Professor, Medicine, University of Minnesota Medical School

Internal Medicine

Timothy W. Schacker, MD works in the field of Internal Medicine. He researched medicine at University of Minnesota Medical School. University of Minnesota Medical School is ranked 40/10 in Research/PrimaryCare. He has 2 awards "CMS Meaningful Use Stage 1 Certification" and "Super Doctor". Doctor Timothy W. Schacker, MD is also a published doctor. He has 90 paper published. The most recent paper is: Potential for the transmission of HIV-1 despite highly active antiretroviral therapy.

Publications

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• Persistent HIV-1 replication maintains the tissue reservoir during therapy.
• Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
• Inguinal lymph node and anorectal mucosal biopsies for human immunodeficiency virus research protocols in an emerging nation: patient outcomes and lessons learned.
• Defining Success With Antiretroviral Therapy.
• Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues.
• Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
• The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized trial.
• Interferon-? Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers.
• Overcoming pharmacologic sanctuaries.
• Impaired T cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
• Critical role for CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution.
• Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.
• The Immunosuppressive Role of IL-32 in Lymphatic Tissue during HIV-1 Infection.
• Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections.
• A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection.
• Reduction of immune activation with chloroquine therapy during chronic HIV infection.
• Host genes associated with HIV-1 replication in lymphatic tissue.
• HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.
• Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection.
• Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire.
• A step ahead on the HIV collaboratory.
• Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretro...
• Collagen deposition limits immune reconstitution in the gut.
• Accuracy of herpes simplex virus detection in liquid-based (SurePath) Papanicolaou tests: a comparison with polymerase chain reaction.
• Inguinal lymph node biopsy in patients infected with the human immunodeficiency virus is safe.
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
• Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.
• Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects.
• Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.
• Ex vivo modeling of oral HIV transmission in human palatine tonsil.
• CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract.
• Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy.
• Imiquimod 5-percent cream does not alter the natural history of recurrent herpes genitalis: a phase II, randomized, double-blind, placebo-controlled study.
• Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis.
• Points of recombination in Epstein-Barr virus (EBV) strain P3HR-1-derived heterogeneous DNA as indexes to EBV DNA recombinogenic events in vivo.
• High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage.
• Bordetella bronchiseptica pneumonia and bacteremia following bone marrow transplantation.
• Pharmacological basis for concentration-controlled therapy with zidovudine, lamivudine, and indinavir.
• Valaciclovir versus aciclovir for herpes simplex virus infection in HIV-infected individuals: two randomized trials.
• Biological and virologic characteristics of primary HIV infection.
• Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
• Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection.
• Reversibility of the pathological changes in the follicular dendritic cell network with treatment of HIV-1 infection.
• Potential for the transmission of HIV-1 despite highly active antiretroviral therapy.
• A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patie...
• Herpes simplex virus seropositivity and reactivation at delivery among pregnant women infected with human immunodeficiency virus-1.
• The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue.
• Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.
• The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.
• Lack of detection of HSV DNA in PBMCs and lymph nodes of HIV-infected persons.
• Clinical and epidemiologic features of primary HIV infection.
• Topical treatment of infection with acyclovir-resistant mucocutaneous herpes simplex virus with the ribonucleotide reductase inhibitor 348U87 in combination with acycl...
• The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia.
• Potential for combined therapy with 348U87, a ribonucleotide reductase inhibitor, and acyclovir as treatment for acyclovir-resistant herpes simplex virus infection.
• Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected men: correlation of high levels with high CD4 cell counts.
• Phase I study of high-dose, intravenous rsCD4 in subjects with advanced HIV-1 infection.
• Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men.
• Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men.
• Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: implications for antiviral therapy.
• Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons. A double-blind, placebo-controlled trial.
• Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection.
• HSV-2 and HIV: consequences of an endemic opportunistic infection.
• Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS.
• Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection.
• Mucosal shedding of human herpesvirus 8 in men.
• Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral...
• Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection.
• The role of HSV in the transmission and progression of HIV.
• Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression.
• Imiquimod and genital herpes.
• Clinician and patient recognition of anogenital herpes disease in HIV positive men who have sex with men.
• The role of secondary lymphatic tissue in immune deficiency of HIV infection.
• ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand.
• Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection.
• Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.
• New tools to track HIV.
• Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
• PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
• Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infect...
• An update on short-course episodic and prevention therapies for herpes genitalis.
• HIV binding, penetration, and primary infection in human cervicovaginal tissue.
• A model system of oral HIV exposure, using human palatine tonsil, reveals extensive binding of HIV infectivity, with limited progression to primary infection.
• Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy.
• Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjects.
• Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count.
• Measurement of naive CD4 cells reliably predicts potential for immune reconstitution in HIV.
• The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche.
• Concentration-controlled compared with conventional antiretroviral therapy for HIV infection.
• Primary HIV infection. Early diagnosis and treatment are critical to outcome.

Schools

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• University of Mn Med Sch

• Oregon Health and Science University

• University of Washington

Doctors Specialties

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• Infectious Disease Medicine
• Internal Medicine

Accepted Insurances

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Awards

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• CMS Meaningful Use Stage 1 Certification
• Super Doctor

Education

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• University of Washington
• Oregon Health & Science University
• University of Minnesota Medical School

Hospital

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• University of Minnesota Medical Center, Fairview

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