Professor of Medicine
Internal Medicine
Dr. Ralph A. Giannella, MD
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Ralph A. Giannella practices Internal Medicine. He went to medical school at Albany Medical College. He has 6 awards "CMS Meaningful Use Stage 1 Certification", "Best Physicians in America", "Top 75 Gastroenterologists in America", "Top 25 physicians in Ohio", "Fellow (AGAF)" and "Elected Member". Ralph A. Giannella, MD is also published. He has 101 publications published. The lastest publication: "Validation of a volunteer model of cholera with frozen bacteria as the challenge.' He accepts all Medicare patients.
Publications
- Infectious colitis.
- Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intes...
- Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.
- Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea.
- Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
- E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions.
- Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccine.
- Pathogenesis of salmonellosis. Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum.
- Acute bacterial diarrhea.
- Mechanisms of Shigella pathogenesis.
- Cholera-like diarrhoea in salmonellosis.
- Effect of Strongyloides ratti on small bowel function in normal and immunosuppressed host rats.
- A hospital food-borne outbreak of diarrhea caused by Bacillus cereus: clinical, epidemiologic, and microbiologic studies.
- Antibiotic therapy for bacterial enterocolitis: a comprehensive review.
- Diarrhea caused by adherent enteropathogenic E. coli.
- Antibiotic-associated diarrhea and Clostridium difficile colitis: an update.
- Importance of the Intestinal inflammatory reaction in salmonella-mediated Intestinal secretion.
- Effect of indomethacin on Intestinal water transport in salmonella-infected rhesus monkeys.
- Small Intestinal mucosal injury in the experimental blind loop syndrome. Light- and electron-microscopic and histochemical studies.
- Pathophysiology of Shigella diarrhea in the rhesus monkey: Intestinal transport, morphological, and bacteriological studies.
- Effect of clindamycin on Intestinal water and glucose transport in the rat.
- Passing the torch: a look back at our editorship.
- Competition between bacteria and intrinsic factor for vitamin B 12 : implications for vitamin B 12 malabsorption in Intestinal bacterial overgrowth.
- Jejunal brush border injury and impaired sugar and amino acid uptake in the blind loop Syndrome.
- Practical management of acute diarrhea.
- Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastroIntestinal symptoms.
- Salmonella Enteritis. II. Fulminant diarrhea in and effects on the small intestine.
- Salmonella Enteritis. I. Role of reduced gastric secretion in pathogenesis.
- Preparation of stable 125I cyclic GMP tyrosine methyl ester suitable for 3',5' cyclic GMP radioimmunoassay by HPLC.
- Approach to the adult patient with acute diarrhea.
- Helicobacter pylori: an update for primary care physicians.
- Acute diarrhea: a practical review.
- Effect of short-chain fatty acids on cyclic 3',5'-guanosine monophosphate-mediated colonic secretion.
- The role of altered Intestinal permeability in the pathogenesis of salmonella diarrhea in the rhesus monkey.
- Pathogenesis of Salmonella-mediated Intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin.
- Role of plasma filtration in the Intestinal fluid secretion mediated by infection with Salmonella typhimurium.
- Use of omeprazole in the management of giant Duodenal ulcer: results of a prospective study.
- Misdiagnosis of the Zollinger-Ellison Syndrome due to hyperlipidemia.
- Pathophysiology of Salmonella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies.
- Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a.
- Pediatric gastroenterology and the AGA.
- Activation of Intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin.
- Enteric infections: 50 years of progress.
- Na(+)-K(+)-ATPase gene expression in rat intestine and Caco-2 cells: response to thyroid hormone.
- Amino acid sequence of heat-stable enterotoxin produced by Escherichia coli pathogenic for man.
- Escherichia coli heat-stable enterotoxin: biochemical and physiological effects on the intestine.
- Escherichia coli heat-stable toxin: its effect on motility of the small intestine.
- Simple and reliable enzyme-linked immunosorbent assay with monoclonal antibodies for detection of Escherichia coli heat-stable enterotoxins.
- Activation of guanylate cyclase by E. coli heat-stable enterotoxin (STa). Modulation by NAD and pertussis toxin.
- Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man.
- Monoclonal antibodies to Escherichia coli heat-stable enterotoxin.
- Biological and immunological characteristics of 125I-4Tyr and -18Tyr Escherichia coli heat-stable enterotoxin species purified by high-performance liquid chromatography.
- Blinded, two-laboratory comparative analysis of Escherichia coli heat-stable enterotoxin production by using monoclonal antibody enzyme-linked immunosorbent assay, rad...
- Binding of Escherichia coli heat-stable enterotoxin to receptors on rat Intestinal cells.
- A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants.
- Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines.
- Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea.
- Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf.
- Comparison of the biological actions of three purified heat-stable enterotoxins: effects on ion transport and guanylate cyclase activity in rabbit ileum in vitro.
- Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line.
- Revised amino acid sequence for a heat-stable enterotoxin produced by an Escherichia coli strain (18D) that is pathogenic for humans.
- Immunization of swine with heat-stable Escherichia coli enterotoxin coupled to a carrier protein does not protect suckling pigs against an Escherichia coli strain that...
- Development of a radioimmunoassay for Escherichia coli heat-stable enterotoxin: comparison with the suckling mouse bioassay.
- Awareness about clostridium difficile infection among internal medicine residents in the United States.
- Hemorrhagic colitis associated with Escherichia coli O157:H7.
- Suckling mouse model for detection of heat-stable Escherichia coli enterotoxin: characteristics of the model.
- Effect of purified Escherichia coli heat-stable enterotoxin on Intestinal cyclic nucleotide metabolism and fluid secretion.
- Validation of a volunteer model of cholera with frozen bacteria as the challenge.
- Protein kinase C regulates transcription of the human guanylate cyclase C gene.
- Different crosslinking agents identify distinctly different putative Escherichia coli heat-stable enterotoxin rat Intestinal cell receptor proteins.
- Renal effects of uroguanylin and guanylin in vivo.
- Production of neutralizing monoclonal antibodies to Escherichia coli heat-stable enterotoxin.
- Escherichia coli heat-stable enterotoxins, guanylins, and their receptors: what are they and what do they do?
- Binding of E. coli heat-stable enterotoxin to rat Intestinal brush borders and to basolateral membranes.
- T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin.
- Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice.
- Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139.
- Small and large Intestinal guanylate cyclase activity in children: effect of age and stimulation by Escherichia coli heat-stable enterotoxin.
- Differences in jejunal and ileal response to E. coli enterotoxin: possible mechanisms.
- Jejunal toxin inactivation regulates susceptibility of the immature rat to STa.
- Hepatocyte nuclear factor-4 regulates Intestinal expression of the guanylin/heat-stable toxin receptor.
- The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin.
- Association and dissociation of Escherichia coli heat-stable enterotoxin from rat brush border membrane receptors.
- Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells.
- Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12.
- Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera follo...
- Colonocyte basolateral membranes contain Escherichia coli heat-stable enterotoxin receptors.
- A role for guanylate cyclase C in acid-stimulated Duodenal mucosal bicarbonate secretion.
- Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced Intestinal secretion.
- The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine.
- Receptors for Escherichia coli heat stable enterotoxin in human intestine and in a human Intestinal cell line (Caco-2).
- A gradient in expression of the Escherichia coli heat-stable enterotoxin receptor exists along the villus-to-crypt axis of rat small intestine.
- Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat.
- Citrobacter freundii produces an 18-amino-acid heat-stable enterotoxin identical to the 18-amino-acid Escherichia coli heat-stable enterotoxin (ST Ia).
- Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children.
- Escherichia coli enterotoxin (STa) binds to receptors, stimulates guanyl cyclase, and impairs absorption in rat colon.
- Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent.
- Thinking beyond the colon-small bowel involvement in clostridium difficile infection.
- Mechanisms of infectious diarrhea.
- AGA PAC: an essential tool to advance gastroenterology.
Schools
Albany Medical College
Boston City Hospital
Boston Va Hospital
Thordike Meml Boston City H
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
- Fecal Impaction Removal
- Liver Biopsy
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Conditions Treated
- Abdominal Pain
- Anemia
- Barrett's Esophagus
- Benign Neoplasm of the Digestive System
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Doctors Specialties
- Gastroenterology
- Internal Medicine
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Best Physicians in America
- Top 75 Gastroenterologists in America
- Top 25 physicians in Ohio
- Fellow (AGAF)
- Elected Member
Education
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Boston University Medical Center -
Albany Medical College
Hospital
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University of Cincinnati Medical Center
Drug Facts
| NPI NUMBER | 1073579892 | |
| NPPES Provider LastName | GIANNELLA | |
| NPPES Provider FirstName | RALPH | |
| NPPES Provider ZIPCode | 452194231 | |
| NPPES Provider State | OH | |
| Specialty Description | Gastroenterology | |
| Total Claim Count | 259.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1073579892 |
| Last Name Of The Provider | GIANNELLA |
| First Name Of The Provider | RALPH |
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