Senior Director, Clinical Development
Anesthesiology
Dr. Sandra R. Chaplan, MD
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Sandra R. Chaplan practices Anesthesiology. She went to Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18 in research and 49 in primary care medicine Sandra Chaplan is a published physician. She has 53 papers published. The most current publication "Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain."
Publications
- Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure-mutagenicity relationships for arylamine metabolites.
- Discovery of a novel series of selective HCN1 blockers.
- Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
- Sodium channel blockers for the treatment of neuropathic pain.
- Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide...
- Activation of TRPA1 by farnesyl thiosalicylic acid.
- Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transi...
- Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spin...
- Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (...
- Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
- Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp.
- The role of pacemaker currents in neuropathic pain.
- Semi-quantitative real-time PCR for pain research.
- Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
- Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
- 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
- HCN channels as targets for drug discovery.
- Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
- Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.
- Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
- Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms.
- Trypanosoma cruzi. Factors modifying ingestion and fate of blood form trypomastigotes.
- Trypanosoma cruzi: induction of microbicidal activity in human mononuclear phagocytes.
- Trypanosoma cruzi. Surface antigens of blood and culture forms.
- Trypanosoma cruzi: in vivo and in vitro correlation between T-cell activation and susceptibility in inbred strains of mice.
- Cerebrospinal fluid beta-endorphin in models of hyperalgesia in the rat.
- Vincristine-induced allodynia in the rat.
- Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.
- Neuropathic pain: role of voltage-dependent calcium channels.
- Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development.
- Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain.
- The respiratory effects of the cytokine regulating agent HP 228 alone and in combination with morphine in human volunteers.
- Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
- Spinal pharmacology of tactile allodynia in diabetic rats.
- Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
- An improved method for the measurement of lidocaine and its metabolites in rat plasma.
- Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
- Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor.
- Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
- Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia.
- Quantitative assessment of tactile allodynia in the rat paw.
- Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists.
- Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats.
- Continuous epidural hydromorphone for postthoracotomy pain relief.
- Adrenal suppression and paraspinal corticosteroids.
- Morphine and hydromorphone epidural analgesia. A prospective, randomized comparison.
- Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.
- Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse.
- A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats.
- Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.
- HCN pacemaker channels and pain: a drug discovery perspective.
- Once is not enough: improved efficacy following repeated dosing with a TRPV1 antagonist.
Schools
Weill Cornell Medical College
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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University of California San Diego -
Stanford University -
University of Washington -
Weill Cornell Medical College of Cornell University
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