Physician
Allergy & Immunology
Dr. Reuben P. Siraganian, MD
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Reuben P. Siraganian, MD works in the field of Allergy & Immunology. He studied medicine at State University of New York Downstate Medical Center College of Medicine. Reuben Siraganian is a published doctor. He has 101 papers published. The most current publication "Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis."
Publications
- Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.
- Tyrosines in the carboxyl terminus regulate Syk kinase activity and function.
- Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.
- The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
- IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species.
- TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.
- Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
- Mast cell-specific gangliosides and FcepsilonRI follow the same endocytic pathway from lipid rafts in RBL-2H3 cells.
- Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.
- Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells.
- Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
- Identification and characterization of undifferentiated mast cells in mouse bone marrow.
- Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation.
- Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
- Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells.
- Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells.
- The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells.
- The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis.
- Characterization of monoclonal antibodies to fimbria-associated adhesins of Bacteroides loescheii PK1295.
- Establishment of four mouse mastocytoma cell lines.
- Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.
- Protein tyrosine kinase Syk in mast cell signaling.
- Mast cell signal transduction from the high-affinity IgE receptor.
- FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
- Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.
- Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants.
- The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6.
- Use of adhesin-specific monoclonal antibodies to identify and localize an adhesin on the surface of Capnocytophaga gingivalis DR2001.
- Dual role of the CD44 molecule in T cell adhesion and activation.
- Localization and enumeration of fimbria-associated adhesins of Bacteroides loescheii.
- Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N omega-cyanoguanidino moieties.
- Fine specificity of the IgE interaction with the low and high affinity Fc receptor.
- Differential requirements of B cells from normal and allergic subjects for the induction of IgE synthesis by an alloreactive T cell clone.
- Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate.
- Destruction of rabbit platelets in the allergic response of sensitized leukocytes. II. Evidence for basophil involvement.
- Lysis of rabbit platelets by F(ab'') 2 antibody fragments.
- Platelet requirement in the interaction of the complement and clotting systems.
- Immunologic mechanisms of platelet damage.
- Platelet injury due to activation of the alternate complement pathway.
- Allergy to human seminal plasma.
- Basophil activation by concanavalin A: characteristics of the reaction.
- The allergic response of rabbit platelets. I. Membrane permeability changes.
- The allergic response of rabbit platelets. II. Dependence on magnesium.
- The biologic activities of guinea pig antibodies. I. Separation of gamma1 and gamma2 immunoglobulins and their participation in allergic reactions of the immediate type.
- Antigenic release of histamine from rabbit leukocytes.
- The allergic response of rabbit leukocytes and platelets.
- An automated continuous-flow system for the extraction and fluorometric analysis of histamine.
- The allergic response of rabbit platelets. 3. Its cytotoxic nature.
- The use of monoclonal antibodies in the study of lactose-sensitive adherence of Actinomyces viscosus T14V.
- Detection and localization of a lectin on Actinomyces viscosus T14V by monoclonal antibodies.
- Receptor cross-linking and histamine release in basophils.
- Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemia basophils.
- Studies on the allergenic significance and structure of rat serum albumin.
- Enhancement of IgE-mediated histamine release from human basophils by immune-specific lymphokines.
- Fc (IgG) receptors on rat basophilic leukemia cells.
- Effect of inhibitors of transmethylation on histamine release from human basophils.
- IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones.
- Enhancing the frequency of antigen-specific hybridomas.
- Allergenic and antigenic properties of bovine serum albumin.
- Influence of anions, cations and osmolarity on IgE-mediated histamine release from human basophils.
- Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
- Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: reconstitution by hybridization.
- IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid.
- Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophilic leukemia cells.
- Variants of the rat basophilic leukemia cell line for the study of histamine release.
- A method for determining whether the descending limb of a biphasic histamine release curve reflects insufficient cross-linking.
- Mouse mast cell activation and desensitization for immune aggregate-induced histamine release.
- Inhibition of histamine release and phosphatidylcholine metabolism by 5''-deoxy-5''-isobutylthio-3-deazaadenosine.
- Food allergens and basophil histamine release in recurrent aphthous stomatitis.
- Cell-bound and circulating IgE antibody to herpes simplex virus.
- Cell cycle associated changes in histamine release from rat basophilic leukemia cells separated by counterflow centrifugal elutriation.
- Arachidonic acid release during IgE- and Ca2+ -ionophore activation of rat basophilic leukemia cells.
- Skin tests and blood leukocyte histamine release of patients with allergies to laboratory animals.
- Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.
- Methods of enhancing the frequency of antigen-specific hybridomas.
- Monoclonal antibody against human interleukin 2 (IL 2). I. Purification of IL 2 for the production of monoclonal antibodies.
- IgE antibody suppression following aerosol exposure to antigens.
- Efficacy and specificity of immunotherapy with laboratory animal allergen extracts.
- Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine ...
- The receptor with high affinity for IgE on rat mast cells is a functional receptor for rat IgG2a.
- Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP.
- Protein tyrosine phosphatase activity associates with the high affinity IgE receptor and dephosphorylates the receptor subunits, but not Lyn or Syk.
- Mouse 3T3 fibroblasts induce rat basophilic leukemia (RBL-2H3) cells to acquire responsiveness to compound 48/80.
- Mechanism of action of concanavalin A on human basophils.
- Complement-induced histamine release from human basophils. I. Generation of activity in human serum.
- Unique serum requirement for histamine release from human basophils.
- Immunologic studies of a patient with seminal plasma allergy.
- Automated histamine release. A method for in vitro allergy diagnosis.
- Ionophore A-23187 induced histamine release from rat mast cells and rat basophil leukemia (RBL-1) cells.
- Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction.
- Automated histamine analysis for in vitro allergy testing. I. A method utilizing allergen-induced histamine release from whole blood.
- Histamine release by chemotactic, formyl methionine-containing peptides.
- Histamine release from cultured human basophils: lack of histamine resynthesis after antigenic release.
- Automated histamine analysis for in vitro allergy testing. II. Correlation of skin test results with in vitro whole blood histamine release in 82 patients.
- Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents.
- Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon.
- Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells.
- Mechanism of histamine release by formyl methionine-containing peptides.
- The mechanism of basophil histamine release in patients with periodontal disease.
- Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis.
Schools
Suny Downstate Medical Center
Baltimore City Hospital
Baltimore City Hosps
Johns Hopkins Hospital
Doctors Specialties
- Allergy
- Immunology
Accepted Insurances
Education
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Johns Hopkins University -
Johns Hopkins Bayview Medical Center -
State University of New York Downstate Medical Center College of Medicine
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