Professor of Pathology, USC School of Medicine
Pathology
Dr. Timothy J. Triche, MD
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Timothy Triche works in the field of Pathology. He studied medicine at Tulane University School of Medicine. He received 4 awards: "America's Top Doctors", "Top Doctors:LA Area", "America's Top Doctors for Cancer" and "Top Doctors:Southern California". Timothy Triche is a published physician as well. He has 61 publications published. The latest was: Synergisitic and Antagonistic AML Cell Type-specific Responses to 5-Aza-2-deoxycitidine and 1-h-D-Arabinofuranoside.
Publications
- Activity of MM-398, Nanoliposomal Irinotecan (nal-IRI), in Ewing's Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN11 Expression.
- Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer.
- The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation.
- DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development.
- Reprogramming of the intestinal epigenome by surgical tissue transposition.
- Validation of a Genomic Classifier that Predicts Metastasis Following Radical Prostatectomy in an At Risk Patient Population.
- A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy.
- T lymphocyte abnormalities in juvenile systemic sclerosis patients.
- The Cancer Genome Atlas Pan-Cancer analysis project.
- The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.
- A novel algorithm for simplification of complex gene classifiers in cancer.
- PAX-FOXO1 Fusion Status Drives Unfavorable Outcome for Children With Rhabdomyosarcoma: A Children's Oncology Group Report.
- Low-level processing of Illumina Infinium DNA Methylation BeadArrays.
- FOXM1 Is an Oncogenic Mediator in Ewing Sarcoma.
- Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor.
- Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study.
- Correction: The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA.
- Influence of RNA Labeling on Expression Profiling of MicroRNAs.
- Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group.
- Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group.
- Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.
- Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature.
- Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
- Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells.
- Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group.
- Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation.
- Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group.
- Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyo...
- Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.
- Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group.
- Extraosseous Ewing's sarcoma: 25 years later.
- BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.
- Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations.
- Molecular characterization of the pediatric preclinical testing panel.
- Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation.
- Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic diffe...
- Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.
- E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase.
- Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease.
- Experimental comparison and evaluation of the Affymetrix exon and U133Plus2 GeneChip arrays.
- Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation o...
- Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas.
- The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.
- Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.
- The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor.
- Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma.
- A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 2. In vitro and in vivo uptake results.
- EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
- Affymetrix oligonucleotide analysis of gene expression in the injured heart.
- Lack of interferon response in animals to naked siRNAs.
- Retinoid-modulated MAT1 ubiquitination and CAK activity.
- Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas.
- MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth.
- Growth inhibition of breast epithelial cells by celecoxib is associated with upregulation of insulin-like growth factor binding protein-3 expression.
- Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic aci...
- Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions.
- cDNA microarray analysis of global gene expression in sarcomas.
- PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
- Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line.
- Synergisitic and Antagonistic AML Cell Type-specific Responses to 5-Aza-2-deoxycitidine and 1-h-D-Arabinofuranoside.
Schools
Tulane University of Louisiana
Barnes Jewish Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:LA Area
- America's Top Doctors for Cancer
- Top Doctors:Southern California
Education
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Washington University -
Tulane University School of Medicine
Hospital
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Children's Hospital Los Angeles
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