- Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes.
- Aquaporins: a family of water channel proteins.
- Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis.
- Expression of multiple water channel activities in Xenopus oocytes injected with mRNA from rat kidney.
- Biochemistry of the erythrocyte Rh polypeptides: a review.
- Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP.
- The red cell membrane skeleton: a model with general biological relevance but pathological significance for blood.
- Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin.
- Molecular genetics of the human beta-spectrin gene.
- Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance.
- Decreased membrane mechanical stability and in vivo loss of surface area reflect spectrin deficiencies in hereditary spherocytosis.
- Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes.
- Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.
- The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein.
- Isolation of proteins related to the Rh polypeptides from nonhuman erythrocytes.
- Distinct variants of erythrocyte protein 4.1 inherited in linkage with elliptocytosis and Rh type in three white families.
- Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes.
- Molecular biology of the Rh antigens.
- Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat.
- Aquaporins: water channel proteins of plant and animal cells.
- Reconstitution of water channel function of aquaporins 1 and 2 by expression in yeast secretory vesicles.
- Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye.
- Respiratory aquaporins in lung inflammation: the night is young.
- A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin.
- Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
- Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen.
- Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.
- Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex.
- Sequence and exon-intron organization of the DNA encoding the alpha I domain of human spectrin. Application to the study of mutations causing hereditary elliptocytosis.
- Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy.
- Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes.
- Membrane dynamics of the water transport protein aquaporin-1 in intact human red cells.
- Projection map of aquaporin-1 determined by electron crystallography.
- Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum.
- Amino-acid substitution in alpha-spectrin commonly coinherited with nondominant hereditary spherocytosis.
- Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome.
- Homer W. Smith award lecture. Aquaporin water channels in kidney.
- Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: a Fourier transform infrared spectroscopy study of two-dimensional membrane crystals.
- Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes.
- ABH and Colton blood group antigens on aquaporin-1, the human red cell water channel protein.
- Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjögren's syndrome patients.
- Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction.
- Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
- The aquaporins, blueprints for cellular plumbing systems.
- The mouse aquaporin-1 gene.
- Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
- Functional impairment of lens aquaporin in two families with dominantly inherited cataracts.
- Functional analyses of aquaporin water channel proteins.
- Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia.
- The structure of aquaporin-1 at 4.5-A resolution reveals short alpha-helices in the center of the monomer.
- Man Is not a rodent: aquaporins in the airways.
- Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta.
- Aquaporins and ion conductance.
- Hourglass pore-forming domains restrict aquaporin-1 tetramer assembly.
- Aquaporin in Candida: characterization of a functional water channel protein.
- Aquaporins in health and disease.
- Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat.
- Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements.
- Adenovirus-mediated expression of aquaporin-5 in epithelial cells.
- Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. I. Biochemical identification of rearrangements in the spectrin/actin binding doma...
- Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular ...
- Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.
- Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands.
- The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization.
- Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells.
- Developmental gene expression and tissue distribution of the CHIP28 water-channel protein.
- The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
- Human red cell Aquaporin CHIP. II. Expression during normal fetal development and in a novel form of congenital dyserythropoietic anemia.
- Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5.
- Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.
- The 3.7 A projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer.
- Aquaporin water channels: unanswered questions and unresolved controversies.
- Aquaporin null phenotypes: the importance of classical physiology.
- The three-dimensional structure of human erythrocyte aquaporin CHIP.
- Expression of aquaporin isoforms during human and mouse tooth development.
- Regulation of the Escherichia coli water channel gene aqpZ.
- CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.
- Taurine and water channels are co-localized in renal tubule cells and other tissues. Immunocytochemical studies in rats.
- Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.
- Water and ion permeation of aquaporin-1 in planar lipid bilayers. Major differences in structural determinants and stoichiometry.
- Aquaporin-1 water channel expression in human kidney.
- Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Internal Medicine
- Hematology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Hospital
-
Johns Hopkins Hospital
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