Professor of Medicine, Case West Res University
Hematology
Dr. Sanford D. Markowitz, MD
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Sanford Markowitz is an expert in the field of Hematology. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He has 5 awards "America's Top Doctors", "America's Top Doctors for Cancer", "Northern Ohio Live", "Investigator Alumnus" and "Elected Member". Sanford Markowitz has written publications. He has 68 publications published with PubMed. The lastest publication is: 'Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.'
Publications
- Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.
- Novel recurrently mutated genes in African American colon Cancers.
- The Molecular Pathogenesis of ColoRectal Cancer and Its Potential Application to ColoRectal Cancer Screening.
- Sulindac Reversal of 15-PGDH Mediated Resistance to Colon Tumor Chemoprevention with NSAIDs.
- Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.
- Barrett's Esophagus Translational Research Network (BETRNet): The Pivotal Role of Multi-institutional Collaboration in Esophageal Adenocarcinoma Research.
- Aspirin and the Risk of ColoRectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD).
- Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression from Adenoma to ColoRectal Cancer.
- Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
- NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in ColoRectal Cancer.
- Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions.
- Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
- Colonic 15-PGDH Levels Are Stable Across Distance and Time and Are Not Perturbed by Aspirin Intervention.
- Vimentin in Upper Gastrointestinal Pathologies--Response.
- Variation in Age at Cancer Diagnosis in Familial versus Nonfamilial Barrett's Esophagus.
- Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
- Emerging Paradigms for the Initiation of Mucin-type Protein O-Glycosylation by the Polypeptide GalNAc Transferase Family of Glycosyltransferases.
- Confirmation of linkage to and localization of familial colon Cancer risk haplotype on chromosome 9q22.
- Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
- DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.
- Molecular origins of cancer: Molecular basis of coloRectal cancer.
- BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to Cancer cells.
- Sensitive digital quantification of DNA methylation in clinical samples.
- Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon Cancers.
- Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon Cancer patients.
- 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
- The effectiveness of colonoscopy in reducing mortality from coloRectal cancer.
- A simplified, noninvasive stool DNA test for coloRectal cancer detection.
- The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon Cancers.
- Integrated Analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.
- NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung Cancer.
- Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
- Ugene, a newly identified protein that is commonly overexpressed in Cancer and binds uracil DNA glycosylase.
- ColoRectal neoplasia goes with the flow: prostaglandin transport and termination.
- The aberrant methylation of TSP1 suppresses TGF-beta1 activation in coloRectal cancer.
- 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung Cancer.
- Comparative lesion sequencing provides insights into tumor evolution.
- Identification of susceptibility genes for Cancer in a genome-wide scan: results from the colon neoplasia sibling study.
- Mutational inactivation of TGFBR2 in microsatellite unstable colon Cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming g...
- The genomic landscapes of human breast and coloRectal cancers.
- Aspirin and colon Cancer--targeting prevention?
- Is TGFBR1*6A a susceptibility allele for nonsyndromic familial coloRectal neoplasia?
- Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.
- Clinical trial resources on the internet must be designed to reach underrepresented minorities.
- The consensus coding sequences of human breast and coloRectal cancers.
- 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
- CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of coloRectal cancer.
- Proliferation and Cdk4 expression in microsatellite unstable colon Cancers with TGFBR2 mutations.
- Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability Cancers.
- Detection in fecal DNA of colon Cancer-specific methylation of the nonexpressed vimentin gene.
- Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with coloRectal polyps.
- 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal Cancers.
- C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon Cancer.
- Three classes of genes mutated in coloRectal cancers with chromosomal instability.
- Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in coloRectal cancer.
- PRL-3 expression in metastatic Cancers.
- A subset of familial coloRectal neoplasia kindreds linked to chromosome 9q22.2-31.2.
- SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and Cancers.
- Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal Cancers.
- Hereditary colon Cancer genes.
- HLTF gene silencing in human colon Cancer.
- Focus on colon Cancer.
- Genetic and epigenetic alterations in colon Cancer.
- Mismatch repair and drug responses in Cancer.
- GNAS Mutations Identify a Set of Right-Sided, RAS Mutant, Villous Colon Cancers.
- Two Distinct Categories of Focal Deletions in Cancer Genomes.
- Genetic Variation in 15-Hydroxyprostaglandin Dehydrogenase and Colon Cancer Susceptibility.
Schools
Yale University School Of Medicine
University of Chicago
National Cancer Institute
Conditions Treated
- Anal and Rectal Cancer
- Anemia
- Breast Cancer
- ColoRectal Cancer
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Doctors Specialties
- Medical Oncology
- Oncology
- Hematology
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Northern Ohio Live
- Investigator Alumnus
- Elected Member
Education
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National Institutes of Health Clinical Center -
University of Chicago -
Yale University School of Medicine
Hospital
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University Hospitals Case Medical Center
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