Professor, Medicine, UCSD School of Medicine

Pulmonology

Timothy Bigby is an expert in the field of Pulmonology. He graduated from Baylor College of Medicine. Timothy D. Bigby, MD is a published physician as well. He has 50 publications published. The latest was: TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cell line, THP-1. Timothy D. Bigby accepts Medicare payments and is listed with Medicare.gov.

Publications

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• Innate immunity and Asthma.
• Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster.
• Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo.
• The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide.
• Lipopolysaccharide induces 5-lipoxygenase-activating protein gene expression in THP-1 cells via a NF-kappaB and C/EBP-mediated mechanism.
• Mechanisms of glomerular immune injury: effects of antioxidant treatment.
• 5-lipoxygenase-activating protein gene expression. Key role of CCAAT/enhancer-binding proteins (C/EBP) in constitutive and tumor necrosis factor (TNF) alpha-induced ex...
• Lipopolysaccharide down-regulates leukotriene C4 synthase gene expression in a cell-specific manner in the monocyte-like cell line, THP-1.
• Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1.
• What about the role of the US Food and Drug Administration?
• The yin and the yang of 5-lipoxygenase pathway activation.
• Regulation of leukotriene C4 synthase gene expression by SP1 and SP3 in mononuclear phagocytes.
• Endotracheal Intubation in Mice via Direct Laryngoscopy Using an Otoscope.
• Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
• The leukotriene C(4) synthase gene and Asthma.
• Sp1 and Sp3 function as key regulators of leukotriene C(4) synthase gene expression in the monocyte-like cell line, THP-1.
• Regulation of expression of the 5-lipoxygenase pathway.
• TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cell line, THP-1.
• Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with Asthma receiving zafirlukast.
• Activated lymphocytes increase expression of 5-lipoxygenase and its activating protein in THP-1 cells.
• Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells.
• Leukotriene B4 costimulates 5-lipoxygenase activity in neutrophils via increased 5-lipoxygenase translocation.
• Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35.
• Human monocytes lose 5-lipoxygenase and FLAP as they mature into monocyte-derived macrophages in vitro.
• Lymphocytes stimulate expression of 5-lipoxygenase and its activating protein in monocytes in vitro via granulocyte macrophage colony-stimulating factor and interleuki...
• The intestinal epithelium: a participant in as well as the target of inflammation?
• Involvement of arachidonic acid in the chloride secretory response of intestinal epithelial cells.
• Leukotriene A4 hydrolase in human bronchoalveolar lavage fluid.
• Diagnosis of Pneumocystis carinii Pneumonia. How invasive?
• Inhibition of human peripheral blood lymphocyte function by protoporphyrin and longwave ultraviolet light.
• Captopril inhibits neutrophil synthesis of leukotriene B4 in vitro and in vivo.
• Characterization of human airway epithelial cell leukotriene A4 hydrolase.
• Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels.
• Effects of metalloproteinase inhibitors on leukotriene A4 hydrolase in human airway epithelial cells.
• Effect of macrophage stimulation on parasympathetic airway contraction in dogs.
• The usefulness of induced sputum in the diagnosis of Pneumocystis carinii Pneumonia in patients with the acquired immunodeficiency syndrome.
• Clinical spectrum of Pulmonary mucormycosis.
• Enhanced 5-lipoxygenase activity in Lung macrophages compared to monocytes from normal subjects.
• Leukotriene A4 hydrolase activity of human airway epithelial cells.
• Transcellular lipoxygenase metabolism between monocytes and platelets.
• Bleomycin-induced Lung injury in the rabbit. Analysis and correlation of bronchoalveolar lavage, morphometrics, and fibroblast stimulating activity.
• Effect of interferon-gamma on the 5-lipoxygenase pathway of rat Lung macrophages.
• Transcellular metabolism of leukotrienes in the Lung.
• LTA4 hydrolase of human airway epithelial cells. Comparison with neutrophils.
• Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis.
• The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.
• Cobinamide is superior to other treatments in a mouse model of cyanide poisoning.
• Intranasal ketorolac challenge for the diagnosis of aspirin-exacerbated respiratory Disease.
• A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.

Schools

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• Baylor University

Procedures Preformed

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• Thoracentesis

Conditions Treated

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• Acidosis
• Asthma
• Atelectasis
• Bronchiectasis
• View All

Doctors Specialties

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• Critical Care Medicine
• Pulmonology

Accepted Insurances

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Education

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• University of Colorado
• Baylor College of Medicine

Helpful Reviews

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Give Anonymous Review

Medicare Facts

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National Provider Identifier [NPI]	1902820327
Last Name Of The Provider	BIGBY
First Name Of The Provider	TIMOTHY
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