Professor, Medicine, UCSD School of Medicine
Internal Medicine
Dr. Renate B. Pilz, MD
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Renate Pilz practices Internal Medicine. She attended Hannover Medical School. She received awards:"Elected Member". Renate Pilz is also published. She has 91 publications published. The lastest publication: "Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression.'
Publications
- Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.
- Soluble guanylate cyclase as a novel treatment target for osteoporosis.
- Akt phosphorylation and regulation of transketolase is a nodal point for amino Acid control of purine synthesis.
- CD20-positive plasmablastic lymphoma with excellent response to bortezomib combined with rituximab.
- Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate.
- Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase.
- A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension.
- Rho Isoform-specific Interaction with IQGAP1 Promotes Breast Cancer Cell Proliferation and Migration.
- Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransduction.
- Pro-survival effects of 17?-estradiol on osteocytes are mediated by NO/cGMP via differential actions of PKG I and II.
- A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring.
- New facile method to measure cyanide in blood.
- Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts.
- Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.
- A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
- The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.
- Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster.
- Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo.
- A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase.
- The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide.
- Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts.
- The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis.
- Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
- Cyanide detoxification by the cobalamin precursor cobinamide.
- Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif.
- Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3.
- Nitric oxide inhibits mammalian methylmalonyl-CoA mutase.
- Nitric oxide scavenging by the cobalamin precursor cobinamide.
- Role of cyclic GMP in gene regulation.
- Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein...
- Regulation of gene expression by cyclic GMP.
- Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide.
- Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta.
- Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity.
- cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions.
- cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.
- Nitric oxide as a mediator of estrogen effects in osteocytes.
- Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor.
- Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5'' UTR.
- NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.
- Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells.
- Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins.
- Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB).
- Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase.
- Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase.
- Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression.
- Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway.
- Deficient post-translational processing of Rap 1A in variant HL-60 cells.
- Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differe...
- Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase.
- cAMP-induced NF-kappaB (p50/relB) binding to a c-myb intronic enhancer correlates with c-myb up-regulation and inhibition of erythroLeukemia cell differentiation.
- Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal.
- A low molecular weight substance purified from human placenta inhibits cAMP-dependent protein kinase and activates protein kinase C.
- Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroLeukemia cell differentiation and suppress erythroid-specific gene expression: correlation with ...
- A decrease in the intracellular guanosine 5'-triphosphate concentration is necessary for granulocytic differentiation of HL-60 cells, but growth cessation and differen...
- Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter.
- Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroLeukemia cells.
- Identification of a ras-related protein in murine erythroLeukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induc...
- Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation.
- Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells.
- cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroLeukemia cell differentiation.
- Basis of guanylate cyclase activation by carbon monoxide.
- A new spectrophotometric assay for enzymes of purine metabolism. IV. Determination of adenosine deaminase.
- A new spectrophotometric assay for enzymes of purine metabolism. III. Determination of purine nucleoside phosphorylases.
- The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes.
- [Oncocytes in thyroid Gland aspirates--differential diagnostic problem: tumor/thyroiditis].
- [Cytology and histomorphology of thyroiditis].
- [Immunologic and cytologic findings in the course of a complex thyroid diagnosis. Comparison of 2 patient groups].
- Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine.
- Regulation of human lymphoblast ecto-5'-nucleotidase by zinc.
- Regulation of human lymphoblast plasma membrane 5'-nucleotidase by zinc.
- A new spectrophotometric method for the determination of 5''-nucleotidase.
- Adenosine dialdehyde and nitrous oxide induce HL-60 differentiation.
- Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors.
- Experiences in diagnostics and treatment of medullary carcinoma.
- Thyroid Cancer--experiences in the Berlin area (epidemiology, treatment results, follow-up).
- Fine needle aspiration biopsy (FNAB) of thyroid in the diagnostics of thyroid Malignancies--a 12 years'' experience-report.
- Discrepancies in diagnostic immunological parameter in Graves'' disease.
- Nucleotide sequence of the Chinese hamster ornithine decarboxylase gene.
- Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts.
- The synthesis of phosphoribosylpyrophosphate from glucose decreases during amino acid starvation of human lymphoblasts.
- Molecular and genetic characterization of an ornithine decarboxylase-deficient Chinese hamster cell line.
- Chemically induced murine erythroLeukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.
- Studies on cytosolic guanylate cyclase from human placenta.
- Laccase-catalysed synthesis of coupling products of phenolic substrates in different reactors.
- Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells.
- Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors.
- The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.
- cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity.
- Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote.
Conditions Treated
- Acute Leukemia
- Adrenal Gland Cancer
- Anemia
- Breast Cancer
- View All
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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University of California San Diego -
Hannover Medical School
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