Associate Professor of Anesthesia

Anesthesiology

Stuart Forman works in the field of Anesthesiology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1 in research and 12 in primary care medicine Stuart Forman is also published. He has 73 publications published. The lastest publication: "Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.'

Publications

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• Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
• Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.
• Research at the Harvard Anesthesia Departments.
• Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.
• Human α1β3γ2L Gamma-Aminobutyric Acid Type A Receptors: High-Level Production and Purification in a Functional State.
• Etomidate Produces Similar Allosteric Modulation in α1β3δ and α1β3γ2L GABAA Receptors.
• Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors.
• A Paradigm Shift from Biophysical to Neurobiological: The Fading Influence of Claude Bernard's Ideas about General Anesthesia.
• The Expanding Genetic Toolkit for Exploring Mechanisms of General Anesthesia.
• Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic.
• Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.
• Carboetomidate Inhibits Alpha4/Beta2 Neuronal Nicotinic Acetylcholine Receptors at Concentrations Affecting Animals.
• Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.
• Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.
• An Allosteric Coagonist Model for Propofol Effects on ?1?2?2L ?-Aminobutyric Acid Type A Receptors.
• p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol.
• Pharmacological Studies of Methoxycarbonyl Etomidate's Carboxylic Acid Metabolite.
• Clinical and molecular pharmacology of etomidate.
• Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
• Molecular approaches to improving general anesthetics.
• p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
• High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.
• Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
• Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.
• Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
• Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
• Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.
• Protein kinase C modulates inactivation of Kv3.3 channels.
• Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.
• General anesthetics and molecular mechanisms of unconsciousness.
• Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.
• Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262.
• Correlating the clinical actions and molecular mechanisms of general anesthetics.
• Of mice and nematodes.
• Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on...
• Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabe...
• Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors.
• Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.
• Mechanisms of actions of inhaled anesthetics.
• 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling lig...
• Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.
• Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.
• Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
• n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate.
• A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant...
• Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus ...
• Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction...
• Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation.
• Ethanol increases agonist affinity for nicotinic receptors from Torpedo.
• Molecular sites of anesthetic action in postsynaptic nicotinic membranes.
• Procaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites.
• High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo.
• Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore.
• General anesthetic and specific effects of ethanol on acetylcholine receptors.
• Direct interactions of anesthetics and nonanesthetics with the nicotinic acetylcholine receptor pore.
• Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action?
• Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.
• The nicotinic acetylcholine receptor in its membrane environment.
• A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step.
• Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.
• Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol.
• Actions of pentobarbital enantiomers on nicotinic cholinergic receptors.
• Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic.
• The gamma subunit determines whether anesthetic-induced leftward shift is altered by a mutation at alpha1S270 in alpha1beta2gamma2L GABA(A) receptors.
• Butanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta2gamma2L gamma-amino butyric acid type A receptors with a mutation at alpha1S270.
• Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.
• The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch.
• Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.
• Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors.
• A discrete site for general anesthetics on a postsynaptic receptor.
• Mechanisms of general anesthesia: from molecules to mind.
• Iatrogenic risk factors for Alzheimer''s disease: surgery and anesthesia.

Schools

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• University Of California San Francisco School Of Medicine

• Contra Costra Reg Med Center

Doctors Specialties

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• Family Medicine
• Anesthesiology

Accepted Insurances

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• WellPoint

Education

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• Massachusetts General Hospital
• Beth Israel Deaconess Medical Center
• Harvard Medical School

Hospital

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• Massachusetts General Hospital

Drug Facts

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NPI NUMBER		1518958628
NPPES Provider LastName		FORMAN
NPPES Provider FirstName		STUART
NPPES Provider ZIPCode		021142621
NPPES Provider State		MA
Specialty Description		Anesthesiology
Total Claim Count		18.0
Distinct Opioid Count		0.0
Opioid Claim Count		0.0
Percent Opioid Claims		0.0

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Medicare Facts

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National Provider Identifier [NPI]	1518958628
Last Name Of The Provider	FORMAN
First Name Of The Provider	STUART
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