Associate Professor of Medicine, Beth Israel Deaconess Medical Center
Internal Medicine
Dr. Robert C. Flaumenhaft, MD
|
|
Give Review
Robert Flaumenhaft works in the field of Internal Medicine. He researched medicine at NYU School of Medicine. Robert Flaumenhaft is also a published doctor. He has 65 paper published. The most recent paper is: Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4.
Publications
- Extracellular Thiol Isomerases and Their Role in Thrombus Formation.
- Bioengineering in Platelet Biology.
- AntiCoagulation inhibits tumor cell mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.
- Advances in platelet granule biology.
- Protein disulfide isomerase as an antithrombotic target.
- Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis.
- Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.
- Platelet granule exocytosis: a comparison with chromaffin cells.
- A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion.
- Phosphatidylinositol 4,5-bisphosphate mediates Ca2+-induced platelet alpha-granule secretion: evidence for type II phosphatidylinositol 5-phosphate 4-kinase function.
- Ultrastructural localization of vesicle-associated membrane protein(s) to specialized membrane structures in human pericytes, vascular smooth muscle cells, endothelial...
- Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling...
- Inhibition of calpain blocks platelet secretion, aggregation, and spreading.
- Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets.
- Alpha-granule secretion from alpha-toxin permeabilized, MgATP-exposed platelets is induced independently by H+ and Ca2+.
- Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4.
- Activation of latent transforming growth factor beta.
- Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.
- Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term stimulation of plasminogen activator pr...
- Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor.
- Mechanisms controlling the extracellular activity of basic fibroblast growth factor and transforming growth factor.
- Extracellular matrix regulation of growth factor and protease activity.
- Growth factor control of extracellular proteolysis.
- Interaction of basic fibroblast growth factor with extracellular matrix and receptors.
- Cell density dependent effects of TGF-beta demonstrated by a plasminogen activator-based assay for TGF-beta.
- The extracellular regulation of growth factor action.
- Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.
- Discovery-based strategies for studying platelet function.
- Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors.
- Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.
- The platelet as a model for chemical genetics.
- Molecular basis of platelet granule secretion.
- Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion.
- SNARE protein degradation upon platelet activation: calpain cleaves SNAP-23.
- Subcellular distribution of 3 functional platelet SNARE proteins: human cellubrevin, SNAP-23, and syntaxin 2.
- SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane.
- Platelets possess and require an active protein palmitoylation pathway for agonist-mediated activation and in vivo thrombus formation.
- Localization and quantification of platelet-rich thrombi in large blood vessels with near-infrared fluorescence imaging.
- Formation and fate of platelet microparticles.
- Different strokes for rodent folks.
- Protein palmitoylation in signal transduction of hematopoietic cells.
- Phosphatidylinositol 4,5-bisphosphate regulates activation-induced platelet microparticle formation.
- Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo.
- The actin cytoskeleton differentially regulates platelet alpha-granule and dense-granule secretion.
- Platelet permeabilization.
- In vivo models of platelet function and Thrombosis: study of real-time thrombus formation.
- Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels.
- Platelets get the message.
- Proteomic analysis of palmitoylated platelet proteins.
- Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.
- Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein.
- Filling a void in Gray Platelets.
- Platelet- and megakaryocyte-derived microparticles.
- The selective estrogen receptor modulator DT56a (Femarelle) does not affect platelet reactivity in normal or thrombophilic postmenopausal women.
- Clinical relevance of microparticles from platelets and megakaryocytes.
- The platelet actin cytoskeleton associates with SNAREs and participates in alpha-granule secretion.
- Getting in shape with RanBP10.
- Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging.
- Targeting platelet G-protein coupled receptors (GPCRs): looking beyond conventional GPCR antagonism.
- Platelet alpha-granules: basic biology and clinical correlates.
- Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.
- Association of oral but not transdermal estrogen therapy with enhanced platelet reactivity in a subset of postmenopausal women.
- Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles.
- Inhibition of Protein Disulfide Isomerase in Thrombosis.
Schools
New York University School Of Medicine
New Eng Med Center
Beth Israel Deaconess Med Center
Conditions Treated
- Antiphospholipid Syndrome (APS)
- Coagulation Disorders (incl. Hemophilia)
- Hypercoagulable State
- Venous Embolism and Thrombosis
- View All
Doctors Specialties
- Hematology
- Internal Medicine
Accepted Insurances
Education
-
Tufts Medical Center -
NYU School of Medicine
Hospital
-
Beth Israel Deaconess Medical Center
Helpful Reviews
Similar Doctors
|
|
Dr. Milad Sharifpour, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amelia E. Huck, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Sonali M. Shah, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Christopher J. Gibson, MD |
|
|
Dr. Apara R. Dave, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Bimalangshu R. Dey, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Ziv Paz, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Karen K. Ballen, MD
This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Patricia L. Pringle, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Benjamin L. Lampson, MD |
|
|
Dr. Megan J. Ritter, MD |
|
|
Dr. Denise De Las Nueces, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Lisa R. Hirschhorn, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Dongsheng Xu, MD
This Doctor is OpenDoctor Recommended.
|