Professor and Chief, Pediatric Hematology, Oncology and Stem Cell Transplantation, Program Co-Leader, Cancer Molecular Genetics, VCU Massey Cancer Center and Children's Hospital of Richmond
Pediatric Hematology & Oncology
Dr. Seth J. Corey, MD
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Doctor Seth J. Corey, MD is an expert in the field of Pediatric Hematology & Oncology. He studied medicine at Tulane University School of Medicine. He has 14 awards "America's Top Doctors", "Chicago Magazine: Top Doctors", "America's Top Doctors for Cancer", "Chicago Mag - Children's Health", "Top Pediatric Doctors (Hematology-Oncology)", "America's Top Doctors for Cancer (top 1%)", "Experts Directory", "Independent-Scientist Award", "AMA Florence Carter Fellowin Leukemia", "Michael E. Miller Young Investigator Award", "Fellow", "Physician-Scientist Award", "Marmelzat Foundation Award" and "Super Doctor". Seth Corey is a published MD. He has 91 papers published. The most current publication "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels."
Publications
- Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.
- Linking stress granulopoiesis to protein synthesis through GADD34.
- Pediatric myelodysplastic syndromes: they do exist!
- Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.
- Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).
- Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to Neutropenia.
- Shwachman-Diamond Syndrome: Diarrhea, no Longer Required?
- Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
- Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling.
- ELANE Mutations in Cyclic and Severe Congenital Neutropenia: Genetics and Pathophysiology.
- Drug repurposing in pediatrics and pediatric hematology oncology.
- How I treat: childhood CML.
- G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
- Slowly produced microRNAs control protein levels.
- Cdc42-interacting protein 4 promotes breast Cancer cell invasion and formation of invadopodia through activation of N-WASp.
- The hematologists' Maltese Falcon.
- Hematopoiesis and its disorders: a systems biology approach.
- Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.
- The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis.
- Flow cytometric determination of Src phosphorylation in pediatric patients treated with dasatinib.
- Pediatric therapy-related myelodysplastic syndrome/acute myeloid leukemia: the MD Anderson Cancer Center experience.
- Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma.
- A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.
- Src kinases in G-CSF receptor signaling.
- The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.
- G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid Cell growth.
- Regulation of JAK2 protein expression by chronic, pulsatile GH administration in vivo: a possible mechanism for ligand enhancement of signal transduction.
- New agents in the treatment of childhood leukemias and myelodysplastic syndromes.
- Targeted therapy: for kids, too.
- Complete remission following clofarabine treatment in refractory juvenile myelomonocytic leukemia.
- A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.
- G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.
- Microarray analysis of Lyn-deficient B Cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center.
- Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro.
- Deletional mutation of the external domain of the human granulocyte colony-stimulating factor receptor in a patient with severe chronic Neutropenia refractory to granu...
- Lyn regulates the Cell death response to ultraviolet radiation through c-Jun N terminal kinase-dependent Fas ligand activation.
- Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.
- Ex vivo expansion of megakaryocyte precursors from umbilical cord blood CD34 Cells in a closed liquid culture system.
- Identification of the presenilins in hematopoietic Cells with localization of presenilin 1 to neutrophil and platelet granules.
- Myelodysplastic syndromes: the complexity of stem-Cell diseases.
- Are kinases factors in core binding factor leukemia?
- The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
- Cancer cell migration: when red light switched to green.
- Granulocyte colony-stimulating factor receptor signaling defects from Neutropenia to leukemia.
- Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased Cell proliferation.
- Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations.
- Growth inhibition and apoptosis of myeloma Cells by the CDK inhibitor flavopiridol.
- Mitogenic synergy through multilevel convergence of hepatocyte growth factor and interleukin-4 signaling pathways.
- Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.
- Engagement of the B-Cell antigen receptor activates STAT through Lyn in a Jak-independent pathway.
- Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase.
- Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.
- Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.
- Implications for Src kinases in hematopoiesis: signal transduction therapeutics.
- Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
- Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.
- Therapeutic targeting of Src-kinase Lyn in myeloid leukemic Cell growth.
- Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast Cancer cells.
- The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.
- Physical and functional association of Fc mu receptor on human natural killer Cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine ...
- Lovastatin disrupts early events in insulin signaling: a potential mechanism of lovastatin's anti-mitogenic activity.
- Src-related protein tyrosine kinases in hematopoiesis.
- Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosp...
- Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.
- Point mutations in the conserved box 1 region inactivate the human granulocyte colony-stimulating factor receptor for growth signal transduction and tyrosine phosphory...
- FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host Disease in children undergoing bone marrow transplantation.
- Graft failure after an umbilical cord blood transplant in a patient with severe aplastic anemia.
- The use of counterflow centrifugal elutriation for the depletion of T Cells from unrelated donor bone marrow.
- Localization of the human gene for Src-related protein tyrosine kinase LYN to chromosome 8q11-12: a lymphoid signaling cluster?
- CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase...
- Signaling via Src family kinases is required for normal internalization of the receptor c-Kit.
- Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human ...
- Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.
- Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin.
- GIRK4 confers appropriate processing and Cell surface localization to G-protein-gated potassium channels.
- Granulocyte colony-stimulating factor and congenital Neutropenia--risk of leukemia?
- Src kinase-mediated signaling in leukocytes.
- Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived Cells.
- Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism.
- Divergent phosphotyrosine signaling via Fc gamma RIIIA on human NK Cells.
- The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs).
- Divergent signal transduction pathways and effects on natural killer Cell functions induced by interaction of Fc receptors with physiologic ligands or antireceptor ant...
- Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh.
- A non-classical translocation involving 17q12 (retinoic acid receptor alpha) in acute promyelocytic leukemia (APML) with atypical features.
- Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid.
- Clinical, genetic, and biochemical features of G-6PD(West Virginia).
- A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example.
- Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh.
- Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers.
- Stochastic Hypothesis of Transition from Inborn Neutropenia to AML: Interactions of Cell Population Dynamics and Population Genetics.
Schools
Tulane Univ Sch Of Med
St Louis Chldns Hospital
Boston Chldns Dana Farber Center
Harvard Med School
Tufts Med School
Conditions Treated
- Immune Thrombocytopenic Purpura (ITP)
- Liver Cancer
- Neutropenia
- Osteosarcoma
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- Chicago Magazine: Top Doctors
- America's Top Doctors for Cancer
- Chicago Mag - Children's Health
- Top Pediatric Doctors (Hematology-Oncology)
- America's Top Doctors for Cancer (top 1%)
- Experts Directory
- Independent-Scientist Award
- AMA Florence Carter Fellow in Leukemia
- Michael E. Miller Young Investigator Award
- Fellow
- Physician-Scientist Award
- Marmelzat Foundation Award
- Super Doctor
Education
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Tulane University School of Medicine
Hospital
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Lurie Children's Hospital of Chicago -
Northwestern Memorial Hospital
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