Professor, Pathology, University of Alabama School of Medicine
Pathology
Dr. Ralph P. Bucy, MD
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Ralph P. Bucy is an expert in the field of Pathology. Ralph Bucy is a published MD. He has 97 papers published. The most current publication "Heterogeneity in the clonal T cell response. Implications for models of T cell activation and cytokine phenotype development."
Publications
- Enhanced autoantibody production and Mott cell formation in FcμR-deficient autoimmune mice.
- The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity.
- Comparison of immunologic assays for detecting immune responses in HIV immunotherapeutic studies: AIDS Clinical Trials Group Trial A5181.
- Targeting MHC class I monomers to dendritic cells inhibits the indirect pathway of allorecognition and the production of IgG alloantibodies leading to long-term allogr...
- A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy.
- Preferential priming of alloreactive T cells with indirect reactivity.
- Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.
- CD8+ suppressor T cells resurrected.
- Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline.
- Effect of highly active antiretroviral therapy on viral burden in the lungs of HIV-infected subjects.
- Antigen, in the presence of TGF-beta, induces up-regulation of FoxP3gfp+ in CD4+ TCR transgenic T cells that mediate linked suppression of CD8+ T cell responses.
- The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus ...
- A randomized, partially blinded phase 2 trial of antiretroviral therapy, HIV-specific immunizations, and interleukin-2 cycles to promote efficient control of viral rep...
- TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection.
- Enhanced responsiveness to antigen contributes more to immunological memory in CD4 T cells than increases in the number of cells.
- Intratumoral administration of a recombinant canarypox virus expressing interleukin 12 in patients with metastatic melanoma.
- Evidence for cooperativity in the rejection of cardiac grafts mediated by CD4 TCR Tg T cells specific for a defined allopeptide.
- Activation and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft rejection.
- Viral and cellular dynamics in HIV disease.
- CD4+ T-cell receptor transgenic T cells alone can reject vascularized heart transplants through the indirect pathway of alloantigen recognition.
- Addition of cyclophosphamide to antiretroviral therapy does not diminish the cellular reservoir in HIV-infected persons.
- Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway.
- Immune function in patients with rheumatoid arthritis treated with etanercept.
- Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease.
- Quantitation of HIV-1 by real-time PCR with a unique fluorogenic probe.
- Perspectives on inducing efficient immune control of HIV-1 replication--a new goal for HIV therapeutics?
- Heterogeneity of T cell clones specific for a single indirect alloantigenic epitope (I-Ab/H-2Kd54-68) that mediate transplant rejection.
- Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: A case report.
- Stability in the HIV vDNA pool in peripheral CD4+ T cells of untreated patients by single tube quantitative PCR.
- Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
- Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy.
- The Arthus reaction in rodents: species-specific requirement of complement.
- Evaluation of distinct blood lymphocyte populations in human immunodeficiency virus type 1-infected subjects in the absence or presence of effective therapy.
- Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector.
- Correlation between circulating stromal cell-derived factor 1 levels and CD4+ cell count in human immunodeficiency virus type 1-infected individuals.
- The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin.
- Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA.
- Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues.
- Immune clearance of HIV type 1 replication-active cells: a model of two patterns of steady state HIV infection.
- Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis.
- Heterogeneity in the clonal T cell response. Implications for models of T cell activation and cytokine phenotype development.
- Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontitis.
- Effects of tapering doses of oral prednisone on viral load among HIV-infected patients with unexplained weight loss.
- The effect of rhGH in vitro on donor-specific hyporesponsiveness in pediatric transplantation.
- Single-cell analyses of CD4+ T cells from alpha beta T cell receptor-transgenic mice: a distinct mucosal cytokine phenotype in the absence of transgene-specific antigen.
- Immunosuppression by inhibition of cellular adhesion mediated by leukocyte function-associated antigen-1/intercellular adhesion molecule-1 in murine cardiac transplant...
- Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene the...
- Visualization of antigen-specific T cell activation and cytokine expression in vivo.
- Growth hormone induces interferon gamma production and may play a role in the presentation of alloantigens in vitro.
- The effect of recombinant human growth hormone on responses to alloantigens in the pediatric transplant patient.
- Gamma delta T cells are secondary participants in acute graft-versus-host reactions initiated by CD4+ alpha beta T cells.
- Simultaneous quantitation of multiple cytokine mRNAs by RT-PCR utilizing plate based EIA methodology.
- Phase II trial of murine monoclonal antibody D612 combined with recombinant human monocyte colony-stimulating factor (rhM-CSF) in patients with metastatic gastrointest...
- Interleukin-2 diphtheria fusion protein (DAB486IL-2) in refractory rheumatoid arthritis. A double-blind, placebo-controlled trial with open-label extension.
- Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.
- Germinal center T cells exhibit properties of memory helper T cells.
- Regeneration of T cells after chemotherapy.
- Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and a...
- In situ hybridization for cytokine mRNA with digoxigenin-labeled riboprobes. Sensitivity of detection and double label applications.
- In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts.
- Infiltration of CD4+ T cells into cornea during development of Onchocerca volvulus-induced experimental sclerosing keratitis in mice.
- Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.
- Heterogeneity of single cell cytokine gene expression in clonal T cell populations.
- Characterization of avian natural killer cells and their intracellular CD3 protein complex.
- Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody. Long-term followup of CD4+ T cell counts.
- Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody.
- Cyclosporin A-induced autoimmune disease in mice.
- Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis.
- Intestinal T lymphocytes in the chicken express an integrin-like antigen.
- Total lymphoid irradiation in the treatment of early or recurrent heart rejection.
- Regulation of mucosal responses by CD4+ T lymphocytes: effects of anti-L3T4 treatment on the gastrointestinal immune system.
- Analysis of gamma delta T cells in the chicken.
- Reticular cells in peripheral lymphoid tissues express the phosphatidylinositol-linked BP-3 antigen.
- Avian T cell ontogeny.
- A third sublineage of avian T cells can be identified with a T cell receptor-3-specific antibody.
- Development of cytoplasmic CD3+/T cell receptor-negative cells in the peripheral lymphoid tissues of chickens.
- Effect of cyclosporin A on the ontogeny of different T cell sublineages in chickens.
- Ontogeny of T cell receptors in the chicken thymus.
- T cell differentiation in birds.
- Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras.
- Cytoplasmic CD3+ surface CD8+ lymphocytes develop as a thymus-independent lineage in chick-quail chimeras.
- Coronary artery to right ventricle fistula in heart transplant recipients: a complication of endomyocardial biopsy.
- Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humans.
- Functional and morphological studies of long-term islet allografts in the renal subcapsular space of the BB/W rat.
- T-cell development in birds.
- Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.
- The effects of immunosuppressive pharmacological agents on the induction of cytotoxic and suppressor T lymphocytes in vitro.
- Lack of an obligate role for IFN-gamma in the primary in vitro mixed lymphocyte response.
- Characterization of the avian T cell receptor.
- Alloantigen-specific suppressor T cells are not inhibited by cyclosporin A, but do require IL 2 for activation.
- Effect of cyclosporine and low-temperature culture on prevention of rejection of islet xenografts (rat-to-mouse).
- The effect of cyclosporin-A, low-temperature culture, and anti-Ia antibodies on prevention of rejection of rat islet allografts.
- A new neonatal short limbed dwarfism.
- Ir gene control of immune responses to insulins. II. Phenotypic differences in T cell activity among nonresponder strains of mice.
- T cell-independent responses to an Ir gene-controlled antigen. I. Characteristics of the immune response to insulin complexed to Brucella abortus.
- Ir gene control of the immune response to insulins. I. Pork insulin stimulates T cell activity in nonresponder mice.
Schools
Washington University St Louis
Barnes Jewish Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Hospital
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University of Alabama Hospital -
Birmingham Veterans Affairs Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1770596454 |
| Last Name Of The Provider | BUCY |
| First Name Of The Provider | RALPH |
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