Physician

Pediatrics

Steven Reppert is an expert in the field of Pediatrics. He attended University of Nebraska College of Medicine. He received 2 awards: "Elected Member" and "Whos Who in Medicine and Healthcare". Steven M. Reppert is a published physician. He has 101 publications published. The most current publication "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock."

Publications

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• Sensory basis of lepidopteran migration: focus on the monarch butterfly.
• The genetics of monarch butterfly migration and warning colouration.
• Are monarch butterflies true navigators? The jury is still out.
• Coldness triggers northward flight in remigrant monarch butterflies.
• Anatomical basis of sun compass navigation II: The neuronal composition of the central complex of the monarch butterfly.
• Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases.
• MonarchBase: the monarch butterfly genome database.
• Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies.
• Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain.
• Unraveling navigational strategies in migratory insects.
• The monarch butterfly genome yields insights into long-distance migration.
• Sun compass integration of skylight cues in migratory monarch butterflies.
• Episodes in insect evolution.
• Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies.
• Casein kinase 1 delta regulates the pace of the mammalian circadian clock.
• Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus).
• Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation.
• Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly.
• CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
• Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks.
• The polycomb group protein EZH2 is required for mammalian circadian clock function.
• A clock shock: mouse CLOCK is not required for circadian oscillator function.
• A colorful model of the circadian clock.
• Connecting the navigational clock to sun compass input in monarch butterfly brain.
• A rhythmic Ror.
• Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.
• Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi.
• Illuminating the circadian clock in monarch butterfly migration.
• Targeted disruption of the mouse Mel(1b) melatonin receptor.
• Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity.
• A magnetic compass aids monarch butterfly migration.
• A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer.
• Sudden infant death syndrome continues to baffle researchers.
• Diurnal changes in pineal melatonin content in four rodent species: relationship to photoperiodism.
• Posttranslational mechanisms regulate the mammalian circadian clock.
• Analysis of human Per4.
• Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.
• The circadian clocks of mice and men.
• Keeping time with the human genome.
• Molecular analysis of mammalian circadian rhythms.
• Comparing clockworks: mouse versus fly.
• Cellular and molecular basis of circadian timing in mammals.
• Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.
• A time-less function for mouse timeless.
• Interacting molecular loops in the mammalian circadian clock.
• CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.
• Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms.
• GABA synchronizes clock cells within the suprachiasmatic circadian clock.
• Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding.
• Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches.
• Sex-linked period genes in the silkmoth, Antheraea pernyi: implications for circadian clock regulation and the evolution of sex chromosomes.
• mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
• Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism.
• Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus.
• A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.
• Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).
• Molecular analysis of mammalian timeless.
• A clockwork explosion!
• Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.
• Brain control of embryonic circadian rhythms in the silkmoth Antheraea pernyi.
• Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.
• Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei.
• Melatonin receptors: molecular biology of a new family of G protein-coupled receptors.
• Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock.
• Forward genetic approach strikes gold: cloning of a mammalian clock gene.
• The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei.
• The Mel1a melatonin receptor is coupled to parallel signal transduction pathways.
• Period protein is necessary for circadian control of egg hatching behavior in the silkmoth Antheraea pernyi.
• Circadian clock neurons in the silkmoth Antheraea pernyi: novel mechanisms of Period protein regulation.
• Melatonin receptors step into the light: cloning and classification of subtypes.
• Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters.
• Molecular characterization of prothoracicotropic hormone (PTTH) from the giant silkmoth Antheraea pernyi: developmental appearance of PTTH-expressing cells and relatio...
• Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleus.
• Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor.
• Gap junctions couple astrocytes but not neurons in dissociated cultures of rat suprachiasmatic nucleus.
• Cloning of a melatonin-related receptor from human pituitary.
• Melatonin madness.
• Serotonin receptor gene expression in the rat suprachiasmatic nuclei.
• Functional expression of adenosine A2b receptor in Xenopus oocytes.
• Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution.
• Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin.
• Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.
• Cloning of a structural and functional homolog of the circadian clock gene period from the giant silkmoth Antheraea pernyi.
• Entrainment of the fetal hamster circadian pacemaker by prenatal injections of the dopamine agonist SKF 38393.
• The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.
• Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.
• Interaction between the circadian clocks of mother and fetus.
• Period protein from the giant silkmoth Antheraea pernyi functions as a circadian clock element in Drosophila melanogaster.
• c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation.
• period and timeless tango: a dance of two clock genes.
• Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain.
• Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
• Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a).
• Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores.
• Studies on the daily pattern of pineal melatonin in the Syrian hamster.
• Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siverian (Phodopus sungorus) hamsters and in the rat.
• Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey.
• The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid.
• Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood.
• Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis.

Schools

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• University of Nebraska College of Medicine

Doctors Specialties

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• Pediatrics

Accepted Insurances

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Awards

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• Elected Member
• Whos Who in Medicine and Healthcare

Education

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• Massachusetts General Hospital
• University of Nebraska College of Medicine

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