Physician
Pathology
Dr. Samuel A. Santoro, MD
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Samuel Santoro works in the field of Pathology. He went to medical school at Vanderbilt University School of Medicine. He over the years received 1 awards: "Elected Member". Samuel A. Santoro, MD is a published doctor and has 101 publications published. The lastest was: 'Integrins and the kidney: biology and pathobiology.'
Publications
- Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach.
- Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity.
- Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.
- Negative regulation of activated alpha-2 integrins during thrombopoiesis.
- The MD/PhD pathway to a career in laboratory medicine.
- Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression.
- Beta1 integrin mediates internalization of mammalian reovirus.
- Novel collectin/C1q receptor mediates mast cell activation and innate immunity.
- GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.
- Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.
- Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.
- The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo.
- Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk.
- The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis.
- α2β1 Integrin, GPVI Receptor, and Common FcRγ Chain on Mouse Platelets Mediate Distinct Responses to Collagen in Models of Thrombosis.
- α2β1 Integrin.
- The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids.
- Isolation and characterization of thrombospondin.
- A monoclonal antibody against human thrombospondin inhibits platelet aggregation.
- Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin.
- Characterization of the platelet agglutinating activity of thrombospondin.
- Inhibition of platelet aggregation by fibronectin.
- Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin.
- Antiphospholipid antibodies and thrombotic predisposition: underlying pathogenetic mechanisms.
- Primary hemostasis (collagen-platelet interaction): introduction.
- Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins.
- Thrombin enhanced adhesion of platelets to von Willebrand factor substrates.
- The nature of interactions between tissue-type plasminogen activator and platelets.
- Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical signif...
- The effects of hemodialysis on platelet deposition in prosthetic graft fistulas.
- Effect of aprotinin on activated clotting time, whole blood and plasma heparin measurements.
- Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations.
- In vitro reversal of heparin effect with heparinase: evaluation with whole blood prothrombin time and activated partial thromboplastin time in cardiac surgical patients.
- Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation.
- Interactions of exercise, coagulation, platelets, and fibrinolysis--a brief review.
- Activated platelets express IL-1 activity.
- Divalent cation-dependent structure in the platelet membrane glycoprotein Ia-IIa (VLA-2) complex.
- The effects of hemodialysis on platelet activation with new and reprocessed regenerated cellulose dialyzers.
- Integrins and the kidney: biology and pathobiology.
- Effects of antiplatelet drugs on dialysis-associated platelet deposition in polytetrafluoroethylene grafts.
- Multiple episodes of thrombosis with biventricular support devices with inadequate anticoagulation and evidence of accelerated intravascular coagulation.
- More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT.
- Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients.
- Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements.
- Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood.
- Evaluation of complete blood count results from a new, on-site hemocytometer compared with a laboratory-based hemocytometer.
- On-site prothrombin time, activated partial thromboplastin time, and platelet count. A comparison between whole blood and laboratory assays with coagulation factor ana...
- The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac o...
- Effect of heparin on whole blood activated partial thromboplastin time using a portable, whole blood coagulation monitor.
- Preparation of soluble peptide libraries: application to studies of platelet adhesion sequences.
- Adsorption of von Willebrand factor by fibrillar collagen--implications concerning the adhesion of platelets to collagen.
- Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fi...
- Collagen-mediated platelet aggregation. Evidence for multivalent interactions of intermediate specificity between collagen and platelets.
- Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing.
- Collagen-mediated platelet aggregation: the role of multiple interactions between the platelet surface and collagen.
- Platelet-collagen adhesion.
- Platelet interactions with the vessel wall and prosthetic grafts.
- Platelet-collagen adhesion-membrane fluidity and the development of high affinity adhesion through multiple interacting sites.
- Fibronectin and the multiple interaction model for platelet-collagen adhesion.
- Thrombospondin and the adhesive behavior of platelets.
- Modulation of an RGDS binding site on the platelet membrane glycoprotein IIb-IIIa complex.
- Bone matrix constituents stimulate interleukin-1 release from human blood mononuclear cells.
- Mechanisms of vascular graft thrombosis: role of altered canine platelet sensitivity to thromboxane.
- Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis.
- Assessment of interference by heparin cofactor II in the DuPont aca antithrombin-III assay.
- New RGD analogue inhibits human platelet adhesion and aggregation and eliminates platelet deposition on canine vascular grafts.
- Decorin binds near the C terminus of type I collagen.
- The dualistic mechanisms of platelet adhesion to von Willebrand factor substrates.
- Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element.
- Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen.
- Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility.
- ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction.
- Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA.
- Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase.
- Molecular basis of platelet adhesion to collagen.
- Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk.
- The alpha 2 beta 1 integrin binds to the CB4 peptide of the alpha 2(I) collagen chain.
- Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis.
- Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.
- Collagen-induced release of interleukin 1 from human blood mononuclear cells. Potentiation by fibronectin binding to the alpha 5 beta 1 integrin.
- Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogene...
- The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morp...
- Isolation and characterization of a platelet surface collagen binding complex related to VLA-2.
- The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen.
- Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.
- Ligand recognition by the I domain-containing integrins.
- Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation.
- Analysis of collagen receptors.
- Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.
- Role of the alpha1 and alpha2 integrin cytoplasmic domains in cell morphology, motility and responsiveness to stimulation by the protein kinase C pathway.
- Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin.
- The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.
- Dependence of plasmin-mediated degradation of platelet adhesive receptors on temperature and Ca2+.
- Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors.
- PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta.
- A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling.
- Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.
- Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.
- The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expre...
- Induced cell surface expression of functional alpha 2 beta 1 integrin during megakaryocytic differentiation of K562 leukemic cells.
Schools
Vanderbilt University
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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Vanderbilt University School of Medicine
Hospital
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Vanderbilt Hospital and Clinics
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