Physician
Internal Medicine
Dr. Robert E. Vestal, MD
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Robert Vestal works in the field of Internal Medicine. He graduated from University of California San Francisco School of Medicine. University of California San Francisco School of Medicine is a top medical college. University of California San Francisco School of Medicine is ranked 3/3 in Research/PrimaryCare. Doctor Robert E. Vestal, MD is also a published MD. He has 67 publication published. The most recent publication is: Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
Publications
- Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors.
- Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.
- What's best for the elderly research subject?
- Streptococcus pneumoniae-induced pulmonary hypertension and systemic hypotension in anesthetized sheep.
- Liver LDL receptor mRNA expression is decreased in human ApoB/CETP double transgenic mice and is regulated by diet as well as the cytokine oncostatin M.
- Effects of adenosine on polymorphonuclear leucocyte function, cyclic 3'': 5''-adenosine monophosphate, and intracellular calcium.
- Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3',5'-adenosine monophosphate.
- Oncostatin M activates low density lipoprotein receptor gene transcription in sterol-repressed liver cells.
- Oncostatin M-specific receptor expression and function in regulating cell proliferation of normal and malignant mammary epithelial cells.
- Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.
- Cigarette smoking and theophylline metabolism: effects of cimetidine.
- Additive effect of theophylline on the cardiac response to isoproterenol.
- Theophylline clearance in patients with severe chronic obstructive pulmonary disease receiving supplemental oxygen and the effect of acute hypoxemia.
- Cigarette smoking and theophylline metabolism: effects of phenytoin.
- Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose.
- Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
- Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation.
- Effects of cyclopentyladenosine on isoproterenol response in adult and senescent cardiac tissue from Fischer 344 rats.
- Aging and pharmacology.
- Species comparison of adenosine A1 receptors in isolated mammalian atrial and ventricular myocardium.
- CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis.
- Oncostatin M-mediated transcriptional suppression of the c-myc gene in breast cancer cells.
- Fulminant hepatic failure following low-dose sustained-release niacin therapy in hospital.
- Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
- Cloning and characterization of human oncostatin M promoter.
- Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging.
- Relation between plasma and saliva concentrations of enoxacin, ciprofloxacin, and theophylline.
- Peripheral mononuclear leucocyte beta adrenoceptors and non-specific bronchial responsiveness to methacholine in young and elderly normal subjects and asthmatic patients.
- Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids.
- Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes.
- Novel mechanism of transcriptional activation of hepatic LDL receptor by oncostatin M.
- Geriatric clinical pharmacologist and medical oncologist: a new partnership?
- The clinical pharmacologist: an endangered species?
- Inhibition of theophylline metabolism by mexiletine in young male and female nonsmokers.
- Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst.
- Increased ventricular response rate during exercise in patients with atrial fibrillation treated with theophylline.
- Clinical significance of crepitations in elderly patients following acute hospital admission: a prospective study.
- Reduced subjective awareness of bronchoconstriction provoked by methacholine in elderly asthmatic and normal subjects as measured on a simple awareness scale.
- Workshop on problem-based learning as a method for teaching clinical pharmacology and therapeutics in medical school.
- Impaired beta-adrenoceptor function, increased leukocyte respiratory burst, and bronchial hyperresponsiveness.
- Relationship between nonspecific bronchial responsiveness to methacholine and peripheral mononuclear leukocyte beta-adrenergic receptor function in young drug-naive su...
- The effect of tocainide on theophylline metabolism.
- Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor.
- Species comparison of adenosine and beta-adrenoceptors in mammalian atrial and ventricular myocardium.
- Characterization of the independent and combined effects of two inhibitors on oxidative drug metabolism in rat liver microsomes.
- Theophylline metabolism in healthy nonsmokers and in patients with insulin-dependent diabetes mellitus.
- Clinical pharmacology: present status and projections for the future.
- Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.
- Aging and determinants of hepatic drug clearance.
- Methylxanthine effects on caudate dopamine release as measured by in vivo electrochemistry.
- Dose-dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics.
- Impaired bronchodilator response to albuterol in healthy elderly men and women.
- Simultaneous determination of theophylline, enoxacin and ciprofloxacin in human plasma and saliva by high-performance liquid chromatography.
- Pharmacokinetic optimisation of drug therapy in elderly patients.
- Management of drug therapy in the elderly.
- Age-related characterization of atrial adenosine A1 receptor activation: direct effects on chronotropic and inotropic function in the Fischer 344 rat.
- Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
- Quantification of the voltage-response relationship between punctate and field electrical stimulation and the function of isolated rat left atria and papillary muscles.
- Aging increases the cardiotoxicity of daunorubicin and daunorubicinol in the rat.
- Aging and the response to inhibition and induction of theophylline metabolism.
- Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.
- Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female ...
- Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.
- Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat.
- Effect of phenytoin on the pharmacokinetics of doxorubicin and doxorubicinol in the rabbit.
- Age-related effects in rabbit hearts of N6-R-phenylisopropyladenosine, an adenosine A1 receptor agonist.
Schools
University of California At San Francisco
Colo Med Center
Vanderbilt
Doctors Specialties
- Geriatric Medicine
- Internal Medicine
Accepted Insurances
Education
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University of Colorado -
University of California San Francisco School of Medicine
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