Professor, Medicine, Vanderbilt University School of Medicine
Infectious Disease
Dr. Timothy Cover, MD
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Dr. Timothy Cover practices Infectious Disease. He researched medicine at Duke University School of Medicine. Duke University School of Medicine is a top medical university. Duke University School of Medicine is ranked 8/29 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Doctor Timothy Cover, MD is a published doctor. He published 98 publications, including: 'Acid-induced expression of an LPS-associated gene in Helicobacter pylori.'
Publications
- Supporting data for analysis of the Helicobacter pylori exoproteome.
- Regulation of Helicobacter pylori virulence within the context of iron deficiency.
- The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration.
- Analysis of Surface-Exposed Outer Membrane Proteins in Helicobacter pylori.
- Genes Required for Assembly of Pili Associated with the Helicobacter pylori cag Type IV Secretion System.
- Control of gene expression in Helicobacter pylori using the Tet repressor.
- Role of Connexin 43 in Helicobacter pylori VacA-induced cell death.
- Diet, microbial virulence and Helicobacter pylori-induced gastric cancer.
- Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34.
- High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis.
- Comparative Genomic Analysis of East Asian and Non-Asian Helicobacter pylori Strains Identifies Rapidly Evolving Genes.
- Functional Plasticity in the Type IV Secretion System of Helicobacter pylori.
- Structural Analysis of the Oligomeric States of Helicobacter pylori VacA Toxin.
- Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.
- Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans.
- Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori.
- Flagellar Localization of a Helicobacter pylori Autotransporter Protein.
- Nontoxigenic Vibrio cholerae wound infection after exposure to contaminated lake water.
- H. pylori stimulates gastrin release from canine antral cells in primary culture.
- Helicobacter pylori cytotoxin induces vacuolation of primary human mucosal epithelial cells.
- Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology.
- The vacuolating cytotoxin of Helicobacter pylori.
- Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA.
- Helicobacter pylori and gastric acid: biological and therapeutic implications.
- Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production.
- Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin.
- Helicobacter pylori infection in Japanese patients with adenocarcinoma of the stomach.
- Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo.
- Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.
- Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.
- The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism.
- Analysis of genetic diversity in cytotoxin-producing and non-cytotoxin-producing Helicobacter pylori strains.
- Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.
- Detection of Helicobacter pylori gene expression in human gastric mucosa.
- Serologic detection of infection with cagA+ Helicobacter pylori strains.
- Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.
- Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease.
- Correlation between serological and mucosal inflammatory responses to Helicobacter pylori.
- Pseudomonas paucimobilis empyema after cardiac transplantation.
- Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains.
- Helicobacter pylori culture supernatant interferes with epidermal growth factor-activated signal transduction in human gastric KATO III cells.
- Extracellular release of antigenic proteins by Helicobacter pylori.
- An intracellular target for Helicobacter pylori vacuolating toxin.
- Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells.
- Genetic diversity in Helicobacter pylori.
- Commentary: Helicobacter pylori transmission, host factors, and bacterial factors.
- Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly.
- Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.
- Analysis of F1F0-ATPase from Helicobacter pylori.
- High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori.
- Effects of Helicobacter pylori vacuolating cytotoxin on primary cultures of human gastric epithelial cells.
- Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
- Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells.
- A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation.
- In search of the Helicobacter pylori VacA mechanism of action.
- Antigenic diversity among Helicobacter pylori vacuolating toxins.
- Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease.
- Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.
- Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin.
- Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells.
- Intercellular communication in Helicobacter pylori: luxS is essential for the production of an extracellular signaling molecule.
- Cell vacuolation induced by the VacA cytotoxin of Helicobacter pylori is regulated by the Rac1 GTPase.
- Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle.
- A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation.
- Kinetics and mechanisms of extracellular protein release by Helicobacter pylori.
- Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.
- Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori.
- Helicobacter pylori vacuolating cytotoxin (VacA) disorganizes the cytoskeletal architecture of gastric epithelial cells.
- Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles...
- Detection of anti-VacA antibody responses in serum and gastric juice samples using type s1/m1 and s2/m2 Helicobacter pylori VacA antigens.
- Helicobacter pylori factors associated with disease.
- VacA from Helicobacter pylori: a hexameric chloride channel.
- Mutational analysis of the vacA promoter provides insight into gene transcription in Helicobacter pylori.
- The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH.
- Acid-induced expression of an LPS-associated gene in Helicobacter pylori.
- The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
- The pathobiology of Campylobacter infections in humans.
- Vibrio cholerae wound infection acquired in Colorado.
- Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity.
- Evaluation of cytotoxic activity in fecal filtrates from patients with Campylobacter jejuni or Campylobacter coli enteritis.
- Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin.
- Purification and characterization of the vacuolating toxin from Helicobacter pylori.
- Helicobacter pylori and gastroduodenal disease.
- Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori.
- Characteristics of Helicobacter pylori variants selected for urease deficiency.
- Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases.
- Characterization of HeLa cell vacuoles induced by Helicobacter pylori broth culture supernatant.
- Global analysis of Helicobacter pylori gene expression in human gastric mucosa.
- PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA t...
- Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon.
- Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts.
- Multiple oligomeric states of the Helicobacter pylori vacuolating toxin demonstrated by cryo-electron microscopy.
- J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution.
- Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.
- Analysis of cagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity.
- ?-Catenin and p120 mediate PPAR?-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia.
- Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
Schools
Duke University
Ms Hershey Med Center Penn St
University Of Colorado
Vanderbilt University
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- Network S
- Cigna
- Commercial Insurance Company
- Coventry Health Care of Tennessee PPO
- Choice Care PPO
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
Education
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Vanderbilt University -
University of Colorado -
Duke University School of Medicine
Hospital
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Vanderbilt Hospital and Clinics
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