Professor of Neuropathology
Pathology
Dr. Stephen J. Dearmond, MD
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Dr. Stephen J. Dearmond works in the field of Pathology. He received awards:"Received The Meritorius Service Award from The American Association of Neuroupathologists with an introduction by Stanley Prusiner, M.D", "Received the Graduate Citation Award from Drexel University College of Medicine", "Honored by the AANP Executive Council and Members at Large with an Annual Endowed Lectureship "DeArmond Endowed Lectureship" on Neurodegenerative Diseases", "President of the American Association of Neuropathologists (AANP)", "Landmark Article, American Academy of Neurology, for my widely cited work on prion diseases (Neurology 50:1-2, 1998)", "17th Annual Nobuhisa Baba Memorial Lecturer, Department of Pathology, School of Medicine, Ohio State University: "Prions: Invaders from Innerspace"", "The Robert E. Stowell Lectureship, School of Medicine, University of California at Davis: "In recognition of Dr. DeArmond's contribution to the pioneering research that led to the novel concept of prion-based diseases"", "Acknowledged as major contributor to Nobel Prize in Medicine for Stanley Prusiner", "Alpha Omega Alpha Honor Medical Society: elected to membership in the Medical College of Pennsylvania Chapter", "John D. French Foundation Grant for Alzheimer's Disease", "Academic Senate Grant", "Research Evaluation and Allocation Committee Grant", "Research Associate Award", "Dean's Prize for Outstanding Achievement and Contribution to the Medical College of Pennsylvania" and "Research Training Fellowship". Stephen Dearmond is also published. He has 84 publications published. The lastest publication: "Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.'
Publications
- White matter involvement in sporadic Creutzfeldt-Jakob disease.
- Evidence That Bank Vole PrP Is a Universal Acceptor for Prions.
- AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Trans...
- Transmission of multiple system atrophy prions to transgenic mice.
- Drug resistance confounding prion therapeutics.
- Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
- Convergent replication of mouse synthetic prion strains.
- Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
- Levels of the mahogunin ring finger 1 e3 ubiquitin ligase do not influence prion disease.
- Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.
- Patterns of striatal degeneration in frontotemporal dementia.
- Differential diagnosis of jakob-creutzfeldt disease.
- Chimeric elk/mouse prion proteins in transgenic mice.
- Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter.
- Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.
- Identification of I137M and other mutations that modulate incubation periods for two human prion strains.
- Clinical Overlap between Jakob-Creutzfeldt Disease and Lewy Body Disease.
- A Brain Aggregate Model Gives New Insights Into the Pathobiology and Treatment of Prion Diseases.
- Salivary prions in sheep and deer.
- Spontaneous generation of anchorless prions in transgenic mice.
- Protease-resistant prions selectively decrease shadoo protein.
- Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP Accumulation.
- SAFETY AND TOLERABILITY OF MRI-GUIDED CONVECTION-ENHANCED DELIVERY OF AAV2-hAADC WITH A NOVEL DELIVERY PLATFORM IN NON-HUMAN PRIMATE STRIATUM.
- Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease.
- Conformational Transformation and Selection of Synthetic Prion Strains.
- Clinicopathological correlations in corticobasal degeneration.
- Conserved properties of human and bovine prion strains on transmission to guinea pigs.
- Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia.
- Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease.
- Pathologic evidence that the T188R mutation in PRNP is associated with prion disease.
- Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.
- Human prion strain selection in transgenic mice.
- Conformation-dependent high-affinity monoclonal antibodies to prion proteins.
- Sporadic corticobasal syndrome due to FTLD-TDP.
- Seizures in corticobasal degeneration: a case report.
- Protease-sensitive synthetic prions.
- Design and construction of diverse mammalian prion strains.
- Continuous quinacrine treatment results in the formation of drug-resistant prions.
- Asymptomatic deer excrete infectious prions in faeces.
- Measuring prions by bioluminescence imaging.
- A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.
- Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease.
- The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases.
- Cryo-immunogold electron microscopy for prions: toward identification of a conversion site.
- Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.
- A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformation.
- A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
- Transmission and detection of prions in feces.
- Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution.
- Changes in neuropeptide expression in mice infected with prions.
- Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
- Early frontotemporal dementia targets neurons unique to apes and humans.
- Transmission of elk and deer prions to transgenic mice.
- Human prions and plasma lipoproteins.
- Prion infection of mouse neurospheres.
- Human growth hormone-related iatrogenic Creutzfeldt-Jakob disease with abnormal imaging.
- Inactivation of prions by acidic sodium dodecyl sulfate.
- Prion clearance in bigenic mice.
- Transmission barriers for bovine, ovine, and human prions in transgenic mice.
- Diagnosis of human prion disease.
- Infant botulism, type F, presenting at 54 hours of life.
- Prion-associated dilated cardiomyopathy.
- Strain-specified characteristics of mouse synthetic prions.
- Notch-1 activation and dendritic atrophy in prion disease.
- Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
- Discovering the mechanisms of neurodegeneration in prion diseases.
- The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system.
- Synthetic mammalian prions.
- Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
- Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
- Trafficking of prion proteins through a caveolae-mediated endosomal pathway.
- Cytosolic prion protein in neurons.
- Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
- Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.
- Perspectives on prion biology, prion disease pathogenesis, and pharmacologic approaches to treatment.
- Prion and doppel proteins bind to granule cells of the cerebellum.
- Dominant-negative inhibition of prion replication in transgenic mice.
- A change in the conformation of prions accompanies the emergence of a new prion strain.
- Prions in skeletal muscle.
- Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases.
- Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice.
- Application of quantitative DTI metrics in sporadic CJD.
- Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.
Schools
Medical College of Pennsylvania
Stanford University Med Center
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- Received The Meritorius Service Award from The American Association of Neuroupathologists with an introduction by Stanley Prusiner, M.D
- Received the Graduate Citation Award from Drexel University College of Medicine
- Honored by the AANP Executive Council and Members at Large with an Annual Endowed Lectureship "DeArmond Endowed Lectureship" on Neurodegenerative Diseases
- President of the American Association of Neuropathologists (AANP)
- Landmark Article, American Academy of Neurology, for my widely cited work on prion diseases (Neurology 50:1-2, 1998)
- 17th Annual Nobuhisa Baba Memorial Lecturer, Department of Pathology, School of Medicine, Ohio State University: "Prions: Invaders from Innerspace"
- The Robert E. Stowell Lectureship, School of Medicine, University of California at Davis: "In recognition of Dr. DeArmond's contribution to the pioneering research that led to the novel concept of prion-based diseases"
- Acknowledged as major contributor to Nobel Prize in Medicine for Stanley Prusiner
- Alpha Omega Alpha Honor Medical Society: elected to membership in the Medical College of Pennsylvania Chapter
- John D. French Foundation Grant for Alzheimer's Disease
- Academic Senate Grant
- Research Evaluation and Allocation Committee Grant
- Research Associate Award
- Dean's Prize for Outstanding Achievement and Contribution to the Medical College of Pennsylvania
- Research Training Fellowship
Education
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Stanford University -
Stanford University Medical Center -
University of Michigan
Hospital
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UCSF Medical Center
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