Associate Professor, Medicine, University of Alabama School of Medicine

Pediatrics

Dr. Scott W. Blume, MD

Scott W. Blume, MD works in the field of Pediatrics. Scott W. Blume, MD is also a published physician. He has 18 paper published. The most recent paper is: The integral divalent cation within the intermolecular purine*purine. pyrimidine structure: a variable determinant of the potential for and characteristics of the trip...

Publications

Physiological Expression and Accumulation of the Products of Two Upstream Open Reading Frames Mrtl and MycHex1 Along with p64 and p67 Myc from the Human c-myc Locus.
Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation...
The human IGF1R IRES likely operates through a Shine-Dalgarno-like interaction with the G961 loop (E-site) of the 18S rRNA and is kinetically modulated by a naturally ...
mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network.
Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational c...
Inhibition of tumorigenicity by the 5'-untranslated RNA of the human c-myc P0 transcript.
The 5'-untranslated RNA of the human dhfr minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter.
The ELAV RNA-stability factor HuR binds the 5''-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated transla...
Evidence for differential ribonucleoprotein complex assembly in vitro on the 5''-untranslated region of the human IGF-IR transcript.
The integral divalent cation within the intermolecular purine*purine. pyrimidine structure: a variable determinant of the potential for and characteristics of the trip...
Triple helix formation by purine-rich oligonucleotides targeted to the human dihydrofolate reductase promoter.
Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.
Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter.
Divalent transition metal cations counteract potassium-induced quadruplex assembly of oligo(dG) sequences.
Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters.
Oncogenes, malignant transformation, and modern medicine.
SmtB-DNA and protein-protein interactions in the formation of the cyanobacterial metallothionein repression complex: Zn2+ does not dissociate the protein-DNA complex i...

Schools

University of Alabama At Birmingham

Doctors Specialties

Pediatrics

Accepted Insurances

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