Professor, Internal Medicine, University of Kentucky College of Medicine
Cardiology
Dr. Susan S. Smyth, MD
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Susan Smyth is an expert in the field of Cardiology. She went to University of North Carolina at Chapel Hill School of Medicine. University of North Carolina at Chapel Hill School of Medicine is a top medical college. University of North Carolina at Chapel Hill School of Medicine is ranked 22 in research and 2 in primary care medicine She has 2 awards "Elected Member" and "Fellow (FACC)". Doctor Susan S. Smyth, MD is a published physician as well. She has 99 publications published. The latest was: Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q.
Publications
- Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction.
- Consensus Review of the Treatment of Cardiovascular Disease in People With Hemophilia A and B.
- The effect of rosuvastatin on thromboinflammation in the setting of Acute coronary syndrome.
- Lipid phosphate phosphatases: more than one way to put the brakes on LPA signaling?
- Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy.
- Phosphodiesterase Type 4 Blockade Prevents Platelet-Mediated Neutrophil Recruitment at the Site of Vascular Injury.
- Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation Acute coronary syndromes. The TRACER Pharmacodynamic Substudy.
- Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
- Arguing the case for the autotaxin-lysophosphatidic Acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.
- Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.
- Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability.
- Antithrombotic treatment in transcatheter Aortic valve implantation: insights for cerebrovascular and bleeding events.
- Novel mediators and biomarkers of thrombosis.
- QRS duration predicts death and hospitalization among patients with Atrial fibrillation irrespective of heart failure: evidence from the AFFIRM study.
- Antiplatelet therapy in prevention of cardio- and venous thromboembolic events.
- Pathophysiology and Pharmacologic Treatment of Venous Thromboembolism.
- Inflammation and thrombosis in cardiovascular Disease.
- Autotaxinproduction of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.
- Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.
- Fibrinolytic Therapy Versus Primary Percutaneous Coronary Interventions for ST-Segment Elevation Myocardial Infarction in Kentucky: Time to Establish Systems of Care?
- Tissue necrosis factor α and targeting its receptor in ischaemic heart Disease.
- Lysophosphatidic Acid and Cardiovascular Disease: Seeing is believing.
- Bioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial In...
- Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and criti...
- Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia.
- The P2Y(12) Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y(12)/G(i)-Dependent Mechanism.
- Increased mortality among patients taking digoxin-analysis from the AFFIRM study.
- Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury.
- Lipid phosphate phosphatase (LPP3) and vascular development.
- Preventing Platelet Thrombosis with a PAR1 Pepducin.
- Spontaneous coronary thrombosis following thrombolytic therapy for Acute cardiovascular accident and stroke: a case study.
- Invasive Coronary vasoreactivity testing to diagnose microvascular dysfunction in women.
- Autotaxin and its product lysophosphatidic Acid suppress brown adipose differentiation and promote diet-induced obesity in mice.
- Platelet-Mediated Thrombosis and Drug-Eluting Stents.
- Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling.
- Distinct roles for Rap1b in platelet secretion and integrin [alpha]IIb[beta]3 outside-in signaling.
- Connexin 37 counteracts clotting.
- Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.
- Biphasic roles for soluble guanylyl cyclase in platelet activation.
- Plasma levels of sphingosine 1 phosphate are strongly correlated with hematocrit but variably restored by red blood cell transfusions.
- Anti-Platelet Therapy.
- Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways.
- The case against routine aspirin use for primary prevention in low-risk adults.
- Platelets as immune mediators: their role in host defense responses and sepsis.
- Structural basis of substrate discrimination and integrin binding by autotaxin.
- CD40 Is Essential in the Upregulation of TRAF Proteins and NF-KappaB-Dependent Proinflammatory Gene Expression after Arterial Injury.
- Platelets unplugged: an ATVB special series focused on platelet biology.
- Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism.
- A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
- Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phos...
- Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
- Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients.
- Parent-of-origin effects on cardiac response to pressure overload in mice.
- Reduced EGFR causes abnormal valvular differentiation leading to calcific Aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.
- Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.
- Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.
- Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
- Thrombosis and antithrombotic therapy in women.
- Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.
- Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway.
- Platelet activation and its patient-specific consequences.
- Characterization of a model to independently study regression of ventricular hypertrophy.
- Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils.
- Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy.
- Aspirin resistance in patients with stable Coronary artery disease with and without a history of myocardial infarction.
- A case report of simultaneous thrombosis of two Coronary artery stents in association with clopidogrel resistance.
- Src family kinases mediate neutrophil adhesion to adherent platelets.
- Measurement of autotaxin/lysophospholipase D activity.
- CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury.
- Rap1b is required for normal platelet function and hemostasis in mice.
- Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase act...
- In-stent restenosis: more fuel for the fire.
- Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.
- Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.
- Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis.
- Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q.
- Heartburn-dominant, uninvestigated dyspepsia: a comparison of ''PPI-start'' and ''H2-RA-start'' management strategies in primary care--the CADET-HR Study.
- A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations.
- A guide to murine coagulation factor structure, function, assays, and genetic alterations.
- Effects of abciximab on the Acute pathology of blood vessels after arterial stenting in nonhuman primates.
- Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and Edema.
- Platelet functions beyond hemostasis.
- A hamster antibody to the mouse fibrinogen gamma chain inhibits platelet-fibrinogen interactions and FXIIIa-mediated fibrin cross-linking, and facilitates thrombolysis.
- Structure and function of murine alphaIIbbeta3 (GPIIb/IIIa): studies using monoclonal antibodies and beta3-null mice,.
- Preparation of monoclonal antibodies to murine platelet glycoprotein IIb/IIIa (alphaIIbbeta3) and other proteins from hamster-mouse interspecies hybridomas.
- Tweezing apart von Willebrand factor-glycoprotein Ib-IX adhesive signaling.
- The evolution of platelet-directed pharmacotherapy.
- Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent...
- PPARgamma agonists: a new strategy for antithrombotic therapy.
- Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms.
- Cardiovascular Disease in women.
- Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion.
- Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.
- A G(i) -independent mechanism mediating Akt phosphorylation in platelets.
- Dynamic platelet accumulation at the site of the occluded middle cerebral Artery and in downstream microvessels is associated with loss of microvascular integrity afte...
- Regulation of blood and vascular cell function by bioactive lysophospholipids.
- Aspirin dose for the prevention of cardiovascular Disease: a systematic review.
- Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells.
Schools
University of North Carolina At Chapel Hill
Mt Sinai School Of Med
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Automatic Implantable Cardioverter Defibrillator (ICD) Implantation
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
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Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Ectasia
- Aortic Valve Disease
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACC)
Education
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Mount Sinai School of Medicine -
SUNY Stony Brook University Hospital & Medical Center -
University of North Carolina at Chapel Hill School of Medicine
Hospital
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University of Kentucky Albert B. Chandler Hospital
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