Associate Professor, Medicine, Vanderbilt University School of Medicine
Infectious Disease
Dr. Spyros Kalams, MD
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Spyros Kalams, MD is an expert in the field of Infectious Disease. He graduated from University of Connecticut School of Medicine. University of Connecticut School of Medicine has a rank of 60 in research and a 49 in primary care Spyros Kalams is a published MD as well. He has 101 publications published. The latest was: The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083.
- Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutat...
- Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals.
- Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1.
- Phase I/II Randomized Trial of Safety and Immunogenicity of LIPO-5 Alone, ALVAC-HIV (vCP1452) Alone, and ALVAC-HIV (vCP1452) Prime/LIPO-5 Boost in Healthy, HIV-1 Uninf...
- Envelope Variants Circulating as Initial Neutralization Breadth Developed in Two HIV-Infected Subjects Stimulate Multiclade Neutralizing Antibodies in Rabbits.
- OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis.
- Specificity and 6-Month Durability of Immune Responses Induced by DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-Like Particles.
- Cocaine Enhances HIV-1-Induced CD4(+) T-Cell Apoptosis: Implications in Disease Progression in Cocaine-Abusing HIV-1 Patients.
- Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery.
- Abacavir-reactive memory T cells are present in drug naïve individuals.
- B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade.
- Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial.
- Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection.
- Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV.
- A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204).
- Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins...
- Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults.
- Increased frequency of Regulatory T cells and T lymphocyte activation in persons with previously treated extrapulmonary Tuberculosis.
- HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable.
- Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384.
- Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.
- Postpartum viral load rebound in HIV-1-infected women treated with highly active antiretroviral therapy: AIDS Clinical Trials Group Protocol A5150.
- Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles.
- Characteristics of the earliest cross-neutralizing antibody response to HIV-1.
- Emerging studies of human HIV-specific antibody repertoires.
- Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.
- Re: Misleading comments in Ranganathan et al. "Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency viru...
- Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.
- Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant.
- Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.
- The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication.
- Despite biased TRBV gene usage against a dominant HLA B57-restricted epitope, TCR diversity can provide recognition of circulating epitope variants.
- Kinetic analysis by real-time PCR of hepatitis C virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV.
- Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positi...
- Suppression of HIV-specific and allogeneic T cell activation by human regulatory T cells is dependent on the strength of signals.
- On-chip counting the number and the percentage of CD4+ T lymphocytes.
- Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection.
- DC-Dielectrophoretic separation of biological cells by size.
- Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection.
- Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis.
- Evaluation of cellular immune responses in subjects chronically infected with HIV type 1.
- Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.
- Low CD4+ T cell nadir is an independent predictor of lower HIV-specific immune responses in chronically HIV-1-infected subjects receiving highly active antiretroviral ...
- Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
- Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.
- Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.
- Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials.
- Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotox...
- Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape.
- Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL.
- Soluble HIV-specific T cell receptor: expression, purification and analysis of the specificity.
- Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.
- Distinct molecular mechanisms account for the specificity of two different T-cell receptors.
- Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines.
- In vitro T lymphopoiesis of human and rhesus CD34+ progenitor cells.
- Generation of human T lymphocytes from bone marrow CD34+ cells in vitro.
- High-resolution analysis of T-cell receptor beta-chain repertoires using DNA heteroduplex tracking: generally stable, clonal CD8+ expansions in all healthy young adults.
- Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method.
- Analysis of the TCR beta variable gene repertoire in chimpanzees: identification of functional homologs to human pseudogenes.
- Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
- Interleukin-2 Increases CD4+ lymphocyte numbers but does not enhance responses to immunization: results of A5046s.
- Clonotype tracking of TCR repertoires during chronic virus infections.
- Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes.
- Vpr is preferentially targeted by CTL during HIV-1 infection.
- Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults.
- Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
- Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.
- Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
- Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-bindin...
- Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
- Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
- Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immu...
- Efficient generation of human T cells from a tissue-engineered thymic organoid.
- Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes.
- Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and ...
- Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the...
- Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active ant...
- Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
- Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.
- The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.
- Detection of HIV-1-specific CTLs in the semen of HIV-infected individuals.
- Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
- Latent infection of cells in HIV disease: abstract and commentary.
- Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans.
- HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
- Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR reper...
- The cytotoxic T-lymphocyte response in HIV-1 infection.
- Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.
- Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents.
- An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway al...
- Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
- Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
- Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.
- Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.
- Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.
- Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
- Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.
- Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognit...
- Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in...
Schools
Univ Of Ct Sch Of Med
Beth Israel Hospital
Massachusetts General Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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Massachusetts General Hospital -
Beth Israel Deaconess Medical Center -
University of Connecticut School of Medicine
Hospital
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Vanderbilt Hospital and Clinics
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1003903113 |
| Last Name Of The Provider | KALAMS |
| First Name Of The Provider | SPYROS |
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