Associate Professor, Pediatrics-Children's Hospital, Harvard Medical School
Pediatric Rheumatology
Dr. Robert C. Fuhlbrigge, MD
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Robert Fuhlbrigge is an expert in the field of Pediatric Rheumatology. He went to Washington University School of Medicine in St. Louis. He received 2 awards: "Fellow" and "Fellow (FACR)". Robert C. Fuhlbrigge has written publications. He has 68 publications published with PubMed. The lastest publication is: 'Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance.'
Publications
- Nonapoptotic and Extracellular Activity of Granzyme B Mediates Resistance to Regulatory T Cell (Treg) Suppression by HLA-DR-CD25hiCD127lo Tregs in Multiple Sclerosis a...
- A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome.
- A28: Description of the Juvenile Localized Scleroderma Subgroup of the CARRA Registry.
- CCR7 Plays No Appreciable Role in Trafficking of Central Memory CD4 T Cells to Lymph Nodes.
- Urine proteomics for discovery of improved diagnostic markers of Kawasaki Disease.
- Development of consensus treatment plans for Juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in Juvenile localized scleroderma.
- Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
- Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells.
- The immune system, the skin, and childhood rheumatic Disease.
- TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.
- Immunology and skin Disease 2009: frontiers in cutaneous immunology.
- Complete and sustained remission of juvenile Dermatomyositis resulting from aggressive treatment.
- Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.
- Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus.
- Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
- The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
- Meeting report of immunology and skin Disease: new perspectives.
- T-cell distribution and adhesion receptor expression in metastatic melanoma.
- Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune Diseases.
- The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
- Dynamic programming of CD8+ T cell trafficking after live viral immunization.
- Neonatal-onset multisystem inflammatory Disease responsive to interleukin-1beta inhibition.
- CD43 is a ligand for E-selectin on CLA+ human T cells.
- Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic Arthritis.
- Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.
- E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation...
- Rituximab therapy for multisystem autoimmune Diseases in pediatric patients.
- Raynaud's phenomenon in children: a retrospective review of 123 patients.
- Increased CCR4 expression in cutaneous T cell lymphoma.
- Aggressive management of juvenile Dermatomyositis results in improved outcome and decreased incidence of calcinosis.
- Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots.
- Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1.
- Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity.
- Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen.
- CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.
- A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.
- Psoriatic eruption in Kawasaki Disease.
- Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance.
- The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes.
- L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endotheli...
- P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions.
- Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.
- Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins.
- A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
- Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow.
- Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions.
- Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions.
- Low doses of interferon alpha result in more effective clinical natural killer cell activation.
- Separation of human natural killer cell subpopulations differentially responsive to interferon potentiation.
- Membrane IL-1: a key protein in antigen presentation.
- Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.
- Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.
- Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.
- Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse.
- Regulation of antigen presentation. II. Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells.
- Molecular biology and genetics of interleukin-1.
- Immune surveillance in the skin: mechanisms and clinical consequences.
- WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.
- The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions.
- Adhesion molecules in cutaneous immunity.
- Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus.
- Identification of cells initiating human melanomas.
- Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
- Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma.
- Update in paediatric Vasculitis.
- Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects : Current knowledge assembled at an international workshop at ...
- Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay.
Schools
Washington Center School of Medicine
St Louis Children39s Hospital
Children39s Hospital Boston
Northwick Park Hospital
Conditions Treated
- Arthritis
- Dermatomyositis
- Fibromyalgia
- Juvenile Chronic Arthritis
- View All
Doctors Specialties
- Pediatric Rheumatology
Accepted Insurances
Awards
- Fellow
- Fellow (FACR)
Education
-
Boston Children's Hospital -
Washington University School of Medicine in St. Louis
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