Professor, Neurology, UCSF School of Medicine
Neurology
Dr. Stanley B. Prusiner, MD
Stanley Prusiner is an expert in the field of Neurology. He went to medical school at Perelman School of Medicine at the University of Pennsylvania. He received 3 awards: "Elected Member", "Investigator Alumnus" and "Whos Who in Medicine and Healthcare". Dr. Stanley B. Prusiner is a published doctor and has 100 publications published. The lastest was: 'Propagation of prions causing synucleinopathies in cultured cells.'
Publications
- Propagation of prions causing synucleinopathies in cultured cells.
- Structural Studies of Truncated Forms of the Prion Protein PrP.
- Mechanism of Scrapie Prion Precipitation with Phosphotungstate Anions.
- Mouse Models for Studying the Formation and Propagation of Prions.
- Evidence That Bank Vole PrP Is a Universal Acceptor for Prions.
- Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.
- Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.
- Transmission of multiple system atrophy prions to transgenic mice.
- Biology and genetics of prions causing neurodegeneration.
- Drug resistance confounding prion therapeutics.
- A high-throughput screening assay for determining cellular levels of total tau protein.
- Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
- Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds.
- 2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease.
- Convergent replication of mouse synthetic prion strains.
- Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice.
- Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.
- Chimeric elk/mouse prion proteins in transgenic mice.
- Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter.
- Cell biology. A unifying role for prions in neurodegenerative diseases.
- Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.
- Identification of I137M and other mutations that modulate incubation periods for two human prion strains.
- Compartment Modeling for Mammalian Protein Turnover Studies by Stable Isotope Metabolic Labeling.
- Salivary prions in sheep and deer.
- Spontaneous generation of anchorless prions in transgenic mice.
- Prion uptake in the gut: identification of the first uptake and replication sites.
- Protease-resistant prions selectively decrease shadoo protein.
- A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling.
- Conformational Transformation and Selection of Synthetic Prion Strains.
- Conserved properties of human and bovine prion strains on transmission to guinea pigs.
- Erratum to: Generation of antisera to purified prions in lipid rafts.
- A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.
- 2-Aminothiazoles as therapeutic leads for prion diseases.
- Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease.
- Prions.
- Analysis of proteome dynamics in the mouse brain.
- Human prion strain selection in transgenic mice.
- Conformation-dependent high-affinity monoclonal antibodies to prion proteins.
- Colloid formation by drugs in simulated intestinal fluid.
- Chemical induction of misfolded prion protein conformers in cell culture.
- Generation of antisera to purified prions in lipid rafts.
- Discovery of 2-aminothiazoles as potent antiprion compounds.
- Protease-sensitive synthetic prions.
- Design and construction of diverse mammalian prion strains.
- Continuous quinacrine treatment results in the formation of drug-resistant prions.
- Natural and synthetic prion structure from X-ray fiber diffraction.
- Measuring prions by bioluminescence imaging.
- Prion proteins with pathogenic and protective mutations show similar structure and dynamics.
- Is Parkinson's disease a prion disorder?
- Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease.
- Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.
- Cryo-immunogold electron microscopy for prions: toward identification of a conversion site.
- Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.
- A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
- Transmission and detection of prions in feces.
- Small-molecule aggregates inhibit amyloid polymerization.
- Mechanisms of prion protein assembly into amyloid.
- Prion detection by an amyloid seeding assay.
- Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation.
- Electron crystallography of the scrapie prion protein complexed with heavy metals.
- Cell division modulates prion accumulation in cultured cells.
- Polio and Nobel prizes: looking back 50 years.
- Changes in neuropeptide expression in mice infected with prions.
- Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.
- Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmaco...
- Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
- Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models.
- Transmission of elk and deer prions to transgenic mice.
- Human prions and plasma lipoproteins.
- Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
- Prion infection of mouse neurospheres.
- Inactivation of prions by acidic sodium dodecyl sulfate.
- Discovering DNA encodes heredity and prions are infectious proteins.
- Selective precipitation of prions by polyoxometalate complexes.
- Search for a prion-specific nucleic acid.
- Transmission barriers for bovine, ovine, and human prions in transgenic mice.
- Diagnosis of human prion disease.
- Strain-specified characteristics of mouse synthetic prions.
- Notch-1 activation and dendritic atrophy in prion disease.
- Oxidation of methionine residues in the prion protein by hydrogen peroxide.
- Immunoglobulins in urine of hamsters with scrapie.
- The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system.
- Synthetic mammalian prions.
- Detecting mad cow disease.
- Evidence for assembly of prions with left-handed beta-helices into trimers.
- Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
- The peculiar nature of unfolding of the human prion protein.
- Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
- When sporadic disease is not sporadic: the potential for genetic etiology.
- Early evidence that a protease-resistant protein is an active component of the infectious prion.
- Trafficking of prion proteins through a caveolae-mediated endosomal pathway.
- Cytosolic prion protein in neurons.
- Copper coordination in the full-length, recombinant prion protein.
- Differential inhibition of prion propagation by enantiomers of quinacrine.
- Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.
- Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.
- The PrP-like protein Doppel binds copper.
- Perspectives on prion biology, prion disease pathogenesis, and pharmacologic approaches to treatment.
- Prion and doppel proteins bind to granule cells of the cerebellum.
Schools
Perelman School of Medicine University of Pennsylvania
University Calif
Doctors Specialties
- Neurology
Accepted Insurances
Awards
- Elected Member
- Investigator Alumnus
- Whos Who in Medicine and Healthcare
Education
-
UCSF -
Perelman School of Medicine at the University of Pennsylvania
Hospital
-
UCSF Medical Center
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